Protein Alignment PPFIA3 and ppfia3

DIOPT Version :10

• Sequence 1: NP_003651.1
• Gene: PPFIA3 / 8541
• HGNCID: 9247
• Length: 1194
• Species: Homo sapiens
• Sequence 2: XP_012823004.1
• Gene: ppfia3 / 100491659
• XenbaseID: XB-GENE-6040150
• Length: 1214
• Species: Xenopus tropicalis
• Alignment Length: 1226
• Identity: 988/1226 - (80%)
• Similarity: 1084/1226 - (88%)
• Gaps: 44/1226 - (3%)

Human     1 MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGH 65
            |||||||||:||.||||....|:|  ..|:|||.||.||||||:||||.|:.|||||||||||||
 Frog     1 MMCEVMPTINEDNRRGSTYSSDDA--NFEQLMVNMLNERERLLDTLRETQESLATAQLRLRELGH 63

Human    66 EKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERS 130
            ||:||||||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||
 Frog    64 EKESLQRQLNIALPQEFAALTKELNLCREQLLEREEEISELKAERNNTRLLLEHLECLVSRHERS 128

Human   131 LRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQET 195
            |||||||||||||.|||||||||||||||||||||||||||||||:|||||||||||||:|:||:
 Frog   129 LRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERVAVLEEELEMSSQES 193

Human   196 LNLREQLSRRRSGLEEPGKDGD--GQTLANGLG----PGGDSNRRTAELEEALERQRAEVCQLRE 254
            :.|||||:|||||:::.|||||  ..|:.||..    .||    |.:||||.||:||.|:|||:|
 Frog   194 IALREQLARRRSGIDDGGKDGDTPSSTILNGSSHLELRGG----RESELEEMLEKQRLELCQLKE 254

Human   255 RLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319
            ||.::||||::|||||.||.::|.|:||.|:||||||||||||||||||||||||||||||||||
 Frog   255 RLTMMCRQMAELEEELNTAQKDLIKSEEVNAKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319

Human   320 TSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAA 384
            |||||.|||||||||||||||||||||:|||.|||:|||||||||||||||||||||||||||||
 Frog   320 TSLHDVNDKLENELASKESLYRQSEEKNRQLQEWLEDAKQKLQQTLQKAETLPEIEAQLAQRVAA 384

Human   385 LNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHL 449
            |:||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
 Frog   385 LSKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDEHNKRLSETVDKLLSESNERLQLHL 449

Human   450 KERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSAL 514
            |||||||||||:||||||||||||||||||||||:||:||||:|||||||||.|:||||||||||
 Frog   450 KERMGALEEKNTLSEEIANMKKLQDELLLNKEQLVAEIERMQLEIDQLRGRPSSTYSRSLPGSAL 514

Human   515 ELRYSQAPTLPSGAHLDPYVAGSG---RAGKRGRWSGVKEEPSK-------DWERSAPA---GSI 566
            |||||||||||.|:|:|.|  ||.   |..|:|||:.:|::|||       ||||:..|   .::
 Frog   515 ELRYSQAPTLPMGSHVDHY--GSTAVIRRPKKGRWAAMKDDPSKTRTLDEQDWERAQQANVLANV 577

Human   567 PPPFPGELDGSDEEEAEGMF-GAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQR 630
            ...|..:||||||::.:.:| .|:|||||||.|||||||||||||||||||||||||||||||.|
 Frog   578 AQAFEADLDGSDEDDRDTIFSSADLLSPSGQTDVQTLAIMLQEQLEAINKEIKLIQEEKETTELR 642

Human   631 AEELESRVSSSGLD-SLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKANH 694
            |||:||||:|..|| |||||||:.|:|.|:|||||||||||||||||||:.|.|||||| ||.||
 Frog   643 AEEIESRVTSGTLDGSLGRYRSASSIPTSVTTSTLASPSPPSSGHSTPRITPHSPAREG-DKFNH 706

Human   695 VPKEEAGAPRGEGPAIPGDTPPP-TPRSARLERMTQALALQAGSLEDGGPPRGS---EG------ 749
            :|||::   |.|...:..:|..| |||:.|||||||||||||.|||||...|.|   :|
 Frog   707 LPKEDS---RDEKALMQCETTAPLTPRAVRLERMTQALALQASSLEDGRDQRASLAADGLGGTNS 768

Human   750 -TPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLAGTPSDETLATDPLGLAKLTGPGD 813
             :.||||||.||||||||||||||||||||||..||:|||.|||||:||...||:||:||.||.|
 Frog   769 TSQDSLHKAAKKKSIKSSIGRLFGKKEKGRMGQMGRESSSAAGTPSEETSPADPMGLSKLGGPVD 833

Human   814 KDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTE 878
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   834 KDRRNKKKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTE 898

Human   879 IQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISW 943
            |||||||||||||||||||||||||||||||||:||||||||||||||||:||||||||||||||
 Frog   899 IQREIGISNPLHRLKLRLAIQEMVSLTSPSAPATSRTSTGNVWMTHEEMETLTATTKPETKEISW 963

Human   944 EQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLH 1008
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   964 EQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLH 1028

Human  1009 YGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLA 1073
            ||||||||||||||:|||||||||.|::|||||||||||.||..:||||:|.||.||||||||:|
 Frog  1029 YGIMCLKRLNYDRKELERRREESQNQLKDVMVWSNERVMCWVQAIGLKEYANNLQESGVHGALIA 1093

Human  1074 LDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKD 1138
            ||:|||::||||||||||||.||||:||||||:|||:||:|||||||||:|||||||||||||||
 Frog  1094 LDDTFDFNDLALLLQIPTQNTQARQVLEKEFSSLISMGTERRLDEDSAKTFSRSPSWRKMFREKD 1158

Human  1139 LRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC 1194
            ||||:||||||||||||:||..::.||.:.|||:|.||.||.|.|||.||||||||
 Frog  1159 LRGVSPDSAEMLPPNFRTAAVSSITSPAVQLRKMQSEGSTSTSPRADNVSVRTYSC 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPFIA3	NP_003651.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		15/21 (71%)
		Smc	39..>635	CDD:440809	496/615 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..233		16/36 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..583		28/70 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..819		140/206 (68%)
		PHA03307	630..>836	CDD:223039	151/217 (70%)
		SAM_liprin-alpha1,2,3,4_repeat1	835..905	CDD:188961	69/69 (100%)
		SAM_liprin-alpha1,2,3,4_repeat2	952..1017	CDD:188964	64/64 (100%)
		SAM_liprin-alpha1,2,3,4_repeat3	1037..1108	CDD:188967	56/70 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1157..1194		22/36 (61%)
ppfia3	XP_012823004.1	SAM_liprin-alpha1,2,3,4_repeat1	855..925	CDD:188961	69/69 (100%)
		SAM_liprin-alpha1,2,3,4_repeat2	972..1037	CDD:188964	64/64 (100%)
		SAM_liprin-alpha1,2,3,4_repeat3	1057..1128	CDD:188967	56/70 (80%)
		Smc	44..>649	CDD:440809	491/610 (80%)