Protein Alignment ITGA8 and ItgaPS5

DIOPT Version :10

• Sequence 1: NP_003629.2
• Gene: ITGA8 / 8516
• HGNCID: 6144
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Alignment Length: 1085
• Identity: 281/1085 - (25%)
• Similarity: 442/1085 - (40%)
• Gaps: 206/1085 - (18%)

Human    53 KGSYFGYAVDFHIPDARTASVLVGAPKANT---SQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTT 114
            :.|||||::..     |..|:.||||:|.:   ||..|.|.||||.||. |.||  |.....:..
  Fly    43 RSSYFGYSLVI-----RPTSIFVGAPRAQSTLESQGSINETGAVYRCPL-ASGS--CSHYVLNDK 99

Human   115 NNRKIRVNGTKEPIEFKSNQWFGATVKA---HKGKVVACAPLYHWRTLKPTPEKDPV----GTCY 172
            .|::.              ||.|.::..   ...|::.|||.:.      .|:....    |.||
  Fly   100 LNKQF--------------QWLGGSMDGGTKDTDKLLVCAPRFF------VPKNKNYGQMRGICY 144

Human   173 VAIQNFSAYAEFSPCRNSNADP---EGQGYCQAGFSLDFY-KNGDLIVGGPGSFYWQGQVITASV 233
            ......:.....|..|..:..|   |.....:.|.|.... .|...::|.||...|:|.|:....
  Fly   145 WVRDTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRG 209

Human   234 ADIIA--NYSFKDILRKLAGEKQTEVAPASYD-----DSYLGYSVAAGEFTGDSQQEL--VAGIP 289
            .|:.|  :|:.|.:              .|:|     .:|:||::::|.|:.:::..|  |...|
  Fly   210 EDLAAQGSYAVKML--------------DSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAP 260

Human   290 RGAQNFG--YVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFES 352
            ....|.|  |:..:....:..:..|.|||:..||||:||..|:|.|||.||:|.|||    ....
  Fly   261 SSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALG 321

Human   353 NPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRG 417
            :..:||.||:::......|....|.....:..||||:::.:||:|.|||||:|:|.||||   .|
  Fly   322 DSYDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAG---NG 383

Human   418 KVLIYNGNKDGLNTKPSQVLQ------GVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTG 476
            .|.|:.|::.||..:|||.|.      |.:.:|.    ||..|...||||.|.:.||.:||.|..
  Fly   384 AVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHM----FGQGLSRGSDIDGNGFNDLAIGAPGAE 444

Human   477 KVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAE 541
            .|.:|||.|||.:.|.:......|..|.:|      :|..||:.|...:..            .:
  Fly   445 AVYLYRAYPVVKIHATVRSESRAIRPEQET------ITVTACYRLETTSKA------------RQ 491

Human   542 VQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQK--SHQCQDFIVYLRDETEFRDKLSPINISL 604
            :|...|..:..|...|...:....|...:..:.|.  |..|::|.|.:......   .:||::.|
  Fly   492 MQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGGI---FTPIDLEL 553

Human   605 NYSL------DESTFKEGLE-VKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQV 662
            :|.|      ....|.|... |.|:...|....:|    .:..|.. ::||.||:||::......
  Fly   554 HYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLS----FMTGCAA-HVCVSDLQLSSKDVNSSF 613

Human   663 IIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCD 727
            |.|....|.......|.||.||.|:..|.......:..:        |.:|..:.|    :::||
  Fly   614 IFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKV--------PGNCRVRHE----VMLCD 666

Human   728 L--GNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKD-NPDSNFVSLQINITAVAQVEI 789
            |  |..:..|.:.||.:.|.|.:|  :..|:..:..:.|:..| ||..|.:|..|::...|:::.
  Fly   667 LNGGRALARGDSESLTIIFDVTQL--SGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDA 729

Human   790 RGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLL 854
            .|......|.|       :|.|:..|     |.:.||..:.|||.|.:..:.|..|.:.......
  Fly   730 SGGPIDGHIAL-------KEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSA 782

Human   855 YIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELS-AFLRNSTIPHLVRKR------------ 906
            .|..|..:..||.|..   :..::.|....:.|..|: .:....:.....|||
  Fly   783 GIKSIFNISSLQMQAT---HGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMP 844

Human   907 DVHVVEFHRQSPAKILNCTNI---ECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYAL 968
            ||::        :.||...|:   ..|.:.|..|      :..:.|||::....   :...|..|
  Fly   845 DVNI--------SDILTKENLPANRTLVLDCLRG------NWTICVRSQMRVQL---KPEQPIDL 892

Human   969 ASLVSFEVKKMPYTD---------QPAKLPEG---SIVIKTSVIWATPNVSFS-----IPLWVII 1016
            .  :||:|....:.:         ......||   ||.:|.::   .|||.|:     :|:|.||
  Fly   893 R--ISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNL---KPNVIFNYSETPLPIWYII 952

Human  1017 LAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTP 1061
            |:::.|.|:|..:|..|:|..||.|.:..:......|..:..|.|
  Fly   953 LSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEP 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA8	NP_003629.2	Int_alpha	54..112	CDD:214549	26/60 (43%)
		Int_alpha	263..311	CDD:214549	12/56 (21%)
		Int_alpha	317..>365	CDD:214549	21/47 (45%)
		Int_alpha	383..437	CDD:214549	27/53 (51%)
		Int_alpha	448..492	CDD:214549	20/43 (47%)
		Integrin_alpha2	484..934	CDD:462478	103/477 (22%)
		Integrin_alpha	1035..1049	CDD:459778	4/13 (31%)
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	20/41 (49%)
		Int_alpha	351..403	CDD:214549	27/54 (50%)
		Int_alpha	417..463	CDD:214549	21/49 (43%)
		Integrin_alpha2	453..837	CDD:462478	97/438 (22%)