DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F2 and Cyp316a1

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	104/408 - (25%)
Similarity:	182/408 - (44%)	Gaps:	39/408 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   125 YSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACL 189
            |..::.||..|:|:...::|.:...:::..|....|:..:.:.......:..|  |.........
  Fly   101 YELMKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQK--LAKQADQKVF 163

Human   190 DMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDG 253
            |::..:|.:.||.:..      :.|..||| ||...:.:||.:..||...:.....|.|:|:...
  Fly   164 DIWYTVSPIVLDLMVM------TTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPF 222

Human   254 QRFRRACRLVHDFTD------AVIQERRRTLPSQGVDDF-LQAKAKSKTLDFIDVLLLSKDEDGK 311
            .| :|..||:....|      |:.|.:.:.....|:|.: |:..........:::||.|||   .
  Fly   223 MR-KRQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEILLESKD---P 283

Human   312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
            :|:.|:|..|.:|..:.|:...:..|.:.|..:|::|..|::|..|    |...:.|:..| ||.
  Fly   284 QLTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDE----LNLAQIKDQGW-DLE 343

Human   377 HLPFLTMCMKESLRLHPPVPVISRHVTQDI-----VLPDGRVIPKGIICLISVFGTHHNPAVWPD 436
            .|.:|...:.|::||:||..::.|.:.:|.     ::.|.. :|.|....|:::....|...:|.
  Fly   344 KLNYLDAVLHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAE-LPCGSEIYINLYELQRNEVRYPK 407

Human   437 PEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRR 500
            ...:|..|| |       ||...:.:|.|||.|..:.|:|..:|.:||..|..|.|||...|.|.
  Fly   408 ANHFDAQRFLD-------SPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRL 465

Human   501 KPELVLRAEGGLWLRVEP 518
            ...|||.:..|..|.::|
  Fly   466 DLRLVLGSSNGFQLALKP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	102/403 (25%)
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	98/389 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820