DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SUP35 and eEF1alpha1

DIOPT Version :9

Sequence 1:	NP_010457.3	Gene:	SUP35 / 851752	SGDID:	S000002579	Length:	685	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	165/461 - (35%)
Similarity:	262/461 - (56%)	Gaps:	38/461 - (8%)

- Green bases have known domain annotations that are detailed below.

Yeast   257 GKD--HVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEE 319
            ||:  |::::.:||||:||||..|:|:|..|.:|||||||:|:||::.|:..:..:||:|..|.|
  Fly     2 GKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAE 66

Yeast   320 RNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGG 384
            |..|.||::....|||.|...||:|||||:.::..||.|.||||..||:::|..||:|.|..:.|
  Fly    67 RERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNG 131

Yeast   385 QTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSG 449
            |||||||||.|.||.:::|.|||||.....:|:.||::....||::::.|||| ...|.|:|:||
  Fly   132 QTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYN-PAAVAFVPISG 195

Yeast   450 YSGANLKDHVDPK-ECPWY------------TGPTLLEYLDTMNHVDRHINAPFMLPI--AAKMK 499
            :.|.|:   ::|. ..||:            .|.||::.||.:....|..:....||:  ..|:.
  Fly   196 WHGDNM---LEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIG 257

Yeast   500 DLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETENE-VDMAMCGEQVKLRIKGVEEEDI 563
            .:||:..|::|:|.:|.|...:..|.....|::::  |..:| :..|:.|:.|...:|.|..:::
  Fly   258 GIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSV--EMHHEALQEAVPGDNVGFNVKNVSVKEL 320

Yeast   564 SPGFVLTSPK-NPIKSVTKFVAQIAIVELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGTNR 627
            ..|:|....| ||.|....|.||:.::.....||.|::.|:..|||.......::..|:::.:.:
  Fly   321 RRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGK 385

Yeast   628 KSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYPQLGRFTLRDQGTTIAI-------------GK 679
            .:::.|.|.|.|...|..|....|:|||.:|::|.||||.:||...|:|:             ||
  Fly   386 TTEENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGK 450

Yeast   680 IVKIAE 685
            :.|.||
  Fly   451 VTKAAE 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SUP35	NP_010457.3	PRK10263	<30..>199	CDD:236669
SUP35	NP_010457.3	TEF1	254..685	CDD:227581	163/459 (36%)
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	165/461 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	0	0.000	Not matched by this tool.
	3	2.810