Protein Alignment SLC22A16 and CG10486

DIOPT Version :9

• Sequence 1: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 147/613 - (23%)
• Similarity: 269/613 - (43%)
• Gaps: 102/613 - (16%)

Human     6 FEGIYDHVGHFGRFQ-RVLYFICAFQNISCGIHYLASVFMGVT-PHHVCRPPGNVSQVVFHNHSN 68
            |:.:...:|.||||| |:..|:..|..|:..: ||..:||.:| |.:.|..|..:       |:.
  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFV-YLGQIFMCLTPPKYYCYVPELL-------HTP 152

Human    69 WSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQ 133
            ..|....::.......|...::.|....::     :..||.|:  |..| |....||..||:::|
  Fly   153 VELRKELSIPKEKDGSYSRCRMYNTNYTKI-----HFAENPSA--YINT-SLPTIPCKKGYVFEQ 209

Human   134 --NTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFG 196
              ..::| |..::..:||....|...|.:|..|.:||.:.:|:|:|..||...|.::.....:..
  Fly   210 EGRAFES-ATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGS 273

Human   197 IAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW-ASVHLHSFFAVGTLLVALT 260
            :|.:.:.|::||..:||.:.........:.::.|:|::|.|.||. |::.|..|::..|:::...
  Fly   274 LATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWI 338

Human   261 GYLVRTWWLYQMILSTVTVPFILCCW---VLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKL 322
            ......|   :...|..::|.:|..:   :|||:..||:|.|..::|.:|:..:.:.|:....|
  Fly   339 ALSAGNW---RRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSK- 399

Human   323 SELLSLDLQGPVSNSPTEVQKHNLS-------YLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNS 380
             |:|.|     ...|.|:..|..|.       .:|....:.:..:.:.|||.:.|| .|...:.:
  Fly   400 -EILDL-----FEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISL-VYDGHVRA 457

Human   381 VNLGGNEYLNLFLLGVV----EIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYI 441
            .::..:|  |:||...:    |:|....|.:.:|:.|||..   |.|.::|: ||..       :
  Fly   458 ASVLDSE--NIFLFFTIACATELPGNILVILTLDRAGRRWC---SFFYTSLS-GVFS-------L 509

Human   442 LGV---------VTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVD 497
            ||.         ::|:.|:|.....:.:...:.||:.||:||:..|.....:..:|.:::|..|.
  Fly   510 LGASFQNRANMRMSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVY 574

Human   498 LSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATT--------------------------- 535
            ||...:....:.:|.:.:..|:|.|.|||||...|..|
  Fly   575 LSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSH 639

Human   536 ----WEEAAKLE--SENESKSSKLLLTT 557
                |.:.:.|.  |::|.:|||:...|
  Fly   640 PRHNWHQGSSLRTLSKDEFRSSKMYRKT 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	137/548 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		6/17 (35%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	137/548 (25%)
		MFS	231..602	CDD:119392	94/394 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850