DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLA1 and Spf45

DIOPT Version :9

Sequence 1:	NP_009546.1	Gene:	SLA1 / 852276	SGDID:	S000000103	Length:	1244	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001036426.1	Gene:	Spf45 / 3355114	FlyBaseID:	FBgn0086683	Length:	403	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	57/305 - (18%)
Similarity:	94/305 - (30%)	Gaps:	110/305 - (36%)

- Green bases have known domain annotations that are detailed below.

Yeast   555 EKFKANDGSSSRGTDSRD---SERERRRRLKEQEEKERDR---RLKERELYELKKARELLDEERS 613
            ||.|    ..|.|:|...   |:||      ::::||:||   |:..||.|.
  Fly   104 EKLK----EKSNGSDKNRAGVSDRE------DRDDKEKDRKRGRVGRREFYR------------- 145

Yeast   614 RLQEKELPPIK--------------PPRPTSTTSVPNTTSVPPAESSNNNNSSNKYDWFEFFLNC 664
              .|...|.:|              .|.|.........|..||....            |..::.
  Fly   146 --DEVSAPNLKLSGFGHRQNDDDMYLPSPGLVAKQGGATIAPPPSLQ------------EMSIDS 196

Yeast   665 GVDVSNCQRYTINFDREQLTEDMMPDINNSMLRTLGLREGD----------IVRVMKHLDKKFGR 719
            |.:.:|...|:.:            .:...::...|.::|.          |...::...|:.||
  Fly   197 GCEATNTMPYSAS------------SVAAKIMAKYGFKDGQGLGKSEQGMAIALQVEKTSKRGGR 249

Yeast   720 ---ENIASIPTNATGNMFSQPDGSLNVATSPETSLPQQLLPQTTSPAQTAPSTSAETDDAWTVKP 781
               |....:|..|    .|.|.....:.|||.    .:.:|    |.|...:.:...|..:::..
  Fly   250 IIHEKDVFLPPLA----LSPPSIGSQIGTSPS----HKAMP----PPQMVDTAAESGDIGYSITE 302

Yeast   782 ASKSESN-LLSKKSEFTGSMQDLLDLQPLEPKKAAASTPEPNLKD 825
            ..||.|. :|.:.....|.:.:.|               ||.:||
  Fly   303 IMKSPSKVVLLRNMVGPGDVDEEL---------------EPEVKD 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLA1	NP_009546.1	SH3_Sla1p_1	7..64	CDD:212707
		SH3	73..127	CDD:327375
		SH3_Sla1p_3	356..412	CDD:212709
		SHD1	489..554	CDD:309199
		SAM_SLA1_fungal	655..716	CDD:188931	7/70 (10%)
		MotB_plug	<738..848	CDD:330912	17/89 (19%)
		Med15	831..>1201	CDD:312941
Spf45	NP_001036426.1	G-patch	209..248	CDD:279867	4/50 (8%)
Spf45	NP_001036426.1	RRM_UHM_SPF45	307..402	CDD:241091	8/41 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.78878	Normalized mean entropy	S3904
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950