Protein Alignment SHANK3 and shn-1

DIOPT Version :10

• Sequence 1: NP_001358973.1
• Gene: SHANK3 / 85358
• HGNCID: 14294
• Length: 1806
• Species: Homo sapiens
• Sequence 2: NP_001379494.1
• Gene: shn-1 / 174739
• WormBaseID: WBGene00006444
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 1758
• Identity: 410/1758 - (23%)
• Similarity: 607/1758 - (34%)
• Gaps: 665/1758 - (37%)

Human    84 VVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERL 148
            |.:::.:|:|...|.|.:.....:|..|:::|..|..:|..|.|||||.||..|||||||.|:|.
 Worm     8 VNLQIFVPELNVRKFLAVTQNDFIWDVKRKLLATLPQALPQAFNYGLFLPPCDGRAGKFLLEDRT 72

Human   149 LQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKG 213
            :::||  ....:||||.:||:|||....:|:||...:|||..|||||||||..:.:||.::..:|
 Worm    73 IRDYP--FTDCVPYLELKYKKRVYKMLNLDEKQLKAMHTKGQLKKFMDYVQQKNNEKVEKMCSQG 135

Human   214 LDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLL 278
            ||.||||. .||.||:|||.:.|...::..|..||||:|||..:|.||:|.|....:...:.||:
 Worm   136 LDANFHDA-QGETPLTLAAGIPNNRAVIVSLIGGGAHVDFRNSEGQTAMHKAAFLSSFENVKTLI 199

Human   279 DLGASPDYKDSRGLTPLYHSAL-GGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLE 342
            :|||||:|:|..||||||::.| ...:....|:||.:.|.:|:||.:|..||||||:.|..:|:|
 Worm   200 ELGASPNYRDPIGLTPLYYNMLTADSNDQVAEILLREAADIGVTDMHGNHEIHQACKNGLTKHVE 264

Human   343 HLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELA 407
            |||::|..:.|:|.:||:.||:||:.|:..||||||||||:....|...|||..|:.|.||..:|
 Worm   265 HLLYFGGQIDAENVNGNSPLHVCAVNNRPECARVLLFRGADHLAVNKQGQTALHVSHIVGNPGVA 329

Human   408 EVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLP 472
            :|::.|.....||:|.||.|:.|||      |:|....:||.|
 Worm   330 DVVQAHNPKSSVPYRGTPQYSTRRR------LSSTITRRRSMS---------------------- 366

Human   473 HQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISPSGPGGPGPAPGPGPAPPAPPAPPPRG 537
                                :|:|......|..||  ...||....|:|.|..:......|...|
 Worm   367 --------------------QSSICSQDVYRTPQS--VRKGPMSAAPSPSPSRSSRTTITPSEYG 409

Human   538 PKRKLYSAVPGRKFIAVKAHSPQGEGEIPL-HRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVE 601
            ..|:  |.:          .|.:|.|.|.. |.....::|.|..|      ||
 Worm   410 TMRR--SGM----------DSMRGGGMIAAGHETNIARILVIPRG------VK------------ 444

Human   602 EVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRGAKA 666
                                                                  ||||:|||||.
 Worm   445 ------------------------------------------------------GFGFILRGAKH 455

Human   667 ETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNR 731
            ......|.||...||||:.|.||:.|:|.|||||.||:|:|::|::|.:..|.:||..|:|.|:.
 Worm   456 VAMPLNFEPTAQVPALQFFEGVDMSGMAVRAGLRPGDYLLEIDGIDVRRCSHDEVVEFIQQAGDT 520

Human   732 LVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAA 796
            :.:||::|.......|......||...:..:.:...:.|......:.:|:.|.:.:..|   |..
 Worm   521 ITLKVITVDVADMSRGGTIVHRPPTASSRHSLVFTPTPSAIYSSTKASSVYRMRFDTHD---AHG 582

Human   797 AEPTLRPDIADA--DSRAATVKQRPTS-RRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSV 858
            .:.....:|.:|  :||.|:|:|||.| |||:.||:.:|..||.:|..:..|..::.........
 Worm   583 VDYYAPNEIRNAYSESRHASVRQRPGSGRRISAAELENLMVRQRVPSVQGSPYQMQYDQESLNGG 647

Human   859 GEDEKLASLLEGRFPRSTSMQDPVREGRGIPPP--PQTAPPPPPAPYYFDSGPPPAFSPPPPPGR 921
            ...:|..|:.:  ..|....::.|....|:...  .|.||......|...|...|..|.
 Worm   648 YSSKKYNSVSD--MKRRKGQRNVVASSAGLNRSTFEQAAPTTSTFEYNCSSRSTPQLSR------ 704

Human   922 AYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPA 986
                 ..||                                         ||..:..:.|.|||
 Worm   705 -----MDSF-----------------------------------------DSFDDEDEMPAPPP- 722

Human   987 ATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGP 1051
                                       ||..:|            .||.:.:.:|:
 Worm   723 ---------------------------ASYISP------------DLQRDSSMQRS--------- 739

Human  1052 GGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPG 1116
               .::|...||.|
 Worm   740 ---EYSRPFRPTSR--------------------------------------------------- 750

