DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VPS41 and lt

DIOPT Version :9

Sequence 1:	NP_010365.3	Gene:	VPS41 / 851653	SGDID:	S000002487	Length:	992	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	202/923 - (21%)
Similarity:	373/923 - (40%)	Gaps:	211/923 - (22%)

- Green bases have known domain annotations that are detailed below.

Yeast    93 DDEDEPPLLKYTRISQLPKNFFQRDSISSCLFGDTFFAFGTHSGIL----HLTTCAFEPIKTIKC 153
            ::||..|..||.|::...|.....|.|:.......|..|||..|.:    |.....:..:...:.
  Fly    18 NEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNLSASER 82

Yeast   154 HRSSILCINTD----GKYFATGSIDGTVIIGSMDDPQNITQYDFKRPINSVALHSNFQAS-RMFV 213
            |...:...|.|    |:|.||.|.||.|.|..:....|.....|.:.|..|:|..:.:|. :.||
  Fly    83 HTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPDSKAHIKRFV 147

Yeast   214 SGGMAGDVVLSQRNWLGNRIDIVLNKKKKKKTRKDDLSSDMKGPIMGIYTMGDLILWMDDDGITF 278
            .|.  ..::|.:||.|             ||.:..:|.| ::|.::.|...|:.|.|....|:..
  Fly   148 VGD--DKLILYERNLL-------------KKLKPVELCS-VEGSVLSICWHGNFIAWASHIGVRV 196

Yeast   279 CDVPTRSQL----LNIPFPSRIFNVQDVRPDLFRPHVHFLESDRVVIGWGSNIWLFKVSFTKDSN 339
            .|:..|..|    ..:|...|:.|        ||.|:.:.....::|||...|   :|...:..|
  Fly   197 YDLNERCSLGLIKWEVPPQERLEN--------FRCHLRWSNKHTLLIGWVDTI---RVCVIRKRN 250

Yeast   340 SIKSGDSNSQSNNMSHFNPTTNIGSLLSSAASSFRGTPDKKVELECHFTVSMLITGLASFKDDQL 404
            ||::.              |.|:...:....|:|:.|              ..:.|||.....||
  Fly   251 SIEAS--------------TGNLPVYIVDPISTFQTT--------------FYVCGLAPLSAKQL 287

Yeast   405 LCLGFDIDIEEEATIDEDMKEGKNFSKRPENLLAKGNAPELKIVD--LFNGDEIYNDEVIMKNYE 467
            :.|||                     ::.::...|...|.|.:::  :.|.:||..|.:.::.:|
  Fly   288 VVLGF---------------------RKEKSSCFKALRPVLCVIEYKMNNSEEICTDSLTLRGFE 331

Yeast   468 KLSINDYHLGKHIDKTTPEYYLISSNDAIRVQELSLKDHFDWFMERKQYYKAWKIGKYVIGSEER 532
            :.::|||.||..|::.  .:|:::..|.:....:...|..:|.::..::.:|.::.....|:...
  Fly   332 EYTVNDYSLGGIIEEN--RFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGGNVPV 394

Yeast   533 FSIGLKFLNSLVTKKDWGTLVDHLNIIFEETLNSLDSNSYDVTQNVLKEWADIIEILITSGNIVE 597
            .|:...::|.|:..|.:.   |...:......|          ..||  |.:.:...:....:..
  Fly   395 LSVAKLYINHLLALKKYD---DAAKLCLRMLGN----------DKVL--WEEEVFKFVKCQQLRS 444

Yeast   598 IAPLIPKKP--ALRKSVYDDVLHYFLANDMINKFHEYITKWDLKLF-------SVED-FEEELET 652
            ::..:|...  .|...||:.||:.||..|:.. |...|.:|...|:       ::.| |.:.
  Fly   445 VSAYLPTSDECKLDPHVYEMVLYEFLKFDVCG-FLNLIKEWPSHLYDGLAVINAIHDNFRKH--- 505

Yeast   653 RIEAASEPTASSKEEGSNITYRTELVH----LYLKENKYTKAIPHLLKAKDLRALTIIKIQNLLP 713
                                |..:|:.    ||..:..:..|:...||.::.....:|:
  Fly   506 --------------------YANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIR------ 544

Yeast   714 QYLDQIVDIILLPYKGEISHISKLSIFEIQTIFNKPIDLLFENRHTISVARIYEIFEHDCPKSFK 778
            :|  ::.|:           ||||.|..||...:...::|.:.:...:...:::: ||:     :
  Fly   545 RY--ELYDV-----------ISKLIIPLIQLDRDCAFEILLDKKKIKTEIVVHQL-EHN-----Q 590

Yeast   779 KILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSLLPFLQKHNNYNVESAIEVCSSKLGLYN 843
            :.|:.||...|..|.|   :.::.:||.||:.:||..|||||::..:|:::.|:.:|..: ..|.
  Fly   591 EYLYWYLDSLLKKDPS---NVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVICKQE-NFYP 651

Yeast   844 ELIYLWGKIG--ETKKALSLIIDELKNPQLAIDFVKNWGDSELWEFMINYSLDKPNFTKAILTCS 906
            |::||.|.:|  |..:||::||..:::.::||:|.|...||:||..:||      .|:|
  Fly   652 EIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALIN------EFSK------ 704

Yeast   907 DETSEIYLKVIRGMSD-------------DLQIDNLQDIIKHIVQENSLSLEVRDNILVIINDET 958
              ..||..||:.|:.|             ...|.||:..:..:::..:|..|       |::...
  Fly   705 --HPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGE-------ILSSAQ 760

Yeast   959 KKFANEFLKIRSQ 971
            :...|::.:|.|:
  Fly   761 QIQLNDYFEIHSE 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VPS41	NP_010365.3	WD40	145..179	CDD:197651	11/37 (30%)
VPS41	NP_010365.3	CLH	753..896	CDD:128594	44/144 (31%)
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	9/47 (19%)
		WD40	<42..204	CDD:295369	45/177 (25%)
		WD40 repeat	90..123	CDD:293791	12/32 (38%)
		WD40 repeat	130..168	CDD:293791	13/52 (25%)
		CLH	570..707	CDD:128594	46/160 (29%)
		Clathrin	580..708	CDD:279031	45/151 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346577
Domainoid	1	1.000	90	1.000	Domainoid score	I1769
eggNOG	1	0.900	-	-		E1_KOG2066
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I1109
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S2845
OMA	1	1.010	-	-		QHG54432
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto99401
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1654
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.740