Protein Alignment PPFIA3 and syd-2

DIOPT Version :10

• Sequence 1: NP_003651.1
• Gene: PPFIA3 / 8541
• HGNCID: 9247
• Length: 1194
• Species: Homo sapiens
• Sequence 2: NP_509768.1
• Gene: syd-2 / 181255
• WormBaseID: WBGene00006364
• Length: 1139
• Species: Caenorhabditis elegans
• Alignment Length: 1235
• Identity: 533/1235 - (43%)
• Similarity: 713/1235 - (57%)
• Gaps: 224/1235 - (18%)

Human     3 CEVMPTISEDG-RRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHE 66
            |::|||||||| ..|..:........:|:||:.||.:|::|.|.|...:..|..|.||.:|:..|
 Worm    10 CDIMPTISEDGVDNGGPIDEPSDRDNIEQLMMNMLEDRDKLQEQLENYKVQLENAGLRTKEVEKE 74

Human    67 KDSLQRQLSI---ALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHE 128
            :|.::||..:   .||||...:|:||.|.:|||||::|||.||||||||||||||||||||||||
 Worm    75 RDMMKRQFEVHTQNLPQELQTMTRELCLLKEQLLEKDEEIVELKAERNNTRLLLEHLECLVSRHE 139

Human   129 RSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ 193
            |||||||:|||||:..|||||||||||||||||||||||||||||||:|:||||.|||||.....
 Worm   140 RSLRMTVMKRQAQNHAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVAMERVATLEEELSTKGD 204

Human   194 ETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGG----DSNRRTAELEEALERQRAEVCQLRE 254
            |..:|:.:::...:..||        .:|:.....|    :|..|..|::|||||.:.|:....:
 Worm   205 ENSSLKARIATYAAEAEE--------AMASNAPINGSISSESANRLIEMQEALERMKTELANSLK 261

Human   255 RLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319
            :...:..:.::||::|....||...|:|:..:|:..:.|..|||.|.|.||||.|.|:|:||||:
 Worm   262 QSTEITTRNAELEDQLTEDAREKHAAQESIVRLKNQICELDAQRTDQETRITTFESRFLTAQRES 326

Human   320 TSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAA 384
            |.:.|.|||||::||:|::..|.:|||...|.|.|:.|:::|.|:|:|||:||.:||:|.||:.|
 Worm   327 TCIRDLNDKLEHQLANKDAAVRLNEEKVHSLQERLELAEKQLAQSLKKAESLPSVEAELQQRMEA 391

Human   385 LNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHL 449
            |..||::..:.|||:::|:..::|.:.||:||.|||:||::|::|||.||||||||||:||||||
 Worm   392 LTAAEQKSVSAEERIQRLDRNIQELSAELERAVQRERMNEEHSQRLSSTVDKLLSESNDRLQLHL 456

Human   450 KERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR---------------- 498
            ||||.||::||.|::::...||:.|:....|::|..:.|.::.||:.||
 Worm   457 KERMQALDDKNRLTQQLDGTKKIYDQAERIKDRLQRDNESLRQEIEALRQQLYNARTAQFQSRMH 521

Human   499 ------------GRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKE 551
                        .:|.:|.::.   ||.:: |.|.|.       ..|.....|...:||.|.:::
 Worm   522 AIPFTHAQNIVQQQPQASIAQQ---SAYQM-YKQQPA-------QQYQTVGMRRPNKGRISALQD 575

Human   552 EPSK-------DWER---------------SAPA------GSIPPPFPGELDGSDEEEAEGMFGA 588
            :|:|       :|:|               |:|:      .::|.|     :.:.:.:.:.|..:
 Worm   576 DPNKVQTLNEQEWDRLQQAHVLANVQQAFSSSPSLADVGQSTLPRP-----NTAVQHQQDDMMNS 635

