Protein Alignment MICALL1 and MICAL-like

DIOPT Version :10

• Sequence 1: XP_011528773.1
• Gene: MICALL1 / 85377
• HGNCID: 29804
• Length: 929
• Species: Homo sapiens
• Sequence 2: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Alignment Length: 1080
• Identity: 299/1080 - (27%)
• Similarity: 437/1080 - (40%)
• Gaps: 247/1080 - (22%)

Human     1 MAGPRG--------ALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLDFDSLSKD 57
            |:..||        ||..|||...:||.||::.::::|:|:|||||||:|..||||:|||.|..|
  Fly     1 MSDRRGTKVGTGTKALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKAD 65

Human    58 NVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFCSPGQAGVSPPRKGL 122
            :::|||.|||..|||.||||||||..||||..|||.|||:||:||:|...           .|.|
  Fly    66 DIYENNDLAFTTAEKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVL-----------GKSL 119

Human   123 APCSPPSVAPTPVEPEDVAQGEELSSGSLSEQGTGQTPSSTCAACQQHVHLVQRYLADGRLYHRH 187
            .       .|.|.||    .|||...........|......|..|...|.|.:|.|...|.|||.
  Fly   120 K-------HPKPEEP----LGEESEPPQKVMHIVGMPRRDKCQKCNLPVFLAERVLVGKRAYHRT 173

Human   188 CFRCRRCSSTLLPGA-YENGPEEGTFVCAEHC-----------ARLGPGT--------------- 225
            |.:|.||||.|.||: ||.  |.....|.|.|           .:|...|
  Fly   174 CLKCARCSSLLTPGSFYET--EVNNIYCCETCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSD 236

Human   226 ----------------RSGTRPGPFSQPKQQHQQQ-----------LAEDAKDVPGGGPSSSAPA 263
                            |:..:|..|..|..:.:|.           |:|:.|       .|..|.
  Fly   237 YSEAEDKQEDLEDNDIRTTDKPENFQPPSNKDEQNNELTINPVNPILSEERK-------ISFIPL 294

Human   264 GAEADG-----PKASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASESTTPAPPTPRPRS 323
            ..|..|     .|::...:|.||.||:|       ::.|......|..:.:.....:|....|:.
  Fly   295 DEEDGGLIEQYNKSTTPVKPAIPEKPKV-------STLPLDDEQHAGVEQNNDLAVSPENDIPKE 352

Human   324 SLQQENLVEQAGSSSLVNGRLH--------------ELPVPKPRGTPKPSEGTP---------AP 365
            .|:..::........||...:|              :..:|:.:..|.|...|.         :|
  Fly   353 KLKISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKPEDHISP 417

Human   366 RKDPPWITLVQAEPKKKPAPLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTASLE-SKPYNPFEE 429
            ||:....:..:: ..|:...||.......|.....:.:...|:.....:|....: ||..||| :
  Fly   418 RKENKIFSNTES-CSKQEGVLPKQMDLESPKDKVIETKASETDYPEDLNPFKDDDSSKGANPF-D 480

Human   430 EEEDKEEEAPAAPSLATSPALGHPESTPKSLHPWYGITPTSSPKTKKRPAP------RAPSASPL 488
            ..:|:.|...|.|:..:...:..|...|    |..|::..|:|..|...:|      :.|..:|.
  Fly   481 SSDDEVELLKAIPAQQSKGKVVPPRPPP----PKIGLSSISNPSEKPHSSPTLSHGKKMPMPTPR 541

Human   489 DNVFGSIISISHEEINWCPAVPVPELVAARAACSSPLPPHCRS------GAEE-----------G 536
                   ||||..:   .||.|:.. ...:::.||....|..|      ||::           |
  Fly   542 -------ISISKTQ---TPAKPMTH-QGQKSSISSSSSEHLNSIRTFDRGADDRGSSISLPSANG 595

Human   537 P--PLFLWHSQALHASRLSHSEP-PSATPSPALSVESLSSESASQTAGAELLEPPAVPKSSSEPA 598
            |  ||           |.|...| .|...||..|:.|::|....:.. |.|  ||......|:|.
  Fly   596 PRKPL-----------RASVGSPLRSEESSPTTSLSSITSPMRKKRQ-APL--PPIQTDFDSDPG 646

Human   599 VHAPGTPGNPVSLSTNSSLASSGELVEPRV-----EQMPQASPGLAPRTRGSSGPQPAKPCSGAT 658
            ..         .||.........:|..|.:     ..:|.....|:.....||....:...|.|
  Fly   647 FS---------KLSDEQKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNA- 701

Human   659 PTPLLLVGDRSPVPSPGSSSPQLQVKSSCKE-------NPFNRKPSPAASPATKKATKGS-KPVR 715
            ...:.:|..|..||   .:.|:..|:.|.::       |.|:|..||...   .|:|.|. |..:
  Fly   702 DEEVNVVYRRILVP---PTQPENTVERSKEDQKSPIVYNDFDRNVSPLGH---NKSTHGKWKRRK 760

Human   716 PPAPGHGFPLIKRKVQADQYIPEEDIHGEMDTIERRLDALEHRGVLLEEKLRGG----------- 769
            .|||  ..|:..|||.  |.:|.::|..|.:.|..:...||.:||:||:.:|..
  Fly   761 GPAP--AVPIPPRKVL--QRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSLDATDTD 821

Human   770 -------LNEGRE-DDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEYELRCLLNKP 826
                   |...:| :|:::..|:|::||:.|.||::||:|:.:|..|||.|||:|:|:|.|:.:|
  Fly   822 GPESAEVLTNSKEVEDLILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQP 886

Human   827 EKDWTEEDRAREKVLMQELVTLIEQRNAIINCLDEDRQREEEEDKMLEAMIKKKGEALAGDEAE- 890
            |.:.|:.|:|.|:||:..||.::|.||.:|:.|:.||.||..||    ..||.:......:..|
  Fly   887 EHNKTDSDKAHEEVLINRLVKVVEMRNEVIDSLETDRVREARED----MSIKNRLHIYNSEREEP 947

Human   891 --FQREAEPEGKKKGKFKTMKMLKLLGNKRDAKSKSPRDK 928
              ..|.|:...||..| |..|.|| ..||.....||..||
  Fly   948 PAHPRSADKSSKKLSK-KERKKLK-EENKLGKGKKSDLDK 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICALL1	XP_011528773.1	CH_MICALL1	4..110	CDD:409101	62/113 (55%)
		LIM_Mical_like_1	164..218	CDD:188828	24/54 (44%)
		PHA03247	<253..724	CDD:223021	112/538 (21%)
		bMERB_dom	744..865	CDD:463467	50/139 (36%)
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	60/103 (58%)
		LIM_like_1	146..207	CDD:188784	25/62 (40%)
		PTZ00449	<411..727	CDD:185628	76/359 (21%)
		bMERB_dom	785..933	CDD:463467	54/151 (36%)