DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TUL1 and C09E7.8

DIOPT Version :9

Sequence 1:	NP_012890.1	Gene:	TUL1 / 853832	SGDID:	S000001517	Length:	758	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_498447.2	Gene:	C09E7.8 / 175931	WormBaseID:	WBGene00015642	Length:	1114	Species:	Caenorhabditis elegans

Alignment Length:	854	Identity:	155/854 - (18%)
Similarity:	236/854 - (27%)	Gaps:	362/854 - (42%)

- Green bases have known domain annotations that are detailed below.

Yeast    14 ILFLFFSSPGGDGVSSQYEF-NQLQRLKQQFRTEHNTFVNMTYTDSFRNITGL----------KL 67
            ::|.|         ||::|| |.|..:::....::....|:     |..||..          |.
Worm   513 LIFCF---------SSRFEFLNNLLEIQEGIHPKNENLANI-----FLGITSKPENLLPYLIDKS 563

Yeast    68 SYQDMLNNPLQNATYPLPGKDYDRWFPNQNYMVLPNDVIEAINTEV-WNTSNDDASNLFPPNITS 131
            .|||                            |||...:|.....| :|.|.||.:...|
Worm   564 RYQD----------------------------VLPTVPLERHRVRVTYNFSIDDETISEP----- 595

Yeast   132 TLLGKIDLVSNNKYEKIRMPVPRFYEPATD-FSE--DIPPEGETYWSEWPSYGELHNVSFQHGEI 193
                              .|||:..|..|: .||  |:..|..|.      ...|.||..|
Worm   596 ------------------TPVPQQLEKKTENCSECNDVRMEMNTV------KDVLQNVQKQ---- 632

Yeast   194 AIQISHMSNLQDNNNYLRRNFINKKNDRWKLLNLQIDFSDKAEK-EKH------SIYSK-AVYDI 250
                  :.|:|.|:.......:...|   |..|.:....|:..| .||      ::.|| ...:.
Worm   633 ------LKNMQQNSEQFETKLVASDN---KTKNFEKQLEDERRKNNKHLESSRKTLISKNEQLEA 688

Yeast   251 QRGRILSIS------QSSKFHSLFALPHYMSFQNDYNEKIFNDVKELVDEFWNFTDYTDVM---T 306
            .:.|..::|      |:.||.  .|..|.:..|.:.:.|   ||.:..|:........::.   .
Worm   689 LKRRATALSNCQAENQTLKFK--IAEHHLLEKQLNISNK---DVTQARDQLSGQISELEIQLKSE 748

Yeast   307 MKDVQDAYNNANFKC---------------EYLIFLQLEPWNQYTRDQIKLIDDELNWPLGRPAN 356
            :|.||.........|               |.|...|||.    ...|::...||:|..:.:...
Worm   749 LKTVQHLKKEQTISCNLTNEITKLKDQIEREKLCSKQLEK----EISQLRTEADEMNIVMTQSLE 809

Yeast   357 LSSLPPINVV-------SGLLYSPDCGVRLGLH-------------------------------- 382
            :.:|...:..       :.||.:   ..:|.:.
Worm   810 MENLQLRDATKKFETENASLLKT---NQQLSIQNEEQKRLIQVLLEKQQTAPSSSDFPVPSTQMT 871

Yeast   383 -NVKGTRYEL-KIMSIRKHLLFGIALFAAQIYLLLTQMHHTNTPSMVNKISFYCFSMINLVDGSL 445
             |.:.:|.:| |...|:.....||.|..|:              :||.|:     :.:|...|
Worm   872 DNEENSRQQLWKYQKIKDSFRDGIKLRKAE--------------AMVKKL-----TSLNRDPG-- 915

Yeast   446 ATLYFVAASVVPELYLPLVISAFSCFILASIFEIRYLISIYASQVNEQNVGIINLLR-GNTGTYD 509
                 |......||.                 ..:.|.|.|...:.      :|:|: .|.|:.|
Worm   916 -----VHQMAHRELE-----------------NFKKLTSHYLQAIE------MNILKIKNNGSSD 952

Yeast   510 -ENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFLILSSTSWPRQLRMVFEYILIFILNSYWIPQI 573
             |..|......||            ||                                    :.
Worm   953 LEQLPEAPKFSDE------------FM------------------------------------RF 969

Yeast   574 FRNAV-------KGIPSRRERARSSIGGNRSQNKMPLLWSFVIGTTIIRSLPVVYVFTYSSNVFR 631
            :|||.       ....|...|...|.|.:                  |.::|    .|.|....:
Worm   970 YRNATGKQTLTSASFSSGNSRGTQSYGSS------------------ISTMP----STSSRGNVQ 1012

Yeast   632 HHKDVHFVVFLSLWLLFQISILYSQDVLGSRWFLPKHTIPDGYSYFKPLSNEYISEHGGGTAEHT 696
            ||..               |.:..|.:           .|.|.|.......:..|:....||..|
Worm  1013 HHSG---------------SAVRGQSI-----------TPTGLSQVPMSPRKLFSQPNIVTASIT 1051

Yeast   697 ------VDCAICMSDVPIYIEEIPETHKVDQHSYMVTPCNHVFHTSCLENWMNYKLQCPVCR--- 752
                  .:||||:.::..:.|.|.            ..|...||..|...|:|.|.:||.||
Worm  1052 STELDDTECAICLDEMTNFKETIK------------CQCRRRFHLECATKWLNEKRECPTCRKLL 1104

Yeast   753 ---SPLPPL 758
               |..|||
Worm  1105 LNPSDYPPL 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TUL1	NP_012890.1	COG5540	320..758	CDD:227827	86/514 (17%)
C09E7.8	NP_498447.2	Smc	<626..>855	CDD:224117	45/253 (18%)
		zf-RING_2	1058..1101	CDD:372655	15/54 (28%)
		RING-H2 finger (C3H2C3-type)	1060..1100	CDD:319361	15/51 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910