DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F2 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	158/550 - (28%)
Similarity:	267/550 - (48%)	Gaps:	79/550 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    19 WLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWG----------HQGMVNPTEEG 73
            |::|    .::|...:...||......||.|..      |.|.|          ||....|||
  Fly     2 WIVL----CAFLALPLFLVTYFELGLLRRKRML------NKFQGPSMLPLVGNAHQMGNTPTE-- 54

Human    74 MRVLTQLVATYPQ----GFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
              :|.:....:.:    .|:.|:|..|.:: :.:|..:..::::...|:..|  .|....||||.
  Fly    55 --ILNRFFGWWHEYGKDNFRYWIGYYSNIM-VTNPKYMEFILSSQTLISKSD--VYDLTHPWLGL 114

Human   135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMT 199
            |||.|.|.||.:||:|:|||||||||:.:.::.||:......:.:.:| :|....|..|....:|
  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVA-DGGNIFDFQEEAHYLT 178

Human   200 LDSLQKCVFSFDSHCQE-KPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLV 263
            ||.:.........:..| :.|..:.|..:::..:..|.........:|::..|:...:.:..:.:
  Fly   179 LDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTL 243

Human   264 HDFTDAVIQER---RRTLPSQGV--DDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEAD 323
            .|||:.:|.:|   |::....|:  |:|     ..|.:.|:|.||.|| .||:.|:.:::..|..
  Fly   244 QDFTNEIIAKRIEVRKSGLEVGIKADEF-----SRKKMAFLDTLLSSK-VDGRPLTSQELYEEVS 302

Human   324 TFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL-KDREPKEIEWDDLAHLPFLTMCMKE 387
            ||||||||||.||:.:.:|.|::||:.||:...|..::: .....::..:.:::.:..|.:.:||
  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367

Human   388 SLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKE 452
            :.||:|.||.|.|...:|.|: ||.::|||....:.:....:|..|:.||..:.|.|||.|   :
  Fly   368 AQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDRE---K 428

Human   453 RSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP------------------------ 493
            ..|..::||||||||||||.||:.|:|.|::..:..|.|||
  Fly   429 PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKK 493

Human   494 -----DHT-EPRRKPELVLRAEGGLWLRVE 517
                 :|. :|.....:.|::|.||.||::
  Fly   494 SRDAHNHKYDPILSASMTLKSENGLHLRMK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	8/37 (22%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	148/513 (29%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	138/452 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650