Protein Alignment PPFIA3 and Liprin-alpha

DIOPT Version :10

• Sequence 1: NP_003651.1
• Gene: PPFIA3 / 8541
• HGNCID: 9247
• Length: 1194
• Species: Homo sapiens
• Sequence 2: NP_001260155.1
• Gene: Liprin-alpha / 249072
• FlyBaseID: FBgn0046704
• Length: 1214
• Species: Drosophila melanogaster
• Alignment Length: 1276
• Identity: 609/1276 - (47%)
• Similarity: 789/1276 - (61%)
• Gaps: 220/1276 - (17%)

Human     1 MMCEVMPTISED--GRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLREL 63
            |||:||||||||  .:|.|....::|  ..|:|||:||.||::|:::|||||:.|...:.:||::
  Fly     4 MMCDVMPTISEDSISQRSSQFSGEDA--NFEQLMVSMLDERDKLMDSLREAQERLNETENKLRDV 66

Human    64 GHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHE 128
            ..|:||||||::..||||||.|||||...||.||||:|||.||||||||||||||||||||||||
  Fly    67 EKERDSLQRQINANLPQEFATLTKELTQARETLLERDEEIGELKAERNNTRLLLEHLECLVSRHE 131

Human   129 RSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ 193
            ||||||||||||.:..|||||||||||||||||||||||||||||||:::|:..::||||.
  Fly   132 RSLRMTVVKRQAAAQSGVSSEVEVLKALKSLFEHHKALDEKVRERLRLSIEKNNMMEEELS---- 192

Human   194 ETLNLREQLSRRRSGLEEPGKD-----GDGQTLA------NGL-----------GPGGDSNR--- 233
               :.:|:|::.::|:...|..     |...|.|      |||           |..|::|.
  Fly   193 ---SAKEELAQYKAGVVPAGVGSGSGAGSAATTAGGGGAENGLKEKMAGVGGSGGVNGEANELND 254

Human   234 ---RTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEAL 295
               :|.||:..:|:|.:|:.|.:.|::.|..::|:|||.:....:|..||::..:||||||:|.:
  Fly   255 YAAKTHELQTIIEKQTSELSQWQRRVSDLNNKISELEENMSRVQKEHCKAQDQCAKLQRDLRENV 319

Human   296 AQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQK 360
            ||:||.||||||||||||:||||:|||||.|:|||.||..||:..:..|||...:.|.|:.::||
  Fly   320 AQKEDQEERITTLEKRYLNAQRESTSLHDLNEKLEQELRHKEAQLKLHEEKIGAIEEKLELSEQK 384

Human   361 LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDD 425
            |   .|.|:..|::|.||..|:.||.||:||||:.|:|:|.||..|:||..|:.|..||.|||::
  Fly   385 L---AQHAKLQPDMEEQLKARMEALTKAQERHGSAEDRIRGLETNLDEKTNEVVRLNQRLKMNEE 446

Human   426 HNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERM 490
            ||.|||.||||||||||||||:||||||.||:|||:|::|:...:|:.:||...|.:::.|:.:.
  Fly   447 HNLRLSSTVDKLLSESNERLQVHLKERMHALDEKNALTQELEKARKVAEELHHEKSEIMKELSKT 511

Human   491 QMEIDQLRG-----------RPPSSYSRSL-PGSALELRYSQAPTLPSGA------HLDPYVAGS 537
            ::||:..:.           :...:.:||| |.|.::         ||||      |.. :...|
  Fly   512 RLEIENFKRQLLQQEIAYNIQQTEALTRSLSPSSVVD---------PSGAFSRSNSHAS-FETHS 566

Human   538 GRAGKRGRWSG----VKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGA--ELLSPSGQ 596
            .|...:.|.|.    |:....::||:...|.............:|.::::.::.|  :::||||.
  Fly   567 LRRQSKQRLSEENALVRSMAEQEWEKLQQAAHAQQQAYELASAADCDDSDVLYAAATDMMSPSGH 631

Human   597 ADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSS-SGLDSLGRYRSSCSLPPSLT 660
            .|.||||:||||||:|||.||:||||||::||.|||||||||.| ..::.|.|.||
  Fly   632 TDAQTLAMMLQEQLDAINNEIRLIQEEKQSTEARAEELESRVGSLEHVNLLARGRS--------- 687

