Protein Alignment PPFIA3 and ppfia3

DIOPT Version :10

• Sequence 1: NP_003651.1
• Gene: PPFIA3 / 8541
• HGNCID: 9247
• Length: 1194
• Species: Homo sapiens
• Sequence 2: XP_003198161.2
• Gene: ppfia3 / 567230
• ZFINID: ZDB-GENE-100311-3
• Length: 1226
• Species: Danio rerio
• Alignment Length: 1253
• Identity: 930/1253 - (74%)
• Similarity: 1024/1253 - (81%)
• Gaps: 86/1253 - (6%)

Human     1 MMCEVMPTISEDGRRGSALGP-----------------------------DEAG--GELERLMVT 34
            ||||||||||||||.|:..||                             ||.|  |.||.|||.
Zfish     1 MMCEVMPTISEDGRGGAGGGPSSPAGGGGGMGGGAGGMGGGYGGREARGGDEGGSTGNLESLMVN 65

Human    35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLER 99
            ||||||||||:|||.|:.|.|||||||||||||||||||||||||||||.||||||:||||||||
Zfish    66 MLTERERLLESLRETQESLGTAQLRLRELGHEKDSLQRQLSIALPQEFAVLTKELNVCREQLLER 130

Human   100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHK 164
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
Zfish   131 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHK 195

Human   165 ALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGG 229
            |||||||||||:|||||||||||||.|..|.|:||:|:.||..||:. ||    :.|.||.....
Zfish   196 ALDEKVRERLRVALERVAVLEEELESSTNEVLSLRDQIKRRERGLDN-GK----ERLPNGPSSIL 255

Human   230 DSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEA 294
            |......:.|..:||||||:.||:||||::|||:.::||:|.||.|||.|:||||.|||||:|||
Zfish   256 DDGEIDRQREGEIERQRAELSQLKERLALMCRQVGEIEEQLTTARRELAKSEEANQKLQRDVKEA 320

Human   295 LAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQ 359
            |.|||||||||||||:||||||||||||||..||||||||||||||||||||:|||.|.||||||
Zfish   321 LCQREDMEERITTLERRYLSAQREATSLHDIKDKLENELASKESLYRQSEEKNRQLQERLDDAKQ 385

Human   360 KLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMND 424
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Zfish   386 KLQQTLQRAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQRERMND 450

Human   425 DHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMER 489
            :||||||:|||||||||||||||||||||.||||||:||||:|||||:||:||.||:||:||:||
Zfish   451 EHNKRLSDTVDKLLSESNERLQLHLKERMAALEEKNALSEELANMKKIQDDLLANKDQLIAELER 515

Human   490 MQMEIDQLRGRPPSSYSRSLPGSALELRYSQ-APTLPSGA--HLDPY----VAGSGRAGKRGRWS 547
            :|:|:|||||||.|||||||||||||||||| ..:||:|:  ||:.|    ..|..|...|||||
Zfish   516 LQLELDQLRGRPGSSYSRSLPGSALELRYSQGGGSLPAGSTTHLEHYGNTGTGGVVRRTHRGRWS 580

Human   548 GVKEEPSK--DWERSAPAGSIPPPFPGELD---GSDEEEAEGMFGAELLSPSGQADVQTLAIMLQ 607
            |.:|:.||  |||..|..||   .|.|.::   ..|||:.|.:||:||||||||.||||||||||
Zfish   581 GAREDASKYGDWESGALLGS---GFEGGVEDRCSDDEEDRETLFGSELLSPSGQTDVQTLAIMLQ 642

Human   608 EQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLD-------SLGRYRSSCS-LPPSLTTSTL 664
            ||||||||||||||||||:||.||||:||||||..||       ||||..:... :|||||:|||
Zfish   643 EQLEAINKEIKLIQEEKESTELRAEEIESRVSSVALDGPPIPPTSLGRDSTGRGFIPPSLTSSTL 707

Human   665 ASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGAPRGEGPAIPGDTPPPTPRSARLERMTQ 729
            ||||||||||||||| |.||||| ||:.|:  ||:     ....|:...|||||||:.||:|||.
Zfish   708 ASPSPPSSGHSTPRL-PHSPARE-TDRQNN--KED-----DRSLALLDSTPPPTPRALRLDRMTH 763

Human   730 AL--ALQAGSLE------DGGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDS 786
            ..  ||...|.|      ||.   .|..:.||||||.||||||||||||||||:|.|||.|||:|
Zfish   764 THPGALLDDSREFRSLSADGS---SSNSSQDSLHKASKKKSIKSSIGRLFGKKDKVRMGQPGRES 825

Human   787 SSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWV 851
            :|||.||||:....|||||.|:.||.|||||:|:||||||||||||||||:||||||||||||||
Zfish   826 TSLASTPSDDLGTVDPLGLTKMAGPVDKDRRSKKKHELLEEACRQGLPFASWDGPTVVSWLELWV 890

Human   852 GMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTS 916
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|:|
Zfish   891 GMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASTRSS 955

Human   917 TGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDA 981
            |.||||||.|||||||.||||.|||||:|||||||||||||||||||||||||||||||||||||
Zfish   956 TSNVWMTHAEMESLTAATKPELKEISWDQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDA 1020

Human   982 RMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERV 1046
            ||||||.||||||||||||||||||:|||||||||||||||:|||||:|||.|.:||||||||||
Zfish  1021 RMLDHLTKKELRGQLKMVDSFHRVSMHYGIMCLKRLNYDRKELERRRDESQHQNKDVMVWSNERV 1085

Human  1047 MGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLG 1111
            |.||..:||||:|.|||||||||||||||:||||:|||||||||.||.|||||||||:::|||:|
Zfish  1086 MCWVQSIGLKEYADNLTESGVHGALLALDDTFDYTDLALLLQIPNQNTQARQLLEKEYNSLISMG 1150

Human  1112 TDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEG 1176
            |:||.|||..|:|:||||||||||||||||||.||:|.||.|||   |.|:.:|.:.|||:
Zfish  1151 TERRPDEDGTKTFTRSPSWRKMFREKDLRGVTSDSSETLPANFR---ASAISTPSVTLRKV---- 1208

Human  1177 QTSGSSRADGVSVRTYSC 1194
            |:..|.||:..|||||||
Zfish  1209 QSDASPRAESGSVRTYSC 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPFIA3	NP_003651.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		17/50 (34%)
		Smc	39..>635	CDD:440809	470/607 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..233		10/30 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..583		27/68 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..819		124/210 (59%)
		PHA03307	630..>836	CDD:223039	135/221 (61%)
		SAM_liprin-alpha1,2,3,4_repeat1	835..905	CDD:188961	68/69 (99%)
		SAM_liprin-alpha1,2,3,4_repeat2	952..1017	CDD:188964	62/64 (97%)
		SAM_liprin-alpha1,2,3,4_repeat3	1037..1108	CDD:188967	57/70 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1157..1194		15/36 (42%)
ppfia3	XP_003198161.2	Smc	77..>670	CDD:440809	464/600 (77%)
		SAM_liprin-alpha1,2,3,4_repeat1	874..944	CDD:188961	68/69 (99%)
		SAM_liprin-alpha1,2,3,4_repeat2	991..1056	CDD:188964	62/64 (97%)
		SAM_liprin-alpha1,2,3,4_repeat3	1076..1147	CDD:188967	57/70 (81%)