DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KSS1 and rl

DIOPT Version :9

Sequence 1:	NP_011554.3	Gene:	KSS1 / 852931	SGDID:	S000003272	Length:	368	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	180/365 - (49%)
Similarity:	237/365 - (64%)	Gaps:	30/365 - (8%)

- Green bases have known domain annotations that are detailed below.

Yeast     7 FDIPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHEN 71
            |::..:|..:..|||||||.|.||....:..:||||||.||..:.:..||:|||.:|..| :|||
  Fly    32 FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRF-KHEN 95

Yeast    72 IISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHS 136
            ||.|.|.:|..|||::..||:|:.||||||.|::..|.     ||:||:.||.|||||.||.|||
  Fly    96 IIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQR-----LSNDHICYFLYQILRGLKYIHS 155

Yeast   137 AQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQ 201
            |.|:|||:||||||||..||||:|||||||.    :|......||:||||||||||||||||..:
  Fly   156 ANVLHRDLKPSNLLLNKTCDLKICDFGLARI----ADPEHDHTGFLTEYVATRWYRAPEIMLNSK 216

Yeast   202 EYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLP 266
            .||.::||||.|||||||:|.:|:|||:.|..||..||.|||:||.:|...|.:::|:.|:.:||
  Fly   217 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLP 281

Yeast   267 MRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPSDEP--EYP-PL 328
            .:|.:||..::...|..  .:|||.|||.|||.|||...|||.||||..|:||.|||  |.| .:
  Fly   282 FKPNVPWAKLFPNADAL--ALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRI 344

Yeast   329 NLDDEFWKLDNKIMRPEEEEEVPIEMLKDMLYDELMKTME 368
            |:               |.:::..:.||.::::|.:|..|
  Fly   345 NM---------------ENDDISRDALKSLIFEETLKFKE 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSS1	NP_011554.3	PKc_like	7..365	CDD:419665	178/360 (49%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	178/360 (49%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	162/299 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	323	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37670
Inparanoid	1	1.050	346	1.000	Inparanoid score	I402
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		otm46891
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1382
SonicParanoid	1	1.000	-	-		X259
TreeFam	1	0.960	-	-
	13	12.850