Protein Alignment CYP4F2 and Cyp9h1

DIOPT Version :10

• Sequence 1: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 132/559 - (23%)
• Similarity: 232/559 - (41%)
• Gaps: 112/559 - (20%)

Human    20 LLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEE---GMRVLTQLV 81
            |.|.::    ||..:..|:.|.||.........:.|     |...|.: |.:.   ||.||.:::
  Fly     8 LALFII----LLVLLYKWSVAKYDVFSERGVSHEKP-----WPLIGNI-PLKAMIGGMPVLKKMI 62

Human    82 ATYPQGFKVWMGPISPLLSL-------CHPDIIRSVINASAAIAPKDKF------FYSFLEPWLG 133
            ..:.   |....|:..:.:|       ..|::|:.:     .|...|.|      ..:..|..|.
  Fly    63 ELHT---KHTGSPVYGIYALRDAVFFVRDPELIKLI-----GIKEFDHFVNHNSMHNNIQESILS 119

Human   134 DGLLLSAGDKWSRHRRMLTPAF---HFNILKPYMKIFNESVNIMHAKWQL-LASEGSACLDMFEH 194
            ..|:.....:|...|.:|||||   ...|:...::..:|. .::|.:.|| |:.:.|..|:|.::
  Fly   120 KSLISLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEE-GVIHIQEQLELSQDASIELEMKDY 183

Human   195 ISLMTLDSLQKCVFSFD-SHCQEKPSEY--------------------------IAAILELSALV 232
            .:....|.:....|... :..:.|.:|:                          :..:|.:..|.
  Fly   184 FTRFANDVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLD 248

Human   233 SKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLD 297
            :|       :||:...|.....|:|              ||.:...|     |.:....::|...
  Fly   249 TK-------NIDYFSSLVTAAMRYR--------------QEHKVVRP-----DMIHLLMEAKQQR 287

Human   298 FIDVLLLSKDE-DGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
            ..|:...|||| ...:.:.:|:.|:...|.|.|.:..:|.|.::.:.|..:|..|:|..:|:..:
  Fly   288 LADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISV 352

Human   362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPD--GRVI---PKGIICL 421
            .::.:.:.:.:|.|..:.:|.|.:.|:||..||.....|...|||.|.|  |:.:   .||.:..
  Fly   353 HEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQ 417

Human   422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALT 485
            |.:|..||:|..:.|||.::|.|| |...::.|   .::||..|||||||...|:.|:|.::...
  Fly   418 IPIFSLHHDPENFEDPEFFNPERFADGHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQL 479

Human   486 LLRFRVLPDHTEPRRKPELV-------LRAEGGLWLRVE 517
            ||.|::||   ..|...:|:       |:.:.|.||:.|
  Fly   480 LLNFKLLP---AKRTSRDLLNDIRGHGLKPKNGFWLKFE 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	117/498 (23%)
Cyp9h1	NP_610820.1	CYP6-like	69..511	CDD:410679	112/479 (23%)