DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F2 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	110/417 - (26%)
Similarity:	199/417 - (47%)	Gaps:	41/417 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   124 FYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHF----NILKPYMKIFNESVNIMHAKWQLLASE 184
            ||:.::..|...|....|.||...|..|||.|..    |:....:|:..|...:..:|   .|::
  Fly   105 FYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSK---TAAD 166

Human   185 GSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP-SEYIAAILELSALVSKRHHEILLHID-FLY 247
            ....|::.:.::..|.|.:..|.|..:.:....| :|:::  :...|:...|:..:|   | ||:
  Fly   167 RGQVLEVVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVS--IGKRAITEHRYGNML---DIFLF 226

Human   248 YLTPDGQRFRRACRL--VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLL------- 303
            ......:|.|....:  ..||...:::|.        :|  .:.:.|.|..||:|.|:
  Fly   227 GFPKLSRRLRLKLNIQEAEDFYTKIVRET--------ID--YRLRTKEKRNDFMDSLIEMYKNEQ 281

Human   304 LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPK 368
            ....|||  |:..::.|:|..|...|.:|:::.:.:.||.||::.:.|::.|:|:..:. .:..|
  Fly   282 SGNSEDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVF-GKHNK 343

Human   369 EIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGR-VIPKGIICLISVFGTHHNPA 432
            |..::.:..:.:|...:.|:||.:|.:..::|....|....|.: .|.||.|.:|...|.|::|.
  Fly   344 EFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPD 408

Human   433 VWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL--LRFRVLPDH 495
            ::|:||::.|.||..|.|..|....::||..|||||||..|.|.:..|.||..:  .:|.|.|:.
  Fly   409 IYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPET 473

Human   496 TEPRR--KPELVLRAEGGLWLRVEPLS 520
            ..|.:  ...:::.||.|:.|:||.|:
  Fly   474 QIPMKIVVKNILISAENGIHLKVEKLA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	106/410 (26%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	103/393 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2076
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840