DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F2 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	165/545 - (30%)
Similarity:	268/545 - (49%)	Gaps:	85/545 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    19 WLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEE----------- 72
            |:||.:.    :|...|.|     ||.|:                |..||..|:
  Fly     2 WILLGIA----VLIMTLVW-----DNSRK----------------QWRVNTFEKSRILGPFTIPI 41

Human    73 ---GMRVLT-----------QLVATYPQGFKVWMGPISPLLSLC---HPDI--IRSVINASAAIA 118
               |::.||           .....|.:.|::|      :|..|   ..|:  ..|::::|..:
  Fly    42 VGNGLQALTLRPENFIQRFGDYFNKYGKTFRLW------ILGECLIYTKDLKYFESILSSSTLL- 99

Human   119 PKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLAS 183
             |....|.||..:||||||||.|:||:..|::|.|||||..|:.:::|.:.:..||..|.:..|
  Fly   100 -KKAHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA- 162

Human   184 EGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLY 247
            :|..|:|:|:.:||..||...:.......:.|.:|: .|..|:..:..:.|||...:.:..::|:
  Fly   163 DGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLF 227

Human   248 YLTPD--GQRFRRACRLVHDFTDAVIQERRRTLP---SQGV-------DDFLQAKAKSKTLDFID 300
            .|...  .:|.::...::.||||.||:|||..|.   :.|.       ||.:..|||...||
  Fly   228 PLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD--- 289

Human   301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDR 365
             :||....|.|.|||.|||.|.|.|:|.|.|||.||:|..|:.:::||:.||...:|:..:|...
  Fly   290 -ILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPD 353

Human   366 EPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFGTHH 429
            ....:....|..|.:|...:||::|||||||::.|::.:|:.:  |.: ||.....|:..:..:.
  Fly   354 PDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYR 416

Human   430 NPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP 493
            :|..:|||.|:.|.|: |.:......|||:||||:||:|||||.||..:||.:::..:..:.:||
  Fly   417 DPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481

Human   494 DHTEPRRKPELVLRAEGGLWLRVEP 518
            ...:.:.....:|.:..|..:.::|
  Fly   482 LGADLKATYTFILSSSTGNNVGLKP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	9/37 (24%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	155/507 (31%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	148/461 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750