Protein Alignment TUL1 and RNF145

DIOPT Version :9

• Sequence 1: NP_012890.1
• Gene: TUL1 / 853832
• SGDID: S000001517
• Length: 758
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Alignment Length: 720
• Identity: 134/720 - (18%)
• Similarity: 239/720 - (33%)
• Gaps: 274/720 - (38%)

Yeast   210 LRRNFINKKND-RWKLLNLQIDFSDKAEKEKHSIYSKAVYDIQRGRILSISQSSKFHSLFALPHY 273
            :.|:.|:..|. .|   :||:....|.:|:|:::.:|...:    .:|:::        ..:|..
Human     1 MHRDRISPSNSPTW---SLQVFSKKKKKKKKNNMAAKEKLE----AVLNVA--------LRVPSI 50

Yeast   274 MSFQNDYNEKIFNDVKELVDEFWNFTDYTDVMTMKDVQDAYNNANFKCEYLIF------------ 326
            |.....|.              |:.:.:...:....:.   ||..|:.:||..
Human    51 MLLDVLYR--------------WDVSSFFQQIQRSSLS---NNPLFQYKYLALNMHYVGYILSVV 98

Yeast   327 -------------------LQLEPWNQYTRDQIKLIDDELNWPLGRPANLSSLPPIN-----VVS 367
                               |.|...:|.:||.::   .||.:....|..|..| .:|     ::.
Human    99 LLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVR---SELEFAYEGPMYLEPL-SMNRFTTALIG 159

Yeast   368 GLLYSPDCGVRLGLHNVKGTRYELKIMSIRKHLLFGIALFAAQIYLLLTQ--MHHTNTPSMVNKI 430
            .|:....|..               :|..::     |.||:|.:..||.:  :....|..::||
Human   160 QLVVCTLCSC---------------VMKTKQ-----IWLFSAHMLPLLARLCLVPLETIVIINK- 203

Yeast   431 SFYCFSMINLVDGSLATLYFVAASV----------------VPELY--LPLVISAFSCFILASIF 477
                |:||..   .|..|||:.:::                |.|:|  |.|.:|.::..::..:|
Human   204 ----FAMIFT---GLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLF 261

Yeast   478 EIRYLISIYASQVNEQNVGIINLLRGNTGTYDENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFL 542
            .:.:|: ::|.|:.               :|...|.:||....              :|.:|...
Human   262 MVFWLV-LFALQIY---------------SYFSTRDQPASRER--------------LLFLFLTS 296

Yeast   543 ILSSTSWPRQ-LRMVFEYILI---------FILNSYWI----PQIFRNAVKGIPSRRERARSSIG 593
            |....|.|.. |.:||....:         |.|..|..    |.:.|...:|:.......::.:.
Human   297 IAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLI 361

Yeast   594 GNRSQNKMPLL--WSFVIGTTIIRSL-----PVVYVFTYS--SNVFRHHKDVHFVVFL------- 642
            ..:..::..||  ..|::..:|::|:     |:|.....|  .::::|.:.|...:||
Human   362 ELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYM 426

Yeast   643 ----------SLWLLFQI--SILYSQDVLGSRWFLPKHTIPDGYSYF-------KPLSN-EYISE 687
                      ..|||..|  |||.|..|||:.:.         |..|       :|:.| :.:..
Human   427 AYMICQFFHMDFWLLIIISSSILTSLQVLGTLFI---------YVLFMVEEFRKEPVENMDDVIY 482

Yeast   688 HGGGT----------------------AEHTV-----------------------------DCAI 701
            :..||                      .|.||                             |...
Human   483 YVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVN 547

Yeast   702 CMSDVPIYIEEIPETHK-------VDQHSYMVTPCNHVFHTSCLENWMNYKLQCPVCR------S 753
            .:..:||..:|..|.|.       .|..|.::|||:|.||..||:.|:..:..||:|.      |
Human   548 KIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSS 612

Yeast   754 PLPPL 758
            .||.|
Human   613 QLPGL 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUL1	NP_012890.1	COG5540	320..758	CDD:227827	115/607 (19%)
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	100/597 (17%)
		zf-rbx1	<564..605	CDD:289448	13/40 (33%)
		zf-RING_2	565..605	CDD:290367	13/39 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7680
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030