Protein Alignment ITGA8 and scb

DIOPT Version :10

• Sequence 1: NP_003629.2
• Gene: ITGA8 / 8516
• HGNCID: 6144
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Alignment Length: 1195
• Identity: 290/1195 - (24%)
• Similarity: 471/1195 - (39%)
• Gaps: 259/1195 - (21%)

Human    27 LGMLLWSPACQAFNLDVEKLTVYSGPK----------GSYFGYAVDFHIPDARTASVLVGAPKAN 81
            |.:|......:|||.......|.:.||          .|||||.:..     |..|::||||:|.
  Fly    13 LALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVI-----RQTSIIVGAPRAQ 72

Human    82 T---SQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKA- 142
            :   ||..|.|.||:|.|   :..:..|.....|:..|.....:......|.|..||.|.::..
  Fly    73 STLESQRTINETGAIYRC---SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGG 134

Human   143 --HKGKVVACAPLYHWRTLKPTPEKDPV-GTCYVAIQNFSA-----YAEFSPCR--NSNADPEGQ 197
              ...|::.|||.::    .|:...:.: |.|| .:.|..|     ....||.|  :.....|..
  Fly   135 TKDTDKLLVCAPRFY----APSSRDNHLHGVCY-WVNNTVASTPQHVTRISPLRLKSEQVKEEDN 194

Human   198 GYCQAGFSLDFYKNGDL-------------IVGGPGSFYWQGQVITASVADIIAN------YSFK 243
            |. :|.|   ||..|:|             ::|.||...|:|.||.....|.:.|      .:.|
  Fly   195 GN-KASF---FYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSK 255

Human   244 DILRKLAGEKQTEVAPASY-------------DDSYLGYSVAAGEFTGDSQQEL--VAGIPRGAQ 293
            .:.|........:..|..|             :|||.||:|::|.|...:..:|  ||..|:..:
  Fly   256 ALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANK 320

Human   294 NFG--YVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPRE 356
            ..|  |:..:....:.....|.|||...||||:|:..|:|.||..||:|.||.....:...|
  Fly   321 QSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDN--- 382

Human   357 VGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLI 421
             |.||:::......|....:.:..||..|||:|::.|||:|.|||||:|:|.||||   .|.|.|
  Fly   383 -GAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGTVFI 443

Human   422 YNGNKDGLNTKPSQVLQ------GVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAV 480
            |.|:::||..:|||.|.      ..:.||.    ||..|...||||.|.:.|..:||.....|.:
  Fly   444 YLGSENGLRDQPSQRLDAPSQQPSKYGSHM----FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYL 504

Human   481 YRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLD 545
            |||.|||.|.|.:......|..|.:..::      .||:.|   ::.:...:.....|...:.:|
  Fly   505 YRAYPVVKVHATVKSESREIKPEQEKVKI------TACYRL---STTSTDKLVQEQELAIRIAMD 560

Human   546 SLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFR----DKLSPINISLNY 606
              ||...:|.|....|..:.:|     ......||:||      ||:.|    |..:||::.::|
  Fly   561 --KQLKRVKFTQTQTNEISFKV-----NANFGEQCRDF------ETQVRYSEKDIFTPIDLEMHY 612

Human   607 SLDEST--FKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENH 669
            .|.:..  .:|..|...|::.....:.::.......|..| :|..||:|.::......|:|..:.
  Fly   613 ELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSPTYILGSADT 676

Human   670 LMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDL--GNPM 732
            |.|.....|.||.||..:..|.......:..:        |.:|:.    |..::||||  |.|:
  Fly   677 LRLNYEITNIGETAYLPQFNVTSTSRLAFAQV--------PGNCKV----VDAVMVCDLNRGRPL 729

Human   733 VSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQ 797
            ..|...|:.:.|.|.:|...::.|:.:: ..:..:.||..|..:..|.:....:::..|.....|
  Fly   730 AKGDTDSVTISFDVSQLSGQSLIIHAEV-FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQ 793

Human   798 IVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFS---ARDEFLLYIFHI 859
            |.|..::...|            :.:.||:.:.|||.|....:....|.:   |....::.|.::
  Fly   794 IDLEHYSNSAE------------IVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINV 846

Human   860 QTL-------------------------GPLQCQP-----------NPNINPQDIKPAASPEDTP 888
            .:|                         .|::...           ..|....||..:.....|.
  Fly   847 TSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTM 911

Human   889 ELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKI------------------------LNCTNIE- 928
            |:......:|.....::||:..:..:|:..|:|                        .||.:.|
  Fly   912 EVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEM 976

Human   929 --CLQISCAVGRLEGGESAVLKVRSRL------------WAHTF------LQRKNDPYALASLVS 973
              |::....| .....:|..|.:|..:            |.:..      ||:|.||    :..|
  Fly   977 TICVRAEMRV-HFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDP----TSTS 1036

Human   974 FEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGF 1038
            |.:.:.               |:.::|  :.:....:|:|:||::::.|||:|:.::..|:|.||
  Fly  1037 FSINRR---------------IEPNII--SKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGF 1084

Human  1039 FDRARPPQEDMTDREQLTNDKTPEA 1063
            |:|.:   :|..||....|...|||
  Fly  1085 FNRTK---KDELDRLVQQNPVEPEA 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA8	NP_003629.2	Int_alpha	54..112	CDD:214549	21/60 (35%)
		Int_alpha	263..311	CDD:214549	14/51 (27%)
		Int_alpha	317..>365	CDD:214549	18/47 (38%)
		Int_alpha	383..437	CDD:214549	29/53 (55%)
		Int_alpha	448..492	CDD:214549	19/43 (44%)
		Integrin_alpha2	484..934	CDD:462478	99/523 (19%)
		Integrin_alpha	1035..1049	CDD:459778	5/13 (38%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	21/59 (36%)
		FG-GAP	350..388	CDD:460357	17/41 (41%)
		Int_alpha	409..459	CDD:214549	29/52 (56%)
		Int_alpha	473..>515	CDD:214549	19/45 (42%)
		Integrin_alpha2	509..829	CDD:462478	79/367 (22%)