DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCN5 and polybromo

DIOPT Version :9

Sequence 1:	NP_011768.1	Gene:	GCN5 / 853167	SGDID:	S000003484	Length:	439	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	91/417 - (21%)
Similarity:	161/417 - (38%)	Gaps:	122/417 - (29%)

- Green bases have known domain annotations that are detailed below.

Yeast    63 GSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGLKNIFQKQ 127
            ||::..|.:         .::..|.:|...:|..:||:..||.:..:.     .:..||    ::
  Fly   276 GSQIYKDAK---------SLKRIFTQRRIELEMGKGKLAKRVKSLSSA-----AIAALK----EE 322

Yeast   128 LPKMPKEYIAR-------LVYDRSHLSMAVIRKPLTVVGGITYRPFDKR-----------EFAEI 174
            :.....|..::       .::|..:.:......|     |:|..|....           |:.|:
  Fly   323 VDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHP-----GVTGPPLGNSLWKLPVRRFHPEYFEL 382

Yeast   175 VFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMG 239
            :...||.::      .|......||. |.|::.     ||.|.:....|:.|.......|
  Fly   383 IKRPISMSQ------IHTKLKKGDYA-NISDLT-----ADLYLMLDNAKKAFPTSHRTHK----- 430

Yeast   240 YIKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLN--NIKP 302
                                  ||.|:|.|..|.|            |...||:..||:  :.:.
  Fly   431 ----------------------DALKMLKLMNAKL------------VEESLEEGSDLDDEDAEE 461

Yeast   303 IDP--MTI--------PGL--------KEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAA 349
            :|.  .|:        ||.        ..|..||. ::.:.:..|...:|||:..:..:|.:...
  Fly   462 MDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPN-NSNSPKSNRIAINAAIKKKILSIQKYLVD 525

Yeast   350 WP---------FLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRM 405
            :.         |::...::..|||||.|:.|:|::|:|..:.:::|..:||.:.|.||:|:|||.
  Fly   526 YSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQ 590

Yeast   406 YNGENTSYYKYANRLEKFFNNKVKEIP 432
            ||.|.::.|:.||.||:..|.|:||.|
  Fly   591 YNEEGSNIYEDANILERALNEKLKEFP 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCN5	NP_011768.1	COG5076	77..439	CDD:227408	88/403 (22%)
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	4/26 (15%)
		Bromo_polybromo_III	335..443	CDD:99951	26/151 (17%)
		Bromo_polybromo_IV	512..613	CDD:99949	32/100 (32%)
		Bromo_polybromo_V	641..733	CDD:99946
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900