Protein Alignment STE6 and Mdr50

DIOPT Version :10

• Sequence 1: NP_012713.1
• Gene: STE6 / 853671
• SGDID: S000001692
• Length: 1290
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Alignment Length: 1327
• Identity: 362/1327 - (27%)
• Similarity: 612/1327 - (46%)
• Gaps: 129/1327 - (9%)

Yeast     7 KTTKHYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGR----VFDLLSVFVANGSHQG- 66
            |...::.:|||.. :.|..|.:|.::..|||||.....|::.|.    :.||..:..:..|::.
  Fly    69 KQVSYFQLFRYAT-KKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRAD 132

Yeast    67 ------LYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYD 125
                  |..::.|.|:....:|...:...:||:|.:.:....|...|||:...:.|.: .|:|||
  Fly   133 DAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQ-DMKWYD 196

Yeast   126 NNEKLLGDF-TQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITF 189
            .|:.  |:. :::|..:.::....||...:....|||....|..:|...|.|:|:.|.|.| :||
  Fly   197 FNQS--GEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLP-LTF 258

Yeast   190 F-----AVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTF 249
            .     ||..||:    ::||.:..:.||.:...:::..:.|:.:..:..|...:||.::.....
  Fly   259 IAMGLVAVATSRL----AKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKIL 319

Yeast   250 FIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKG-------KLNINDVITCFHSCIMLGSTL 307
            .||...|.....|:|.|.....:...||:|..::.||       ..:...:||.|.| :|:|| :
  Fly   320 NIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFS-VMMGS-M 382

Yeast   308 NNTLHQIVV----LQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPS 368
            |..:....:    :.||..|  |:..:::...:.||::   .....|:...:.:.|..|.|.||:
  Fly   383 NIGMAAPYIEAFGIAKGACA--KVFHIIEQIPEINPID---GEGKKLNEPLTTIEFKEVEFQYPT 442

Yeast   369 RPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIE 433
            ||..::|..::|....||...:||.||.||||...|:.||||...|::..||.|::.:|...|..
  Fly   443 RPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRS 507

Yeast   434 NITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETL 498
            .|.||.|...||..::.:||..|..|:.|..          |:.|...|....||..||.|.:||
  Fly   508 RIGVVGQEPILFATSIYENIRYGREDATREE----------IEAAAAAANAAIFIKKLPKGYDTL 562

Yeast   499 IGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHE 563
            :|..|..|||||:||:|||||.|||..||.||||.||||......:..|:.....|:||||:.|.
  Fly   563 VGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHR 627

Yeast   564 LSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVE 628
            ||.:...|.:.::.:||||||||..||:           .|::.|.:   :|.|:..|..
  Fly   628 LSTVRRADRIVVINKGEVVESGTHQELM-----------ELKDHYFN---LVTTQLGEDD----- 673

Yeast   629 SFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESST 693
                       ||.||..|       ..|:....|..:....:|..|:|:....:..:||.:..
  Fly   674 -----------GSVLSPTG-------DIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKK- 719

Yeast   694 GPQLLSIIQIIKRMIKSIRYKK----ILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDG--- 751
             .:.:.....:|.|::.::..|    .:.:|.:.|:|.|...|:|:..|..:|: |:...|.
  Fly   720 -KKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQ-ILSVKDNDQY 782

Yeast   752 -KTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGEN 815
             :..|:.|    ||..|......||..|.:.:......|.....||..:.|.:.|:.:.||..:.
  Fly   783 VRENSNQY----SLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKA 843

Yeast   816 NKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSA 880
            |....:.|.:..|...::....:.:..:...::...:|:..::...|.|.||.::..|.|:|...
  Fly   844 NGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFY 908

Yeast   881 IYGGILQKCETDYKTSVAQLENC---LYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRA 942
            :...::.|   :...|...:|||   ..::|:||:|:..|..|..|...|..:.|...:|:.:..
  Fly   909 MQRTLMAK---ENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNT 970

Yeast   943 IATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISR 1007
            ...|....:...::....|...|||...|:.......::|.....|:....|..:.::..|::.:
  Fly   971 HFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQK 1035

Yeast  1008 GQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKN 1072
            |..||..|:..|..:.:.::       ..|::...:|   .:..|....:.|:||:.....|.|.
  Fly  1036 GVSAAKTIFTFLRRQPSIVD-------RPGVSRDPWH---SEGYVRFDKVKFSYPTRSEIQVLKG 1090

Yeast  1073 MNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKP 1137
            :...:..||.:.::|.||.||||.:.|:.:.|:.:.|...||..||.:.::|:||.::.:|.|:|
  Fly  1091 LELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEP 1155

Yeast  1138 LLFNGTIRDNLTYGLQD---EILEIEMYDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQR 1197
            :||:.|||:|::||  |   .:.:.|:..|.|...||:|:.:.|.|.|||:..  ..|||||.||
  Fly  1156 ILFDRTIRENISYG--DNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQR 1218

Yeast  1198 LCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKD 1262
            :.|||||:|..||::|||.|||||:.|..::.:.:........|:.|.|....:...:.|.|.::
  Fly  1219 IAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFEN 1283

Yeast  1263 GKVVERGNFDTLYNNRGELFQIVSNQS 1289
            |.|.|.|:...|..|||..:.:...||
  Fly  1284 GLVCEAGDHKQLLANRGLYYTLYKLQS 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STE6	NP_012713.1	MdlB	1..592	CDD:440747	187/612 (31%)
		MdlB	702..1290	CDD:440747	158/604 (26%)
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	360/1323 (27%)