DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FUS3 and rl

DIOPT Version :9

Sequence 1:	NP_009537.1	Gene:	FUS3 / 852265	SGDID:	S000000112	Length:	353	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	176/346 - (50%)
Similarity:	234/346 - (67%)	Gaps:	14/346 - (4%)

- Green bases have known domain annotations that are detailed below.

Yeast     6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70
            ::.:...:...:.:||||||:|.||....|.:.||||||.||:...:..||||||.||..|||||
  Fly    31 IFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHEN 95

Yeast    71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135
            ||.|.:|.|.||.:...:|||:|.||:|||::::.||.||:|||.||:||.||.:|.:|.:||:|
  Fly    96 IIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVLH 160

Yeast   136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG-MTEYVATRWYRAPEVMLTSAK 199
            |||||||||:|..||||:||||||||.|        |....:| :|||||||||||||:||.|..
  Fly   161 RDLKPSNLLLNKTCDLKICDFGLARIAD--------PEHDHTGFLTEYVATRWYRAPEIMLNSKG 217

Yeast   200 YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLP 264
            |::::|:||.||||||:...||||||:.|..||..|.|::|:|..| ||.||.:.:||.|::|||
  Fly   218 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRD-DLECIINEKARNYLESLP 281

Yeast   265 MYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFF 329
            ..|..|..|:||..:...:|||.:||.|:|.|||..:|||.||||:.|:||.|||..| :|   |
  Fly   282 FKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAE-VP---F 342

Yeast   330 EFDHYKEALTTKDLKKLIWNE 350
            ..:...:.::...||.||:.|
  Fly   343 RINMENDDISRDALKSLIFEE 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FUS3	NP_009537.1	STKc_ERK1_2_like	7..353	CDD:270839	176/345 (51%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	176/345 (51%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	160/296 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	323	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I402
Isobase	1	0.950	-	0	Normalized mean entropy	S246
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		otm46891
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1382
SonicParanoid	1	1.000	-	-		X259
TreeFam	1	0.960	-	-
	13	12.800