Protein Alignment SHANK3 and shank3

DIOPT Version :10

• Sequence 1: NP_001358973.1
• Gene: SHANK3 / 85358
• HGNCID: 14294
• Length: 1806
• Species: Homo sapiens
• Sequence 2: XP_017947859.1
• Gene: shank3 / 100488068
• XenbaseID: XB-GENE-1014028
• Length: 1889
• Species: Xenopus tropicalis
• Alignment Length: 2000
• Identity: 1223/2000 - (61%)
• Similarity: 1387/2000 - (69%)
• Gaps: 305/2000 - (15%)

Human     1 MQLSRAAAAAAAAPAEPPE-PLSPAPAPAPAPPGPLPRSAADGAPAGGKGGP------------G 52
            ||..|::.:.|...:..|| |..|.|.|...|.||.....|.|.|....|.|            |
 Frog     1 MQSLRSSPSPAHVVSPVPELPERPGPPPPSPPQGPPRDPGAPGTPCLSGGDPETPESESQSPSRG 65

Human    53 R----RAESPGAPFPGASGPGP------------------------------------------- 70
            |    |..||...:|..||..|
 Frog    66 RDTPTRLRSPNFRYPPDSGREPQGTEKLAQAGDISAQIKERELSSPDRNHHIEDRSIPIRDRYPT 130

Human    71 -----------------------------------------------GPGAGMDGPGASAVVVRV 88
                                                           .||..|:....:||::|:
 Frog   131 FGGKDTPARDRGSPVSDRVSVRSASDLRIRDRELTVRDRDPHGSDRDPPGRRMEETAGNAVIIRI 195

Human    89 GIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYP 153
            |||||||||||||:|.||||.||||:||.|||||:|.||||||||...|||||||||||||:|||
 Frog   196 GIPDLQQTKCLRLNPDAPVWVAKQRILCTLNHSLKDVLNYGLFQPAFNGRAGKFLDEERLLREYP 260

Human   154 PNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNF 218
            |:|.||:||||||||||||.|:|:|||||||||||.||||||:|:||.:.:||.|||::|||||:
 Frog   261 PSLATPVPYLEFRYKRRVYTQSLLDDKQFAKLHTKGNLKKFMEYIQLQNIEKVTRLLERGLDPNY 325

Human   219 HDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGAS 283
            .|||:|||||:||:||:...||:|:|:|||||||||||:||||:|.|...||.|.|.||||||||
 Frog   326 QDPDTGECPLTLASQLEGGADLVKILRNGGAHLDFRTREGLTALHKAVHYRNHAVLMTLLDLGAS 390

Human   284 PDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG 348
            ||||||||||||||||:.|||..||||||.|:|.||..|||||||||||||:|||||||||||||
 Frog   391 PDYKDSRGLTPLYHSAMVGGDPYCCELLLRDYASLGCEDENGWQEIHQACRYGHVQHLEHLLFYG 455

Human   349 ADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 413
            |||.|||||||:|||:||||||||||||||||||::::||:|:|||||||||||||||||:||||
 Frog   456 ADMRAQNASGNSALHLCALYNQESCARVLLFRGASKEIRNFNNQTAFQVAIIAGNFELAEIIKTH 520

Human   414 KDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLL-- 476
            |:||:|||||||||.||||:....||:|||.|||||||.||..:. ...||.||||.||.|||
 Frog   521 KESDIVPFRETPSYTKRRRVVSSVGLSSPRFLQRSASDNNLNSDG-AHYSPVPSLRGLPPQLLSQ 584

Human   477 ------------------------------LQRLQEEKDRDRDADQESNISGPLAGRAGQSKISP 511
                                          |.|.:||:|.|..           ..|.|:.|.||
 Frog   585 GPEVSGIAAVGDSSLASTTSSRSTHSRSPSLHRAREERDIDTH-----------TLRRGRGKSSP 638

Human   512 SGPGGPGPAPGPGPAPPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVL 576
                ||......|          |||||||||||||||.|||||::.|||.|||.|:|||.||||
 Frog   639 ----GPLDVRSTG----------PRGPKRKLYSAVPGRTFIAVKSYEPQGPGEIQLNRGERVKVL 689

Human   577 SIGEGGFWEGTVKGRTGWFPADCVEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYV 641
            ||||||||||:||||:|||||||||||||||.|.|.|||||||||||||||||||||.|||||||
 Frog   690 SIGEGGFWEGSVKGRSGWFPADCVEEVQMRQPDPRQETREDRTKRLFRHYTVGSYDSFTSHSDYV 754

