DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG8654

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	146/534 - (27%)
Similarity:	240/534 - (44%)	Gaps:	71/534 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     9 IYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLED 73
            |...:|.|.|:|...:||........|.|.|..:|:.......|
  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSC--------------------- 67

Human    74 TGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYI---YDQNT 135
                                           |.||.:.            ||.|...   :|.:.
  Fly    68 -------------------------------KTENVTD------------PCSDECSETEFDTSV 89

Human   136 WKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAA 200
            ::||.:|:|||.|:.|.||.|.|.:.|.|:|.||:.||.|:||.|||...........:.|:...
  Fly    90 FQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVC 154

Human   201 FAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVR 265
            .:..|:.:...||.:|:..:|.:...||.:||.:|.|.|...::.....|.:|...:||..|.:|
  Fly   155 VSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIR 219

Human   266 TWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDL 330
            .|..:|..::..::.|::..|::||:|.||.:.|:.:::.||::.:||.|:|.:..:...:....
  Fly   220 EWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAY 284

Human   331 QGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLG 395
            ....:..|  |:|..:..||....:..:|:.:...|....:.:|..:.....||||.:::..:..
  Fly   285 GALAARQP--VKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAA 347

Human   396 VVEIPAYTFVCIAMDK-VGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFG 459
            .|.||. |.:|..|.| :||:..|..|..||||...::..:..:...:.|..|.:|.|.....|.
  Fly   348 GVGIPG-TCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFP 411

Human   460 LIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKL 524
            .:|||..||:||:|||..||..|||.|:.||:||..|||::..:::..|..|..::|:.:.|:.|
  Fly   412 NVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFL 476

Human   525 PETLGKRLATTWEE 538
            |||.|..|..|.|:
  Fly   477 PETRGTPLPETLED 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	143/524 (27%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG8654	NP_001246441.1	SP	85..487	CDD:273317	126/404 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	119/392 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950