DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCN5 and Gcn5

DIOPT Version :9

Sequence 1:	NP_011768.1	Gene:	GCN5 / 853167	SGDID:	S000003484	Length:	439	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	170/431 - (39%)
Similarity:	243/431 - (56%)	Gaps:	41/431 - (9%)

- Green bases have known domain annotations that are detailed below.

Yeast    33 IQPEQAET--NKQEGTDKENKGKFEKETERIGGSEVVTDVEKGIVKFEFDGV---------EYTF 86
            |.|..|..  ||:....:....:.:||......||.:.|:...:|......|         |..|
  Fly   387 IGPSAASIGGNKRTSVGEPLHKRIKKEPTDRPSSENLDDLPADVVMRAMKSVSESKTTNKAEILF 451

Yeast    87 -----KERPSVVEENEGKIEFRVVNNDNT----KENMMVLTGLKNIFQKQLPKMPKEYIARLVYD 142
                 ::.....||.:..|||.||.|..|    |:.::.|.||:.:|..|||:||:|||::||:|
  Fly   452 PVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFD 516

Yeast   143 RSHLSMAVIR--KPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSN 205
            ..|.::|:|:  :|   :|||.:|||..:.|.||||||::.:|||:|||.||||||||| .....
  Fly   517 TKHKTLALIKENQP---IGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDY-SIQRG 577

Yeast   206 IKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLMQCSMLPRIRYLDAGKILLLQ 270
            ||:.||:||..||||||||||:|:|.|.:.::.||||:|:..|||.|.:.|.|.......::..|
  Fly   578 IKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQ 642

Yeast   271 EAALRRKIRTISKSH----IVRPGLEQFKDLNNIKPIDPMTIPGLKEAGWTPE-MDALAQRPKRG 330
            ...|:   ..|::.|    .|||||..||:...:.|::  :||||:|.||.|: ..|.:.||...
  Fly   643 SEILK---ELIAQRHNEVQKVRPGLTCFKEGLPVIPVE--SIPGLREIGWKPQNRPARSSRPLEE 702

Yeast   331 PHD-----AAIQNILTELQNHAAAWPFLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKME 390
            ..|     .:..::|..::.|..|||||:||...|||||||.||.||||.||..:|:...||...
  Fly   703 STDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRR 767

Yeast   391 DFIYDARLVFNNCRMYNGENTSYYKYANRLEKFFNNKVKEI 431
            .|:.|...:|:|||.||..:|.||:.||.||::|..|::|:
  Fly   768 LFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMREL 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCN5	NP_011768.1	COG5076	77..439	CDD:227408	159/385 (41%)
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997
		COG5076	451..807	CDD:227408	156/364 (43%)
		Acetyltransf_1	526..598	CDD:278980	43/75 (57%)
		Bromo_gcn5_like	708..808	CDD:99941	44/99 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346582
Domainoid	1	1.000	93	1.000	Domainoid score	I1708
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		oto99642
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	LDO	PTHR45750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R479
SonicParanoid	1	1.000	-	-		X1691
TreeFam	1	0.960	-	-
	12	11.730