DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc2a8 and CG33282

DIOPT Version :9

Sequence 1:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus
Sequence 2:	NP_001097067.1	Gene:	CG33282 / 2768939	FlyBaseID:	FBgn0053282	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	465	Identity:	115/465 - (24%)
Similarity:	207/465 - (44%)	Gaps:	42/465 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    24 RRVFLATFAAALGPLSFGFALGYSSPAIPSLRRT-APPALRLGDTAASWFGAVVTLGAAAGGVLG 87
            |...|||....:.....|..:|:.||.:..::.. :|....:.....||.|:::.|.:..|.:..
  Fly    15 RYQLLATVIVNIITFGHGVGVGWLSPTLTKIQTADSPLDFEVNLAQISWLGSMLGLDSLCGNLTI 79

  Rat    88 GWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPA 152
            ..|::|||||..|.|...|:...:.:|..|.:|:.|...|.|.|...|...||.|::|||:|...
  Fly    80 AMLIERAGRKFCLYLMAGPYACIWILIYCASNVYYLYAARFLCGFTGGAGYLVVPIFISEVADSN 144

  Rat   153 VRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQE 217
            :||.|.|.|.|.|..|||..|:....|.:..:..|..:.|....:....:|||..:||.:.|...
  Fly   145 IRGALTSMVMLSVDLGILAGYILSTYLAYHVVPFLAIILPVAYFIANIMLPETAPYLLKKSQLAA 209

  Rat   218 AMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPG-----------VHKPLIIG----ICLMVF 267
            |..:.|:.........|.......:..:.|:|.:..           ..||.:.|    |.|.:.
  Fly   210 AENSFRYYRNQRSAICEQTSKVNFEELRTAVLSQQTRNATPLSYKDLTTKPALKGFAASIVLSLG 274

  Rat   268 QQLSGVNAIMFYANTIFE-EAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMV 331
            .|.|||.:.:.|.:.||: .....|.:.|::.:|::|::....:.:::|..||::|:.:|.:.:.
  Fly   275 YQFSGVFSFINYMSDIFKASGSVVDVNTATIIIGLVQIVGVYTSTILVDIVGRRVLMLISTMGVG 339

  Rat   332 FSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWL 396
            ....|||.:           :::..:..:|        ...||.:..|.:......:|...|.:|
  Fly   340 IGCIAFGCF-----------TYLAKIYDLS--------DFNWLPLVLMIIICYVANIGLIGIFFL 385

  Rat   397 LMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYG---AFWLTAAFCILSVLFTLT 458
            ::.|:||:.|:.:||.:.|:   |::.||.........:|..:|   ..|.:||..:|:..:...
  Fly   386 VLVELFPVKIRSLATSLSVI---FLSLLVFGTLKLFPLMLHYWGISFTMWFSAASALLTFFYFWL 447

  Rat   459 FVPETKGRTL 468
            |:.||||:::
  Fly   448 FLQETKGKSM 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	114/462 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
CG33282	NP_001097067.1	MFS	21..448	CDD:119392	107/448 (24%)
CG33282	NP_001097067.1	MFS_1	53..409	CDD:284993	93/377 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940