DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F2 and Cyp9c1

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	105/444 - (23%)
Similarity:	190/444 - (42%)	Gaps:	72/444 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    97 PLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLG--DGL---------LLSAGD-KWSRHRR 149
            ||..|..|::||.|         ..|.|.:|.....|  :|.         |||..| :|.:.|.
  Fly    81 PLYYLSDPELIRQV---------GIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRS 136

Human   150 MLTPAFHFNILKPYMKIFN----ESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSF 210
            .|||.|....::...::.:    |:|:.:    |.....|::.|::.:..:..|.|.:....|..
  Fly   137 TLTPTFTSLKIRQMFELIHFCNVEAVDFV----QRQLDAGTSELELKDFFTRYTNDVIATAAFGI 197

Human   211 DSHCQEKP-SEYIAAILELSALVSKRHHEILLHI-------------------DFLYYLTPDGQR 255
            ..:..:.| :|:.:....:|........:::|:|                   |:...|.....:
  Fly   198 QVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFKKLVFGAMK 262

Human   256 FRRACRLVH-DFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIR 319
            :|:...:|. |....:::.:|:....|      :..|:|           :..:|..:.:|:|:.
  Fly   263 YRKEQSIVRPDMIHLLMEAQRQFKAEQ------EGSAES-----------AAQQDKAEFNDDDLL 310

Human   320 AEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMC 384
            |:...|...|.:|.|:.||:..|.|..:||.||:...|:..:.:....|.:::|.|..:.:|...
  Fly   311 AQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCV 375

Human   385 MKESLRLHPPVPVISRHVTQDIVLPD--GRVI---PKGIICLISVFGTHHNPAVWPDPEVYDPFR 444
            :.||||..||..::.|....|..|.|  |.|:   .:..:..|:|...||:|..:|:||.:.|.|
  Fly   376 VSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPER 440

Human   445 FDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498
            ||.|:..|.....::||..|.|:|||...|:.|:|.::...:||:.:.|....|
  Fly   441 FDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTP 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	105/444 (24%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	105/444 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900