Protein Alignment CYP4F2 and Cyp4p3

DIOPT Version :9

• Sequence 1: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_610473.1
• Gene: Cyp4p3 / 35948
• FlyBaseID: FBgn0033397
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 169/536 - (31%)
• Similarity: 257/536 - (47%)
• Gaps: 71/536 - (13%)

Human    20 LLLLLVGASWLLAHVLAWTYAF-YDNC------RRLRC-FPQPPR------------RNWF--WG 62
            |:|.||||..:|   :.|.|.. .|.|      :|:|. ..|.|.            .|.|  :|
  Fly     2 LILWLVGAFIVL---IQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYG 63

Human    63 --HQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFY 125
              |.|:...:.:..:.|.:..|.|..|..::        ::...|....|:|....|  .....|
  Fly    64 KDHSGVFEHSRDCAKKLGKSYAEYAMGTAIY--------NVIDADSAERVLNDPNLI--NKGTIY 118

Human   126 SFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIF-NESVNIMHAKWQLLASEGSACL 189
            .||.|:|..|||.|.|.||...|:||:|.||||||..:.:|| .||:..:    :.......|.:
  Fly   119 DFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEAII 179

Human   190 DMFEHISLMTLDSLQKCVFSFD-SHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDG 253
            .:.|.|...||:|:.:...... ....||...|.....::.....:|....||..|.|:.:..:
  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE- 243

Human   254 QRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLD-----------FIDVLLLSKD 307
            :.:..|..:||.|:..:|.:||..|     :|.:.::..::|.:           .:|.|:|: :
  Fly   244 KDYASALDVVHGFSSEIIAKRRDQL-----NDEIDSRGNTQTAEDELFTSKKRFAMLDTLILA-E 302

Human   308 EDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
            :||  |.|. .|..|.||.||||:|||:.||.:.|.:::.:||.||:|.||:|..:.| |...:.
  Fly   303 KDG--LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDD-ELNILN 364

Human   372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPD 436
            ...|..|..|...:||::||.|.||.:.|..|::..|.:|.::|||....:.||..|.||..|..
  Fly   365 IGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDS 429

Human   437 PEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRK 501
            ||.:.|.||.|||.:.|...|:||||||.||||||.|||.|||.::...|.:|::||: .:|:
  Fly   430 PEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPE-IDPK-- 491

Human   502 PELVLRAEGGLWLRVE 517
               .:..:.||.||.:
  Fly   492 ---TIVFQTGLTLRTK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	15/56 (27%)
		p450	52..515	CDD:365848	154/492 (31%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	154/481 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850