Human   642 IDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLI 706
            |.:|||.||||:.||||||||||||||||||||||||||||||||||||:|||||||||||||||
 Frog   755 IQEKVARLQKRELEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVDGVAWRAGLRTGDFLI 819

Human   707 EVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPE-EDGARRRAPPPPKRAPSTTLTLRSKS 770
            ||||||||||||||||:||||||:.|.||||||:|||| |:..||||||||||||||||||||||
 Frog   820 EVNGVNVVKVGHKQVVSLIRQGGSHLTMKVVSVSRKPESEEAMRRRAPPPPKRAPSTTLTLRSKS 884

Human   771 MTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFER 835
            ||||||||        |:|||:| .|::|:|.||||:|||||||||||||||||||||||||.||
 Frog   885 MTAELEEL--------ERLDEIL-VASDPSLCPDIAEADSRAATVKQRPTSRRITPAEISSLLER 940

Human   836 QGLP-------GPEKLPGSLRKGIPRTKSVGEDEKLA-SLLEGRFPRSTSMQDPVREGRGIPPPP 892
            ||:|       ..||....|..|:.||||||||||.: |..:|||||||||||.:|||.||||||
 Frog   941 QGIPQHAVHHFPNEKHHFQLHHGMSRTKSVGEDEKFSDSFFDGRFPRSTSMQDSLREGPGIPPPP 1005

Human   893 QTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARL-----GAGAAGLYEPGAAL 952
            |.|.||||.|||||:||||.|||||||||.||||.||||||.|||.     |.|:|.|......|
 Frog  1006 QKAAPPPPTPYYFDTGPPPTFSPPPPPGRGYDTVHSSFKPGFEARFHGLQHGMGSAELLSMDRGL 1070

Human   953 GPLPYPERQKRARSMIILQDSA---PESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSA 1014
            .|   |:|||||||||||||::   .|.....||.|:.||||:.|||.|  ..::.|||:|
 Frog  1071 PP---PDRQKRARSMIILQDTSHLPVEPTSIQRPGPSPTPPEKLKRRSR--ATENTYANVG---- 1126

Human  1015 SLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDG 1079
             :|||.||||:||||||||||||||||||||:      .|.|:|:|||:.|.||...::.|....
 Frog  1127 -IFAPMKPQRKKSPLVKQLQVEDAQERAALAM------VGGFSRDPSPSRRSPRQSMMELGTAQH 1184

Human  1080 PGL------AFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPT 1138
            ..|      |..|....::|||:|:|:|||||||||:||:.|..||||||||||:||||||:
 Frog  1185 DPLSSPFATALAGVMKERERRLDEKRKSTVFLSVGALEGTPPSPDLPSLQPSRSVDERLLGS--- 1246

Human  1139 AGRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQA----P 1199
              ||:|||||.|:||.|:    ...|.||||||||||||||:||||||||||||||::||    |
 Frog  1247 --RDVLLPSPGSSLKSLM----YSSSHSTFIHPLTGKPLDPNSPLALALAARERALSAQASSPPP 1305

Human  1200 SRSPTPVHSPDADRPGPLFVDVQARDPERG----SLASPAFSPRSP----AWIPVPARREAEKVP 1256
            .|:||||.||::||..|||:::|.::.|.|    ..|||.:||...    .|: .|.||:.:..|
 Frog  1306 PRTPTPVRSPESDRAPPLFLEIQTKEGEMGMEFEGSASPIYSPSGAQIKGQWV-TPLRRDGDVRP 1369

Human  1257 REERKSP----EDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPM 1317
            .:..:.|    |::|.||||::|||.|:.||||:|||||||.|      .:|:.|      ||..
 Frog  1370 DKSPERPVSKVEERKPMILSIVDTSQQKTAGLIMVHATSNGTE------EKEQEP------PATT 1422

Human  1318 QSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLV 1382
            ....|.:| |....:.|..:.:|...||||||||.| .|..|||||.|||||||||||||:||||
 Frog  1423 DKQKVEQP-PDIEEKAPSSSSSDKTLGQGSSEEEVE-PFGGNLPPAMLSSSDEETREELAKIGLV 1485

Human  1383 PPPEEFANGVLLATP------LAGPG----PSPTTVPS-PASGKPSSEPPPAPESAADSGVEEAD 1436
            |||:.||||||:..|      |..||    ||.....| |.|||||..|.|.||||.||||||.|
 Frog  1486 PPPDAFANGVLVTKPGTPISQLTRPGTLAVPSAKQASSTPPSGKPSDAPHPHPESATDSGVEEVD 1550

