DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F2 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	103/467 - (22%)
Similarity:	180/467 - (38%)	Gaps:	86/467 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    96 SPLLSLCHPDIIRSVI--------NASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLT 152
            :|:::|..|::|:.|.        |....|...|:.|        .|.|.:....:|...|..||
  Fly    79 TPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLF--------NDMLSVMRDQRWKHMRNTLT 135

Human   153 PAFHFNILKPYMKIFNES----VNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSH 213
            |.|....::....:.|||    :..:.:..:.|.......:||....:.::.|.:....|....:
  Fly   136 PVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTAFGLKVN 200

Human   214 CQEKPSEYIAAI--------------LELSALVSKRHHEILL------HIDFLYYLTPDGQRFRR 258
            ..:.|......|              ..||.||.|....:.|      .:|:...|..:..::|
  Fly   201 SYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIFDSAKVDYFARLVVEAMQYR- 264

Human   259 ACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEAD 323
                         ::...|.|                 |.|.:|:.:|:|...|.:|::|.|:..
  Fly   265 -------------EKHNITRP-----------------DMIQLLMEAKNESEDKWTDDEIVAQCF 299

Human   324 TFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388
            .|.|...:..::.:....|.|..:|:.|||..:|:.|..|......:.:|.:..:.::.|.:.||
  Fly   300 IFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISES 364

Human   389 LRLHPPVPVISRHVTQDIVL--PDGRVI---PKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPE 448
            ||.........|..::|..|  .||..:   ..|....|.:.|.|.:...:|:|..:||.||..|
  Fly   365 LRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEE 429

Human   449 NIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEG--- 510
            ...:..|..::||..|||||||..:|:.::|.:|...||.:::   ...||...:|...|.|
  Fly   430 RKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKI---EASPRTIKDLWGSASGFNF 491

Human   511 ----GLWLRVEP 518
                |.|:.:.|
  Fly   492 TPRSGFWMHLVP 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	102/462 (22%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	96/440 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900