back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SYDE1 and RhoGAP100F

DIOPT Version :10

Sequence 1:	XP_047295535.1	Gene:	SYDE1 / 85360	HGNCID:	25824	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	256/930 - (27%)
Similarity:	360/930 - (38%)	Gaps:	277/930 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    21 RKKSDAKERGHPA----QRPEPSPPE-------------------PEPQAPEGSQAGAEGPSSPE 62
            |::...:..|.|.    .|||..||.                   |.|::....:.|    ...|
  Fly   260 RQRRGNRGTGSPGPPTLSRPEQKPPPVVVIKRDLRDEDLDETDRMPRPRSSRDRRTG----DGRE 320

Human    63 ASRSPAR-GAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIW-YNPIPEEDPRPP-- 123
            .:.|.:| |..|.:..|.|.:..:      ...:.|.|....|||..  | |.|     |.||
  Fly   321 MTESRSRLGLGLNNYSPQSEQLDM------YYNTRGGGGGAMGEPPN--WGYKP-----PPPPSS 372

Human   124 ------------AP------------------------EPPGPQPGSAE--SEGLAPQGKNKLPI 150
                        ||                        :|.||..|.:.  |.|....|..:...
  Fly   373 VITEQPTKAHAFAPSHAYYQNAGTLESLAEKVHAFYPGQPGGPPVGPSRRMSTGTGNVGLAQQHA 437

Human   151 PFPKVSTSSTSLP------FRVAPASHSLLPEEHQPHT--------------------------- 182
            .||: |.|...||      :..:...||||....:|.|
  Fly   438 RFPR-SGSDQHLPRVEYSDYSNSLGRHSLLRSSLKPGTTGGAPMQVGVGGTLGRYGRYDQQRAGV 501

Human   183 ----PSLQGSTSLTSPPRQMLPEEHQPHTLLPARGTPASHSFPSGEHQPHPPPLSPGSW------ 237
                |...|:.|||...|..|.........:..|  |:.:.:    ::|....:|.||.
  Fly   502 SKYGPPSGGAQSLTRRSRPNLDYSSDTEATIGPR--PSYYYY----NRPAIGSMSRGSGGAGGGV 560

Human   238 --TLKSALHTGAAPA----SPPTKASRTKSPGPARRLSIKM-------KKLPE--------LRRR 281
              ...:||..|||..    |.|.:...|:..|...|:..::       ...||        ||:|
  Fly   561 GAASTAALLAGAADLNKFNSLPRERPGTRLQGIRSRMGDRLVDENDGNTSAPEFDVRRGRDLRQR 625

Human   282 LSLRGPRAGRERERA----APAGSVI--------------------------------------S 304
            ::........:..||    ||:.|.|                                      |
  Fly   626 ITASPSIFTADEYRAWLRRAPSSSAIAEQMRMTRDMFAQPRAQRFSCSAENIHDALRNTESIYSS 690

Human   305 RYHL-------------------------DSSVGGPGPAAGP------------GGTRSPRAGYL 332
            |.|:                         ...:||.|....|            .|..||....|
  Fly   691 RNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQLLELSAGPASPSGSIL 755

Human   333 SDGDSPERPAGPPSPTSFRPY---EVGPAARA-----PP----AALWGRLSLHLYGLGGLRPAP- 384
            |.| ..:.||..||.|..||:   ::.||..|     .|    ..:.|.|.:||....|||.||
  Fly   756 STG-GHQSPAPTPSATLPRPHRQIDINPAEFAKYKLDKPIVDIGGISGMLWIHLLAGRGLRTAPE 819

Human   385 GAT-------PRDLCCLLQVDGEARARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGV 442
            ||.       .|||.|:::.|...:||| .:|.|......|.:|.|:|...:.|..||.:||| .
  Fly   820 GAAGTATQGQTRDLYCVIECDRVHKART-VVRSGDLQFDWDESFELDLVGNKQLDVLVYSWDP-Q 882

Human   443 RRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAK------LTLSEQQEAPA--TAEPRVFG 499
            .||:.|.:|.:.|.::.|.....|||:::||:|.:|.:      |.|.:::..|:  ...|.:||
  Fly   883 HRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYIRMRHTDPLALYKRRGLPSLRAGYPTLFG 947

Human   500 LPLPLLVERE--RPPGQ--VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAV 560
            ..|..:|.||  ..||.  ||:::::||.::|||||.::|||||||||..|:.||:||||:|.||
  Fly   948 ADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAV 1012

Human   561 CLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPD 625
            .|:.:..||||||||:|||||||||.||.|:.|:::.::|:|...|:......:....:|.|||.
  Fly  1013 ELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPR 1077

Human   626 VERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKH 690
            ..||||..|||||.||.|....|:|:.|.||...||        |....:.|:.||  :.:|...
  Fly  1078 ANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGP--------PLMLHSASAQPG--ADIDHAQ 1132

Human   691 HIEVLHYLLQSWPDPRLPRQ 710
            .|.||.||||.||.|:...|
  Fly  1133 PIAVLKYLLQIWPQPQAQHQ 1152

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.