Human  1117 ADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSS 1181
                                                                             
 Worm   751 ----------------------------------------------------------------- 750

Human  1182 PLALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPV 1246
                              .::|.|                                       |.
 Worm   751 ------------------PKTPPP---------------------------------------PP 758

Human  1247 PARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPE 1311
            |.:.:..:..:.:::.|             ||.|.|.
 Worm   759 PMQHQNHQNHQYQQQHP-------------SLPRSAS---------------------------- 782

Human  1312 LAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREEL 1376
             .|.|:|....:.|.|.|...||              ..||.:|.....||:..|
 Worm   783 -TPQPIQQQQSSIPPPPPPPPPP--------------HCEPTMVHVEFTPPSTSS---------- 822

Human  1377 ARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAP----ESAADSGVEEADT 1437
                 ||||                   |..:|..:||.|...|||.|    ..||.:.|..:::
 Worm   823 -----VPPP-------------------PPPLPPISSGAPPPPPPPPPGGLMHVAASAPVLMSNS 863

Human  1438 RSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPV 1502
            :..|...|::..........::.:|.|....:.:.|..|   |.::         ||:.|.|
 Worm   864 KGISADALKSVQLKKAEPRETSAASVSNNNNNNNNSTTD---FQMD---------LKNALAK--- 913

Human  1503 TFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPT 1567
                                                     ||||:..|.        .||:
 Worm   914 -----------------------------------------RRSKVAHDV--------DEDE--- 926

Human  1568 VISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGG 1632
               |..||.:.|                ||.:..:::.:...:...::|.::.
 Worm   927 ---ERESRFEGL----------------SLRETVRENVVERGKGIQNIGIVNK------------ 960

Human  1633 GASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRP-FGLT-PPTI----LKSSSLSI 1691
                  :.|| |..:|   :.::|:..|..:         .|| |.|. .|.:    |.|..|..
 Worm   961 ------KDSG-YTSSR---TSLEPSESEEKD---------HRPHFSLDHSPNVQRVTLISQHLED 1006

Human  1692 PHEPKEVRFVVRSVSARSRS------PSPSPLPS-----------PASGPGPGAPGPRR----PF 1735
            .:..|:...|..|.:|.|.|      |....:||           |.||.| .:.|..|    .|
 Worm  1007 NYGQKDNMSVASSSTASSSSTVDLTKPGCFVVPSHVIPPVDYDDDPDSGTG-DSDGEIRCSEISF 1070

Human  1736 QQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERAL 1800
            :.|.:.:||..||..||.|:||.|:...|....|.|..|....:..|.:|||||:.||..||.||
 Worm  1071 EHKKVDVWSVDDVIGWLSSLHLSEYTPAFRSQRINGRCLRQCDRSRFTQLGVTRIAHRQIIESAL 1135

Human  1801 RQL 1803
            |.|
 Worm  1136 RGL 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHANK3	NP_001358973.1	Intramolecular interaction with the ANK repeats. /evidence=ECO:0000250	76..150		27/65 (42%)
		FERM_F0_SHANK3	83..169	CDD:340697	34/84 (40%)
		ANKYR	155..408	CDD:440430	118/253 (47%)
		ANK repeat	223..255	CDD:293786	15/31 (48%)
		ANK 1	223..253		13/29 (45%)
		ANK repeat	257..288	CDD:293786	13/30 (43%)
		ANK 2	257..286		12/28 (43%)
		ANK repeat	290..355	CDD:293786	29/65 (45%)
		ANK 3	290..320		11/30 (37%)
		ANK 4	324..353		14/28 (50%)
		ANK repeat	357..388	CDD:293786	17/30 (57%)
		ANK 5	357..386		17/28 (61%)
		ANK 6	390..420		10/29 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..467		17/59 (29%)
		SH3_Shank3	549..600	CDD:212917	10/51 (20%)
		PDZ_SHANK1_3-like	639..740	CDD:467228	40/100 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..689		9/23 (39%)
		Required for interaction with ABI1. /evidence=ECO:0000250	753..760		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	760..853		25/95 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	871..1021		21/151 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1115..1460		41/348 (12%)
		PRK12323	<1208..>1412	CDD:481241	27/203 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1475..1525		6/49 (12%)
		SH3-binding. /evidence=ECO:0000255	1485..1491		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1546..1584		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1627..1664		6/36 (17%)
		SAM_Shank1,2,3	1739..1804	CDD:188905	28/65 (43%)
shn-1	NP_001379494.1	FERM_F0_SHANK	8..91	CDD:340611	34/84 (40%)
		ANKYR	95..336	CDD:440430	111/241 (46%)
		ANK repeat	145..176	CDD:293786	15/30 (50%)
		ANK repeat	178..209	CDD:293786	13/30 (43%)
		ANK repeat	211..277	CDD:293786	29/65 (45%)
		ANK repeat	279..310	CDD:293786	17/30 (57%)
		PDZ_SHANK1_3-like	429..529	CDD:467228	46/171 (27%)
		SAM_Shank1,2,3	1074..1139	CDD:188905	28/65 (43%)