DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F2 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	161/517 - (31%)
Similarity:	243/517 - (47%)	Gaps:	81/517 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    19 WLLLLLVGASWLL------AHVLAWTYAFYDNCRRLRCFPQPP--------RRNWFWG------- 62
            ||:|.|....:.|      .|:|    :|:  .:|:|.....|        :....:|
  Fly     5 WLILALSALLYWLHRANKDYHIL----SFF--TKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYG 63

Human    63 --HQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFY 125
              |.|:.|.:.|..:.:......|..|..::        ::...|...:|:|....|.  ....|
  Fly    64 RDHAGVFNYSRERAKEMGTSYIEYVFGKAIY--------NIIDADSAENVLNHPNLIT--KGLVY 118

Human   126 SFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIF-NESVNIMHAKWQLLASEGSACL 189
            :||.|:|..|||.|.|.||...|:||||.||||||..:.:|| .||...      ||..||.
  Fly   119 NFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKF------LLQFEGQ--- 174

Human   190 DMFEHISLMTLDSLQKCVFSFDSHCQ-----------EKPSEYIAAILELSALVSKRHHEILLHI 243
               :.:::...|.:.:  |:.:|.|:           ||...|.....::.....:|....||..
  Fly   175 ---DEVTITLHDVIPR--FTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWG 234

Human   244 DFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTL-------PSQGVDDFLQAKAKSKTLDFIDV 301
            |.|:.:.. .:.|..|..:||.|:..:|.:||..|       .|...||...:|.:...||
  Fly   235 DKLFEMFA-AKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLD---- 294

Human   302 LLLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDR 365
            .|:..::||  |.|. .|..|.||.||||:|||:.||.:.|.:::.:|:.||.|.||:||.:.|
  Fly   295 TLIYAEKDG--LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDD- 356

Human   366 EPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHN 430
            :...::...|..|.:|...|||:.||.|.||::.|...|:..|.:|.::|||....|.||..|.|
  Fly   357 DLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRN 421

Human   431 PAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVL 492
            ...|..||.:.|.||.|||:::|...|::|||||.|||||:.:||.|||.::.:.|.:|:||
  Fly   422 AKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	11/51 (22%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	151/478 (32%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	150/462 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850