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Protein Alignment CYP4F2 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	129/505 - (25%)
Similarity:	223/505 - (44%)	Gaps:	64/505 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    56 RRNWFWGHQG----MVNPTEEGM------RVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSV 110
            ||:.:|..:|    :.:|....|      |.:..:...|...:|..:.|.:..........:.:.
  Fly    21 RRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFAGFYFFFTRSAVITD 85

Human   111 INASAAIAPKD-------KFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHF----NILKPYM 164
            :.....:..||       ..||:.::..|...|....|.||...|..|||.|..    |:....:
  Fly    86 LELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIV 150

Human   165 KIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP-SEYIAAILEL 228
            |:..|...|..||  ....||.. |::.:.::..|.|.:..|.|..:.:..:.| :|::.  :..
  Fly   151 KVGEEMEKIFSAK--TTTGEGQV-LEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVT--IGK 210

Human   229 SALVSKRHHEILLHIDFLYYLTPDGQRFRRACRL------VHDFTDAVIQERRRTLPSQGVDDFL 287
            .|::.:|:..:|   |||.:..|   :..|..||      |.||..:::   |.|:      |:
  Fly   211 RAIIERRYGGLL---DFLIFGFP---KLSRRLRLKLNVQDVEDFYTSIV---RNTI------DY- 259

Human   288 QAKAKSKTLDFIDVLL-------LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLA 345
            :.:...|..||:|.|:       ....|||  ||..:|.|:|..|...|.:|:::.:.:.||.||
  Fly   260 RLRTNEKRHDFMDSLIEMYEKEQAGNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELA 322

Human   346 KHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPD 410
            ...:.|::.|.|:..:| .:...|..::.:..:.:|...:.|:||.:|.:..::|....|....|
  Fly   323 LDQDIQDQLRAEINNVL-SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPED 386

Human   411 GR-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFA 474
            .: .|.||...:|...|.|::|.::|:||.:.|.||..|.|..|....::||..|||||||..|.
  Fly   387 PKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFG 451

Human   475 MAEMKVVLALTL--LRFRVLPDHTEPRR--KPELVLRAEGGLWLRVEPLS 520
            :.:..|.||..:  .:|.|..:...|.:  ...::|.||.|:.|:||.||
  Fly   452 LMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLS 501

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.