DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITR1 and CG33282

DIOPT Version :9

Sequence 1:	NP_010785.1	Gene:	ITR1 / 852108	SGDID:	S000002905	Length:	584	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001097067.1	Gene:	CG33282 / 2768939	FlyBaseID:	FBgn0053282	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	126/474 - (26%)
Similarity:	200/474 - (42%)	Gaps:	37/474 - (7%)

- Green bases have known domain annotations that are detailed below.

Yeast    80 QSLSPFIITLTFVASISGFMFGYDTGYISSALISIGT---DLDHKVLTYGEKEIVTAATSLGALI 141
            |..:.:.:..|.:.:|..|..|...|::|..|..|.|   .||.:| ...:...:.:...|.:|.
  Fly    11 QQKTRYQLLATVIVNIITFGHGVGVGWLSPTLTKIQTADSPLDFEV-NLAQISWLGSMLGLDSLC 74

Yeast   142 TSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISE 206
            .::......:..|||.||......:....||...|...:.:...|.:.||..|.|.|:.|:||||
  Fly    75 GNLTIAMLIERAGRKFCLYLMAGPYACIWILIYCASNVYYLYAARFLCGFTGGAGYLVVPIFISE 139

Yeast   207 IAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVNNGWRILVGLSLIPTAVQFTCLCFLPDTPR 271
            :|...|||.||.:..|.:..|.|..|.....|.|     .::..|::|.....|.....||:|..
  Fly   140 VADSNIRGALTSMVMLSVDLGILAGYILSTYLAY-----HVVPFLAIILPVAYFIANIMLPETAP 199

Yeast   272 YYVMKGDLARATEVLKRSYTDTSEEIIER--KV--EELVTLNQSIPGKNVPEKVWNTIKELHTVP 332
            |.:.|..|| |.|...|.|.:....|.|:  ||  |||.|...|...:|....   :.|:|.|.|
  Fly   200 YLLKKSQLA-AAENSFRYYRNQRSAICEQTSKVNFEELRTAVLSQQTRNATPL---SYKDLTTKP 260

Yeast   333 SNLRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVG-FKNSSAVSIIVSGTNFIFTLVAFFSIDK 396
            : |:.......|....||:|..|.:.:...||:..| ..:.:..:||:.....:....:...:|.
  Fly   261 A-LKGFAASIVLSLGYQFSGVFSFINYMSDIFKASGSVVDVNTATIIIGLVQIVGVYTSTILVDI 324

Yeast   397 IGRRTILLIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALG 461
            :|||.::||...|:.:..:... .|.:|...:|       .|.| :|..::::.||.:.|...|
  Fly   325 VGRRVLMLISTMGVGIGCIAFG-CFTYLAKIYD-------LSDF-NWLPLVLMIIICYVANIGL- 379

Yeast   462 IGTVPWQQSELFPQNVRGIGTSYATATNWAGSLVIAST---FLTMLQNITPAGTFAFFAGLSCLS 523
            ||.......||||..:|.:.||.:....   ||::..|   |..||.....:.|. :|:..|.|.
  Fly   380 IGIFFLVLVELFPVKIRSLATSLSVIFL---SLLVFGTLKLFPLMLHYWGISFTM-WFSAASALL 440

Yeast   524 TIFCYFCY-PELSGLELEE 541
            |.|.::.: .|..|..:.|
  Fly   441 TFFYFWLFLQETKGKSMIE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	121/452 (27%)
CG33282	NP_001097067.1	MFS	21..448	CDD:119392	122/451 (27%)
CG33282	NP_001097067.1	MFS_1	53..409	CDD:284993	100/379 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13428
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840