Protein Alignment LSG1 and Ns3

DIOPT Version :10

• Sequence 1: NP_011416.3
• Gene: LSG1 / 852779
• SGDID: S000003067
• Length: 640
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Alignment Length: 679
• Identity: 250/679 - (36%)
• Similarity: 358/679 - (52%)
• Gaps: 134/679 - (19%)

Yeast    21 RKNKNKL-ELGRAIKYARQKENAIEYLPDGEMRFTTDKHEA-NW--VKLRSVTQESALDEFLSTA 81
            :|||... .|||.:...|........:.:..|..||:..:. :|  :.|.|||:||:...||.||
  Fly     3 KKNKGGAPNLGRQLIKDRFGHTQRRKVDNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAFLRTA 67

Yeast    82 ALADKDFTADRHSNVKIIRMDSGNDSATSQGFSMTNEQRGNLNAKQRALAKDLIVPRRPEWNEGM 146
            .||..:|.|:: .|:..:     |........|.|.|||  ::.|.......|.:||||:|.:..
  Fly    68 ELAGTEFQAEK-LNITFV-----NPKQRVGLLSKTQEQR--MHQKHDEHRDQLKIPRRPKWTKET 124

Yeast   147 SKFQLDRQEKEAFLEWRRKLAHLQESNEDLLLTPFERNIEVWKQLWRVVERSDLVVQIVDARNPL 211
            |..:|.|.|.||||:|||.||.||| :|::|:||:|:|:|.|:||||||||||:|||||||||||
  Fly   125 SAEELVRAENEAFLDWRRDLALLQE-DEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPL 188

Yeast   212 LFRSVDLERYVKESDDRKANLLLVNKADLLTKKQRIAWAKYFISKNISFTFYSALRANQLLEKQK 276
            ||||.||||||||.:..|.|::||||:||||::||..||:||.|:.|...||||....:.|:::.
  Fly   189 LFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREA 253

Yeast   277 EMGEDYREQDFEEADKEGFDADEKVMEKVKILSIDQLEELF---------LSKAPNEPLLPPLPG 332
            |...|    .|.|..:.     .:.:|::| .|:|.:|:..         :.:..|:. ||.|||
  Fly   254 EECLD----SFPEVQQL-----RRAVEEIK-QSLDSVEDALNVIEQKYKTIPETQNDE-LPRLPG 307

Yeast   333 ---QPPL-----------------------INIGLVGYPNVGKSSTINSLVGAKKVSVSSTPGKT 371
               .|.|                       :.:|:|||||||||||||||:..||||||:|||||
  Fly   308 DKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKT 372

Yeast   372 KHFQTIKLSDSVMLCDCPGLVFPNFAYNKGELVCNGVLPIDQLRDYIGPAGLVAERIPKYYIEAI 436
            |.|||:.|...::||||||||.|:|...|.:::.||:|||||:||::....|:.||||::.:|..
  Fly   373 KRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDK 437

Yeast   437 YGIHIQTKSRDEGGNGDI---PTAQELLVAYARARGYMTQGYGSADEPRASRYILKDYVNGKLLY 498
            |||.|......|    |:   |.::|||:||...||:||.. |..|:.|::||:|||||||:|||
  Fly   438 YGIVIAKPLEGE----DMERPPHSEELLLAYGYNRGFMTSN-GQPDQARSARYVLKDYVNGRLLY 497

Yeast   499 VNPPPHLEDDTPYTREECEEFNKDLYVFDRLPDTRKEQVQNAAKAKGIDIVDLARDLNQLTFSAH 563
            ...||    ..|.|.            :...|:.::..::
  Fly   498 AMSPP----SVPQTE------------YHTFPERQRRVIE------------------------- 521

Yeast   564 TGGDTQKEAKSVTHGGKQAAL---YNAAEDLDRDFFKMN----NVEGRLSTPFHKVQNSS---AG 618
                     :|...|.:|.|:   .:.:::||..||...    :|:||.:.|..::.|..   ||
  Fly   522 ---------ESQLPGQQQRAMRINKSTSKELDNQFFSDKPTHAHVKGRTNFPNVRLANDGSLVAG 577

Yeast   619 K-------RHNKKNKSKNAKSKVFSIENN 640
            .       ||.||.:.:..:.|...::.:
  Fly   578 NDPAAKPWRHVKKERREKLRKKFSHLDEH 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LSG1	NP_011416.3	HSR1_MMR1	187..394	CDD:206750	114/241 (47%)
		RbgA	199..496	CDD:440775	150/334 (45%)
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	114/241 (47%)
		RbgA	176..495	CDD:440775	150/334 (45%)