Human   661 TSTLASPSPPSSGHSTPRLAPPSPAREGTDKAN--HVPKEEAGAPRGE---GPAIPGDT------ 714
               :...|||.||.|||.    ||.|:...|.:  ::|...:.|.|.|   |.:..||:
  Fly   688 ---MDRQSPPMSGRSTPN----SPQRDFMQKYHTLNLPVLSSDASREELHGGMSTTGDSSSGGAA 745

Human   715 PPPTPRSARLERMTQALA-----LQAGSL-----------EDGG------------PPRGSEGTP 751
            .|.|.||.||||:.||||     |:..|:           ..||            |.....|:.
  Fly   746 SPLTARSMRLERVAQALAHSQEELRRRSIGLNPNASVAPNHTGGHMPLSSHSYGLSPLSSRYGSQ 810

Human   752 DSLH-----------KAP--------------KKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLAG 791
            :||.           :.|              |||.||||:||.|.||||.:    |...:...|
  Fly   811 ESLRHYNTMGSMSMLQTPTSGVSREAAAAAVQKKKGIKSSLGRFFSKKEKVK----GVKDTLPDG 871

Human   792 TPSDETLATDPLGLAK---------LTG---------PGDKDR-----RNKRKH----ELLEEAC 829
            :||..::....:||::         :||         .|.|..     |.|::|    :||.||.
  Fly   872 SPSMMSIGNLSIGLSEVDSNYDAMSMTGGMMPRIASSQGSKISSVDYGRQKKEHDYRNDLLGEAM 936

Human   830 RQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKL 894
            :.|.|||.|:|||:|:||||||||||||||||||||||||||:.|||||||||||||||||||||
  Fly   937 KAGTPFALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKL 1001

Human   895 RLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGN 959
            ||||||||||||||||.:|||:                              ||:|||||||:||
  Fly  1002 RLAIQEMVSLTSPSAPQTSRTT------------------------------LAFGDMNHEWIGN 1036

Human   960 DWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDL 1024
            .|||.|||||||:.|||.||||||||||.||:|||||||||||||.||.|||..||||||||.:|
  Fly  1037 YWLPGLGLPQYRTTFMECLVDARMLDHLTKKDLRGQLKMVDSFHRTSLQYGISMLKRLNYDRTEL 1101

Human  1025 ERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQI 1089
            |.||:.|:..:.||:|||||||:.||..:||||:|.||.||||||.|:||||.||.:.:.|.|||
  Fly  1102 EHRRKMSENGLCDVLVWSNERVIRWVGSIGLKEYANNLLESGVHGGLMALDEGFDANAMGLALQI 1166

Human  1090 PTQNAQARQLLEKEFSNLISLGTDRRLDED--SAKSFSRSP 1128
            |||||||||:|:.||:||:.:.||||.:.:  ||. .|.||
  Fly  1167 PTQNAQARQILDTEFNNLLQIATDRRPENEQRSASXCSYSP 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPFIA3	NP_003651.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		13/23 (57%)
		Smc	39..>635	CDD:440809	307/647 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..233		11/52 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..583		14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..819		82/282 (29%)
		PHA03307	630..>836	CDD:223039	87/297 (29%)
		SAM_liprin-alpha1,2,3,4_repeat1	835..905	CDD:188961	63/69 (91%)
		SAM_liprin-alpha1,2,3,4_repeat2	952..1017	CDD:188964	52/64 (81%)
		SAM_liprin-alpha1,2,3,4_repeat3	1037..1108	CDD:188967	48/70 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1157..1194
Liprin-alpha	NP_001260155.1	SMC_N	<37..408	CDD:481474	198/380 (52%)
		Smc	<255..>526	CDD:440809	133/273 (49%)
		SAM_liprin-alpha1,2,3,4_repeat1	942..1012	CDD:188961	63/69 (91%)
		SAM_liprin-alpha1,2,3,4_repeat2	1029..1094	CDD:188964	52/64 (81%)
		SAM_liprin-alpha1,2,3,4_repeat3	1114..1185	CDD:188967	48/70 (69%)