Protein Alignment CYP4F2 and Cyp4e2

DIOPT Version :9

• Sequence 1: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_001286196.1
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 166/557 - (29%)
• Similarity: 268/557 - (48%)
• Gaps: 82/557 - (14%)

Human     8 WLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQ--PPRRNWFWG--HQGMVN 68
            |..|:...|.|.||:               .|......||.|...:  .||.....|  ||...|
  Fly     2 WFVLYIFLALPLLLV---------------AYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKN 51

Human    69 PTEEGMRVLTQLVATYPQ----GFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLE 129
            |:|    :|..:.:.:.|    .|..|:|..|.:| :.....:..::::...|...|  .|....
  Fly    52 PSE----ILDTVFSWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD--IYQLTH 109

Human   130 PWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
            ||||.|||.|.|.||.:||:|:|||||||||:.:.::.||:..  |.|.|   ..:.|....|..
  Fly   110 PWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQ 171

Human   193 EHISLMTLDSLQKCVFSFDSHCQE-KPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRF 256
            |....:|||.:.........:..| :.|..:.|..::...::.|....|...:.||.|.||...:
  Fly   172 EQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAY 236

Human   257 RRACRLVHDFTDAVIQERRRTLPSQGV-----DDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDE 316
            .|..:.:.|||:.:|.:|.....|..|     |:|.:     |.:.|:|. |||...||:.|:.:
  Fly   237 SRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDT-LLSSTIDGRPLNSK 295

Human   317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDRE-PKEIEWDDLAHLPF 380
            ::..|..||||||||||.||:|:.:|.|::|.:.|.:..:|.:|::.:.| .::..:.:::.:.:
  Fly   296 ELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKY 360

Human   381 LTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445
            |.:.:||:.|::|.||.|.|...:|.|: ||.::|||....:.:....:|..|:.||..:.|.||
  Fly   361 LDLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERF 424

Human   446 DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV------------------- 491
            :   :::..|..::||||||||||||.||:.|:|.|::..:..|.|
  Fly   425 E---LEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIG 486

Human   492 LPDHTEPRRKP-----------ELVLRAEGGLWLRVE 517
            |||....:|.|           .|.|::|.||::|::
  Fly   487 LPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	11/50 (22%)
		p450	52..515	CDD:365848	155/509 (30%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	145/453 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650