Human   589 ELLSPSGQ-----------ADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSG 642
            .:..|||.           .|.|.||.|||::|:|||.||:|||:||...|:.||:|| |.|...
 Worm   636 GMGMPSGMQGGMQGGMGGGQDAQMLASMLQDRLDAINTEIRLIQQEKHHAERVAEQLE-RSSREF 699

Human   643 LDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGAPRGE- 706
            .|..|                       .|..|:|| |.|........|.|.:|...:|..|.:
 Worm   700 YDDQG-----------------------ISTRSSPR-ASPQLDNMRQHKYNTLPANVSGDRRYDI 740

Human   707 --GPAIPGDTPPPTPRSARLERMTQALALQAGSLEDGGPPRGSE-------------------GT 750
              .|....|            ||.:.|        |..|.||..                   .:
 Worm   741 YGNPQFVDD------------RMVRDL--------DYEPRRGYNQFDEMQYERDRMSPASSVASS 785

Human   751 PDSLHKAPKKKSIKSS----IGRLFGKKEKGRMGPPGRDSSSL---AGTPSD-ETLATDPLGLAK 807
            .|.:....||:|..||    :||.|.||:        ..||.|   .|..|| |...|:  |..|
 Worm   786 TDGVLGGKKKRSNSSSGLKTLGRFFNKKK--------NSSSDLFKRNGDYSDGEQSGTE--GNQK 840

Human   808 LTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMA 872
                .|.|||.|:||||||||.:...|||.|:|||||:||||||||||||||||||||||||||:
 Worm   841 ----ADYDRRKKKKHELLEEAMKARTPFALWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMS 901

Human   873 NLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPE 937
            .|||.|||:|||||||||||||||||||||||||||||.::|.:
 Worm   902 ALSDQEIQKEIGISNPLHRLKLRLAIQEMVSLTSPSAPRTARLT--------------------- 945

Human   938 TKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSF 1002
                     ||:||||||::||||||.|||.||||.|||.|:|||||:||:|::||..|:|||:|
 Worm   946 ---------LAFGDMNHEYIGNDWLPCLGLAQYRSAFMECLLDARMLEHLSKRDLRTHLRMVDTF 1001

Human  1003 HRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGV 1067
            ||.||.|||||||::|||:|.|..||:.......|::|||||||..||..:||..|:.||.:||:
 Worm  1002 HRTSLQYGIMCLKKVNYDKKVLADRRKACDNINTDLLVWSNERVQRWVEEIGLGVFSRNLVDSGI 1066

Human  1068 HGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRK 1132
            ||||:|||||||.|..|..|||.:|:...||||||:|..|::   |.|...|   ...||.|.||
 Worm  1067 HGALIALDETFDASAFAYALQIGSQDVPNRQLLEKKFIGLVN---DHRQQSD---PHPRSGSSRK 1125

Human  1133  1132
             Worm  1126  1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPFIA3	NP_003651.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		10/20 (50%)
		Smc	39..>635	CDD:440809	279/669 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..233		5/34 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..583		13/85 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..819		55/224 (25%)
		PHA03307	630..>836	CDD:223039	63/235 (27%)
		SAM_liprin-alpha1,2,3,4_repeat1	835..905	CDD:188961	62/69 (90%)
		SAM_liprin-alpha1,2,3,4_repeat2	952..1017	CDD:188964	47/64 (73%)
		SAM_liprin-alpha1,2,3,4_repeat3	1037..1108	CDD:188967	41/70 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1157..1194
syd-2	NP_509768.1	SMC_prok_B	<42..606	CDD:274008	252/582 (43%)
		Smc	237..>515	CDD:440809	122/277 (44%)
		SAM_liprin-alpha1,2,3,4_repeat1	864..934	CDD:188961	62/69 (90%)
		SAM_liprin-alpha1,2,3,4_repeat2	951..1016	CDD:188964	47/64 (73%)
		SAM_liprin-alpha1,2,3,4_repeat3	1036..1107	CDD:188967	41/70 (59%)