DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F2 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	150/552 - (27%)
Similarity:	266/552 - (48%)	Gaps:	54/552 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     2 SQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFY-DNCRRLRC---FPQPPRRNWF-W 61
            |..|.:.||..|      :|..|||.  |:|..|   |.:: .|.|..|.   .|.||..... .
  Fly    15 SSSSTTVLGFSP------MLTTLVGT--LVAMAL---YEYWRRNSREYRMVANIPSPPELPILGQ 68

Human    62 GHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYS 126
            .|........|.:.|....:..|.:..|.|:|.:. |:.|.:|..|..:::....:...::  |.
  Fly    69 AHVAAGLSNAEILAVGLGYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE--YR 130

Human   127 FLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDM 191
            :.:||.|||||:|.|..|..||:|:.|.||.:|||.::..|.:....:.|:..|   |.....|:
  Fly   131 YFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGL---EAGKSFDV 192

Human   192 FEHISLMTLDSLQKCVFSFDSHCQ-EKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQR 255
            .:::|..|:|.|...........: .|..||..|::::..::.||..::|..:|.:|..|...::
  Fly   193 HDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREK 257

Human   256 FRRACRLVHDFTDAVIQERRRTLPSQG-------------------------VDDFLQAKAKSK- 294
            ..|...::...|..|:::|:.....:.                         :||..:....:|
  Fly   258 GDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKR 322

Human   295 TLDFIDVLL-LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEV 358
            .|..:|.:: ::|:.| .:.:::||..|.:|.||||||||::|.|:.|..:..|.:.|.:...|.
  Fly   323 RLALLDAMVEMAKNPD-IEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQ 386

Human   359 QELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG-RVIPKGIICLI 422
            :.:..|...::..:.|...:.:|...:.|:|||:||||:|:|.:..|:.|..| ..:|||...::
  Fly   387 KAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIV 451

Human   423 SVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLL 487
            ..:..|..|.::|:|..:||..|.||.:..|...:|||||||||:|:|:.:||.::||:|:..:.
  Fly   452 LQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVR 516

Human   488 RFRVLPDHTEP--RRKPELVLRAEGGLWLRVE 517
            .:.|....||.  :.:.:::|:.|.|..:.:|
  Fly   517 NYIVHSTDTEADFKLQADIILKLENGFNVSLE 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	18/56 (32%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	133/494 (27%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	127/466 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920