DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GIN4 and par-1

DIOPT Version :9

Sequence 1:	NP_010795.3	Gene:	GIN4 / 852119	SGDID:	S000002915	Length:	1142	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	1093	Identity:	261/1093 - (23%)
Similarity:	415/1093 - (37%)	Gaps:	291/1093 - (26%)

- Green bases have known domain annotations that are detailed below.

Yeast    16 IGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIER 80
            ||.:||.:|:|.|:..||:||::..||:|.|:|:|.|...|.|::.               .:.|
  Fly   250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQ---------------KLFR 299

Yeast    81 EIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVS 145
            |:.|||:|:|||:::|:.|.||...|||::|||..||:|:.||..|.:.|.||...||||:..|.
  Fly   300 EVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQ 364

Yeast   146 YCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGF 210
            |||...|:|||||.||||||.:.||||||||.:...|.|..|:|.||||.|||||:..|..|.|.
  Fly   365 YCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGP 429

Yeast   211 ASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPE 275
            ..||||.||||:.|::|.||||  ...:|.|..:|.:|::.:|.  .:|.:.::|:||.|.::|.
  Fly   430 EVDVWSLGVILYTLVSGSLPFD--GSTLRELRERVLRGKYRIPF--YMSTDCENLLRKFLVLNPA 490

Yeast   276 RRIKTRDIL-------------KHPLLQKYPSIRDSKSIRGLPREDTYLTPLSESNSSIDATILQ 327
            :|.....|:             ..|.::....:.|.|.|..       |..:..:.|.|:|::.|
  Fly   491 KRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEA-------LVAMGYNRSEIEASLSQ 548

Yeast   328 ---------NLVILWHGRDPE------GIKEKLR-----EPGANAEKTLYALLYRFKCDTQKELI 372
                     .|::.....|||      |....||     :.||||...      ..:..|.:.:
  Fly   549 VRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSA------SVQSPTHRGV- 606

Yeast   373 KQQQVKKRQSISSVSVSPSKKVSTTPQRRRNRESLISVTSSRKKPISFNKFTASSASSSNLTTPG 437
                   .:|||:.|..||::.|          |.:..|::.....:......:...|:|....|
  Fly   607 -------HRSISASSTKPSRRAS----------SGVGPTNAAATVAAATGAVGAVNPSNNYNAAG 654

Yeast   438 SSKRLSKNFSSKKKLSTI----VNQSSPTPASRNKRA------------SVINVEKNQKRASIFS 486
            |:...:...|:.|:.:||    :.:::...|::|:|.            :.:|.....:.|:.:.
  Fly   655 SAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYD 719

Yeast   487 TTKKNKRSSRSIKRMSLIPSMKRESVTTKLMSTYAKLAEDDDWEYIEKETK-----------RTS 540
            .|..|:..|.:   ..:||   |.|.|     .|.|.:..:....|..||.           ::|
  Fly   720 PTNGNRTVSGT---SGIIP---RRSTT-----LYEKTSSTEKTNVIPAETNLFDRLRMASAVKSS 773

Yeast   541 SNFATLIDEIFEYEKYEQIRKEKEELE---------------RKVREAKAREELERRRRKQEEKE 590
            .:|...:.....:...:...:....||               |....:|......:|....:|..
  Fly   774 RHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAA 838

Yeast   591 RARKL-----------LEKEDLKRKQEELKKQIEIDISDLEQ--------------------ELS 624
            :.|.|           |..:.:.:|..|:..|...|....|:                    |:.
  Fly   839 KPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVC 903

Yeast   625 KHKEEKLDGNIRSISAPMENEEKNINHLEVDIDNILRRRNFSLQTRPVSRLDPGIMFSSPTEEVS 689
            |.....|:| :|.         |.|:...:...||..|..|.|:.......:.|...::.:....
  Fly   904 KLPRLSLNG-VRF---------KRISGTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTD 958

Yeast   690 PVEPKRTENERLTTEKKILETIRRSKFLGSSFNIDKELKLSKMEYPSIIAPQRLSEERVVSDSND 754
            |.:...|.|            .||                     ||..:..||||..::..|..
  Fly   959 PTDTMTTTN------------CRR---------------------PSNDSTSRLSELSLLCRSLT 990

Yeast   755 GYESLILPKDGNGVSQLKDSTATTAPVSDGRLRKISEIRVPQFTRKSRHFSESNKRLSVLSMYST 819
            ..:         |..:.|.|..:|....|.:                    :||..||...|||.
  Fly   991 SQQ---------GSQRRKKSRLSTGGSEDQK--------------------KSNSLLSAFQMYSP 1026

Yeast   820 KESFTNLVDILKNGNLDV-NNQQSQRIPTPRSADDSEFLFETVN----EEAEYTGNSSNDERLYD 879
            ..|..|:....:..:|.| :.|....:..|..||     |..:|    |:||........|....
  Fly  1027 FSSKENMQSSEEVEDLHVIDTQPGHSVDVPLFAD-----FSPINPIMEEDAEGVEGGKTSEAKVI 1086

Yeast   880 VGDSTIKDKSALKLNFADRFNGSNEAKQTDNLHLPILPPLNGDNELRKQNSQEGDQAHPKIKSMI 944
            .|.|..|.|       .|...|                  .|.|.|::.....|.....|:.
  Fly  1087 SGGSGQKVK-------GDGGGG------------------GGGNRLKRNIKHTGSLIVRKLT--- 1123

Yeast   945 PESGSSSHTEKEEENEEKEEKKPEQHKQEEDQEKREKVVDDMEPPLNKSVQKI 997
                :..|.:.:::...:::.|.:|...:.|:|:          |.:|...|:
  Fly  1124 ----AGRHNDADKKGAIRKKDKEQQEVADTDKER----------PTSKPEGKV 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GIN4	NP_010795.3	PKc_like	17..289	CDD:419665	119/284 (42%)
GIN4	NP_010795.3	Kcc4p_like_C	1026..1139	CDD:213379
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	117/270 (43%)
		S_TKc	253..504	CDD:214567	117/269 (43%)
		UBA_MARK_Par1	525..563	CDD:270522	9/44 (20%)
		MARK1-3_C	839..936	CDD:213381	19/106 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910