Human  1437 TRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGP 1501
            ||||||.|||||||||||||||||||||||.|||:||:|||.||:||||||||||||||.|.||.
 Frog  1551 TRSSSDHHLETTSTISTVSSMSTLSSESGEPTDTYTSYADGQTFILEKPPVPPKPKLKSQLMKGT 1615

Human  1502 VTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLP--GP-ED 1563
            ||||||||||||||||:|||..||          .||||||||||||||||||||.|.  || |.
 Frog  1616 VTFRDPLLKQSSDSELIAQQQLAA----------GRPRYLFQRRSKLWGDPVESRPLSHGGPVEM 1670

Human  1564 DKPTVISELSSRLQQLNKDTRSLGEEP-VGGLGSLLDPAKKSPIAAARLFSSLGELSSISAQRSP 1627
            :||:||.|:|||||.|||||||||||| :.|    :||.||||:.|||||||||||.:|| |||
 Frog  1671 EKPSVIGEISSRLQLLNKDTRSLGEEPSIPG----MDPVKKSPVVAARLFSSLGELHTIS-QRS- 1729

Human  1628 GGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIP 1692
                .|.||:|||..|:|:.|||||||.|:| ||||.|    ||| |.:.|||||||||||||:|
 Frog  1730 ----YGTSYTVRPGSRHPLTRRAPSPVPPSS-ERVEPL----GGA-RSYTLTPPTILKSSSLSVP 1784

Human  1693 HEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAP-GPRRPFQQKPLQLWSKFDVGDWLESIH 1756
            |||||||||||||||||||||||          .|.| .|.|||.||||.||:|:||||||||::
 Frog  1785 HEPKEVRFVVRSVSARSRSPSPS----------SGHPLHPARPFMQKPLSLWNKYDVGDWLESLN 1839

Human  1757 LGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERALRQLDGS 1806
            |.|||.:|:|:||||:|||||||||||||||||||||||||||||||..|
 Frog  1840 LAEHRLKFQDNEIEGSHLPALTKDDFVELGVTRVGHRMNIERALRQLSTS 1889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHANK3	NP_001358973.1	Intramolecular interaction with the ANK repeats. /evidence=ECO:0000250	76..150		54/73 (74%)
		FERM_F0_SHANK3	83..169	CDD:340697	68/85 (80%)
		ANKYR	155..408	CDD:440430	196/252 (78%)
		ANK repeat	223..255	CDD:293786	21/31 (68%)
		ANK 1	223..253		19/29 (66%)
		ANK repeat	257..288	CDD:293786	21/30 (70%)
		ANK 2	257..286		19/28 (68%)
		ANK repeat	290..355	CDD:293786	53/64 (83%)
		ANK 3	290..320		22/29 (76%)
		ANK 4	324..353		27/28 (96%)
		ANK repeat	357..388	CDD:293786	24/30 (80%)
		ANK 5	357..386		24/28 (86%)
		ANK 6	390..420		25/29 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..467		38/59 (64%)
		SH3_Shank3	549..600	CDD:212917	40/50 (80%)
		PDZ_SHANK1_3-like	639..740	CDD:467228	90/100 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..689		23/23 (100%)
		Required for interaction with ABI1. /evidence=ECO:0000250	753..760		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	760..853		65/99 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	871..1021		95/157 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1115..1460		205/371 (55%)
		PRK12323	<1208..>1412	CDD:481241	100/226 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1475..1525		41/49 (84%)
		SH3-binding. /evidence=ECO:0000255	1485..1491		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1546..1584		29/40 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1627..1664		20/36 (56%)
		SAM_Shank1,2,3	1739..1804	CDD:188905	53/64 (83%)
shank3	XP_017947859.1	FERM_F0_SHANK3	190..276	CDD:340697	68/85 (80%)
		ANKYR	263..521	CDD:440430	201/257 (78%)
		ANK repeat	334..362	CDD:293786	18/27 (67%)
		ANK repeat	364..395	CDD:293786	21/30 (70%)
		ANK repeat	397..462	CDD:293786	53/64 (83%)
		ANK repeat	464..495	CDD:293786	24/30 (80%)
		SH3_Shank3	662..713	CDD:212917	40/50 (80%)
		PDZ_SHANK1_3-like	752..852	CDD:467228	89/99 (90%)
		SAM_Shank1,2,3	1822..1887	CDD:188905	53/64 (83%)