Protein Alignment SLC22A16 and CG4630

DIOPT Version :9

• Sequence 1: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 591
• Identity: 176/591 - (29%)
• Similarity: 282/591 - (47%)
• Gaps: 79/591 - (13%)

Human     6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNW- 69
            |:.|...:|.||||||..|.:.....:....:.|:.||...:|.:.|..|.....|.....:||
  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWV 79

Human    70 SLEDTGALLSSGQKDYVTVQ--LQNGE----------IWELSRCSRNKRENTSSLGYEYTGSKKE 122
            |:...|:....|.....|.:  :.||:          .|.|.:|.   .||.::          |
  Fly    80 SIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCF---AENFTT----------E 131

Human   123 FPCVDGYIYDQNTWKSTAVTQWNLVC-DRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLW 186
            ....:.::|..:  :.|.|.||.|.| :..|....:..:...|:::|:...||.:||.||:.:..
  Fly   132 TERCNQFVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFL 194

Human   187 ATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFA 251
            .....|.|.|:|.|.:.||.:|:......|:..||...:.|:..:|.:|.:.|..:|:.|:.|:|
  Fly   195 FCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYA 259

Human   252 VGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC---WVLPETPFWLLSEGRYEEAQKIVDIMAK 313
            ||..|:.|:.:| ..|...|:.||   ||.::|.   |::||:..|||:..|.|:|..|:...||
  Fly   260 VGEALLGLSVFL-PDWRQLQLALS---VPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAK 320

Human   314 WNR-------ASSCKLSEL-----LSLDLQGPVSNSPTEVQKHNLSYLFY-----NWSITKRTLT 361
            .||       .:|.|..||     ...|::|.:     .|:|.:..:|..     :..:..|...
  Fly   321 VNRRDISVELMASFKQQELDAETGQEDDVEGGL-----HVKKDDKIWLAVKEVARSHILMGRYAI 380

Human   362 VWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSA 426
            :.|||...::.:|..|||:.:|.||:|||..|:.:||||.|:...:.:.:.|||..|:.||...:
  Fly   381 LLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCS 445

Human   427 LAC---GVVMVIPQKHYI-----------------LGVVTAMVGKFAIGAAFGLIYLYTAELYPT 471
            :.|   |.| .:.|..:|                 |.|...:|||..|.::|.:||.:|||:.||
  Fly   446 ITCVASGFV-TLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPT 509

Human   472 IVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTW 536
            ::||..||..|...|..::||||...|:|.:..:|.|..||::|::|:|:|.||||..::|..|.
  Fly   510 VIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTV 574

Human   537 EEAAKL 542
            |||..|
  Fly   575 EEAIAL 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	169/574 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		176/591 (30%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	169/574 (29%)
		MFS	158..533	CDD:119392	117/384 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930