DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F2 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	151/519 - (29%)
Similarity:	259/519 - (49%)	Gaps:	57/519 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    20 LLLLLVGASWLLAHVLAWTYAFYDNCR----------RLRCFPQPPRRNWFWGHQGMVNPTEEGM 74
            |:||::..|         .|.||....          ||...|..|    |.|:..:|...:...
  Fly    19 LILLVISLS---------IYTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDKDLMR 70

Human    75 RVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLS 139
            |...:....|....::|: .:.|..::..|:.::.::  |:.......|||..:..:|||||:.|
  Fly    71 RCAGKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVIL--SSKKHTNKVFFYRLMHNFLGDGLITS 132

Human   140 AGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSAC-LDMFEHISLMTLDSL 203
            :|.|||.|||::.||||.|:|:.::..|   |:...:.::.|.:|.... :::.::::...||.|
  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTEINIAKYVNNCVLDIL 194

Human   204 QKCVFSFDSHCQEKPSEYIAAILELS------ALVSKRHHEILLHIDFLYYLTPDGQRFRRACRL 262
            .:.|.....    |......|::|.|      .::..|..:..|.:|.:|:.|..........:.
  Fly   195 NEAVLGVPI----KKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKR 255

Human   263 VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMF 327
            ::|||..:||.||:      :.:.....::.|.|  :| .::...|..:..::|||..||.|||.
  Fly   256 LNDFTRKMIQRRRQ------IQNNNNGNSERKCL--LD-HMIEISESNRDFTEEDIVNEACTFML 311

Human   328 EGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD--REPKEIEWDDLAHLPFLTMCMKESLR 390
            .|.|:..:.:::.|:.|.::||.|:||..|:..:.:|  |.|   ...||..:.::.||:||:||
  Fly   312 AGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALR 373

Human   391 LHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSP 455
            |:|.||:|:|.:.:::.|.. ..:|.|....|..:.||....::||||.:.|.||.|||.:.|.|
  Fly   374 LYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHP 437

Human   456 LAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP--DHTEPRRKPELVLRAEGGLWLRVE 517
            .||:|||||||.|||..||:.|:|.:::..|..:::||  ..|.......:.|||.||||:|::
  Fly   438 YAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	11/46 (24%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	141/473 (30%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	131/451 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750