Protein Alignment STE6 and Mdr49

DIOPT Version :10

• Sequence 1: NP_012713.1
• Gene: STE6 / 853671
• SGDID: S000001692
• Length: 1290
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Alignment Length: 1364
• Identity: 351/1364 - (25%)
• Similarity: 601/1364 - (44%)
• Gaps: 210/1364 - (15%)

Yeast    11 HYHIFRYVNIRNDYRLLMIMIIGTVATGLVP-------AITSILTGRVFDL--------LSVFVA 60
            ::.:|||......:.|::.:::.|.|:..:|       ..||:|..|...:        |.:|
  Fly    31 YFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMF-- 93

Yeast    61 NGSHQGLYSQLVQRSMAVM----ALGAASV---PVMWLSLTSWMHIGER----QGFRIRSQILEA 114
            .|..|...:...:.:.|::    |.|..|:   ..|:|.:|..:.:..|    |..|||...|||
  Fly    94 GGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEA 158

Yeast   115 YLEEKPMEWYDNNEKLLGDF-TQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTL 178
            .|.: .:.|||.:..  .:| :::...:::|:....|...|....::.....:.::|.|.|.|||
  Fly   159 MLRQ-DIAWYDTSSG--SNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTL 220

Yeast   179 IILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEII 243
            ::|...|.|.....|.:|:....:|||....|.||.::....:..:.|..:..|..|:::|.:::
  Fly   221 VVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLL 285

Yeast   244 LNC-NTFFIKSCFFVAANA--GILRFLTLTMFVQGFWFGSAMIKKGKLNIND-----------VI 294
            :.. ||...|..:....||  .::.:|.:.:.:   |:|..:|    |:..|           ||
  Fly   286 IPAENTGRKKGLYSGMGNALSWLIIYLCMALAI---WYGVTLI----LDERDLPDRVYTPAVLVI 343

Yeast   295 TCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNK-------TVAHQFPLDY 352
            ..| :.||....|......:..:.....|.:.:..::...|:.:|:::       |..|
  Fly   344 VLF-AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGH------ 401

Yeast   353 ATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSIS 417
                :.|..:.|.||:||...:||.::::...||....||.||.|||||..|:.||||...||:.
  Fly   402 ----IRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVK 462

Yeast   418 INGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMA 482
            ::|.:::|::...|...|.||.|...||..|:.:||..| ..|...||         |:.|.:.|
  Fly   463 LDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYG-RPSATQAD---------IEKAARAA 517

Yeast   483 LLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKA 547
            ....||..||.|.:|.:|..|..:||||:||:|||||.:|...:|.||||.||||......:..|
  Fly   518 NCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582

Yeast   548 IRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELL--------------------A 592
            :....:|.||:::.|.||.|.:.|.:..:|:|.|.|.||..||:                    |
  Fly   583 LELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEA 647

Yeast   593 DPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFY 657
            |.............:.||.:|..|.|.||:.           |.|:|.:  |....|.    .|.
  Fly   648 DEGAVAGRPLQKSQNLSDEETDDDEEDEEED-----------EEPELQT--SGSSRDS----GFR 695

Yeast   658 EAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLL 722
            .:..:||.:.|.::            |:.|...|.     :|..|::|......|:   :::|.:
  Fly   696 ASTRRKRRSQRRKK------------KKDKEVVSK-----VSFTQLMKLNSPEWRF---IVVGGI 740

Yeast   723 CSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCC 787
            .|::.|||.|::...|.... ||:...|.....:..| |.|::.:|:....|:.|..:.::....
  Fly   741 ASVMHGATFPLWGLFFGDFF-GILSDGDDDVVRAEVL-KISMIFVGIGLMAGLGNMLQTYMFTTA 803

Yeast   788 SEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTI 852
            .......||......:..:::.:|..|.|....:.:.:.:|..:::......:..|...|....:
  Fly   804 GVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVV 868

Yeast   853 GLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTNIKTIK-- 915
            |::...|..|:.:|:.:...||:.:...:.|..:.|.....|.|:.:......:.:|||:|:.
  Fly   869 GMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGL 933

Yeast   916 CLQAEFHFQLTYHDLKIKMQQIASKRAI-------ATG-------FGISMTNMIVMCIQAIIYYY 966
            ||:.:.   |..:..:|....||.:|.:       |.|       :||||             ||
  Fly   934 CLERQV---LDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISM-------------YY 982

Yeast   967 GLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILD----------- 1020
            |..||.......:::......|:|........::..|:::....:|.   |::|
  Fly   983 GGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAG---RLMDLFKRTSTQPNP 1044

Yeast  1021 --EKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTL 1083
              ..:||:|                  |.:..|| .:|:.|.||:.....:.:.:|..:....|:
  Fly  1045 PQSPYNTVE------------------KSEGDIV-YENVGFEYPTRKGTPILQGLNLTIKKSTTV 1090

Yeast  1084 GIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNL 1148
            .::|.||:||||.|.||.:.|:...|.:.:.|....::.|.:||.::.:|.|:|:||:.||.:|:
  Fly  1091 ALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENI 1155

Yeast  1149 TYG--LQDEILEIEMYDALKYVGIHDFVISSPQGLDTRI-DTTLLSGGQAQRLCIARALLRKSKI 1210
            .||  .:|::...|:.:|.|...||:|:.:.|||.|||: .|:.|||||.||:.|||||:|..||
  Fly  1156 AYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTSQLSGGQKQRIAIARALVRNPKI 1220

Yeast  1211 LILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTL 1274
            |||||.|||||..|..::.:.:.:.......:.|.|....:|:.:.|.|||.|.|||.|..|.|
  Fly  1221 LILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDEL 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STE6	NP_012713.1	MdlB	1..592	CDD:440747	172/648 (27%)
		MdlB	702..1290	CDD:440747	157/605 (26%)
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	169/631 (27%)
		MdlB	720..1299	CDD:440747	158/608 (26%)