DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A16 and CG3168

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	104/466 - (22%)
Similarity:	177/466 - (37%)	Gaps:	95/466 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   148 CD-------RKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDY 205
            ||       :.||..:|    ..|:::|:..:|..:|..||:.||...|.......:|::|:..|
  Fly   180 CDLDLNTETKGWLNSII----FIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTY 240

Human   206 YTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLV------ 264
            ..||..||.......|...|.:.|..||.....|......:.:|:..|.|.||...:|:
  Fly   241 SFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIG 305

Human   265 --------RTWWLYQMI--LSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASS 319
                    .:|.::.::  |.:..|.|:|  :.|||:|.:||:.|:.:.|..|...:...|  :.
  Fly   306 FTTPYFTYNSWRIFLLVCSLPSFLVGFLL--FYLPESPKFLLTRGKKDRALAIFRGIFVTN--TK 366

Human   320 CKLSELLSLDLQ---------GPVSNSPTEVQKHNL--SYLFYNWSITKRTLTVWLIWFTGSLGF 373
            .:..|.:..||:         |.|.|..:.:....:  |...:...|.:.|:....|.||..:|:
  Fly   367 RRPDEYMVYDLEVDEKLLESNGNVKNKYSRMISGMVDHSRALFKSPILRFTIVSITINFTFHIGY 431

Human   374 Y------------------SFSLNS----------VNLGGNEYLN----------LFLLGVVE-- 398
            |                  :|...|          |||...:..|          :|:..::.
  Fly   432 YGLLMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKEQSNNGTCSSDIPQSVFMESLISLA 496

Human   399 --IPAYTFVCIAMDKVGRRTVLAYSL----FCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAA 457
              :||.....:.||.:||:..|....    .||||...|      :..:..:|.:.:...||.||
  Fly   497 SALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFV------RSSVQNLVVSAIFSGAISAA 555

Human   458 FGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLT 521
            ...:.....|::||.:|:..|....:..||..|:....: .|...:...|...|..:.:..|::.
  Fly   556 NAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVSGLLIGGGLMC 620

Human   522 LKLPETLGKRL 532
            |.||.|..|.|
  Fly   621 LLLPNTTRKEL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	104/466 (22%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	94/431 (22%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	99/456 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940