Protein Alignment DNAJC14 and CG14650

DIOPT Version :10

• Sequence 1: NP_115740.5
• Gene: DNAJC14 / 85406
• HGNCID: 24581
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_649473.1
• Gene: CG14650 / 40566
• FlyBaseID: FBgn0037252
• Length: 970
• Species: Drosophila melanogaster
• Alignment Length: 704
• Identity: 170/704 - (24%)
• Similarity: 264/704 - (37%)
• Gaps: 231/704 - (32%)

Human    27 PSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPKHTQHPNPAHWLDPSHGPPGGPGPPRDAED-- 89
            |::.|:|.| :.|.:.....|...:.:..:: ||.::|..                .|..|..
  Fly   423 PNLQPQIKS-NKLNNPEKKRPLQPKNVNSNA-PKFSEHKT----------------TPVSANSSL 469

Human    90 ----------PDQSETSSEEESG---VDQELSKENETG-NQKDGNSFLSIPSACNCQGTPGIPEG 140
                      |..:.::|..:||   ::...|..|.|| |...|:|  |..|:.|
  Fly   470 QNHSNVLNFTPATNSSTSSRKSGSNKINSNASHSNHTGANTHAGSS--SSSSSVN---------- 522

Human   141 PYSEGGNGSSSNFCHHCTSPALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRH------ 199
             ||...|.|||:...:.:|                :|. |::    |||....|:|.|.
  Fly   523 -YSSNNNVSSSSAKRYSSS----------------NLN-PNN----SSGYSYSSKRNRSNAYSST 565

Human   200 RFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGE 264
            ..||..::....|       .:.|.::....                      ||:..|.:|
  Fly   566 NSPTHANSFSSNR-------NYELAKRIIHT----------------------WWIYTLKLL--- 598

Human   265 YVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGA 329
                                    .|:          ..:::..:..||..|....|     |..
  Fly   599 ------------------------TWL----------FYLVYDIVVLGFSMGYERIT-----LAY 624

Human   330 LLLLALALFL--------GFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRP 386
            :..||.|..|        |...:.||..        ||                      |....
  Fly   625 VAALAYARQLQKELKQNSGKPSIWWRSY--------WR----------------------RFDAR 659

Human   387 WQRLVRIVQWGWLELPWVKQNINRQGNAPVASGRYCQP-EEEVARLLTMAGVPEDELNPFHVLGV 450
            :.:..|:..|..    :.|:......:....:||..|. ||.:..||...|     .:.:.:|||
  Fly   660 FAKNSRLAVWRL----FYKRKPPETTSEQFKTGRLPQTGEEAMYSLLNCKG-----KDAYSILGV 715

Human   451 EATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAE----N 511
            ...:|..:::|.|:::||:||||||....||||||||:.|::::...|.|..|: :.:||    .
  Fly   716 PPDSSQEQIRKHYKKIAVLVHPDKNKQAGAEEAFKVLQRAFELIGEPENRLIYD-QSIAETLHTE 779

Human   512 ELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAE 576
            :....:::.||:||..:.||.||:.||.|..:|.|...:|...:||.||.|...|.|::||.|||
  Fly   780 KAWTELHDLLSQLQTKMAEAANTIRCSTCAQRHPRKLTERPHYAARECASCKIRHSAKDGDIWAE 844

Human   577 SSMLGLKITYFALMDGKVYDITEWAGCQRVGIS---PDTHRVPYHISFGSRIPGTRGRQRAT--- 635
            :||:||:..|.||||||||||||||.||:..:|   |::|.|.|.|..|::....:.:|:..
  Fly   845 TSMMGLRWKYLALMDGKVYDITEWANCQKGALSHLEPNSHMVQYRIVRGAQQQQQQQQQQQQQQQ 909

Human   636 ------PDAP-----------------PADLQDFLSRIFQVPPGQMPNG-NFFA 665
                  |..|                 .|.|.:||..::.   ||.|.. |.||
  Fly   910 QQHHQHPQQPHHDRGVHHPGGGVSGVSEATLHEFLDNLYS---GQHPGAHNAFA 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAJC14	NP_115740.5	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..148		27/136 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..229		12/69 (17%)
		DnaJ	443..504	CDD:395170	25/60 (42%)
		Jiv90	532..620	CDD:464360	46/90 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..702		4/9 (44%)
CG14650	NP_649473.1	DnaJ	708..769	CDD:395170	25/60 (42%)
		Jiv90	800..891	CDD:464360	46/90 (51%)