DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITGA8 and if

DIOPT Version :9

Sequence 1:	NP_003629.2	Gene:	ITGA8 / 8516	HGNCID:	6144	Length:	1063	Species:	Homo sapiens
Sequence 2:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	1406	Identity:	358/1406 - (25%)
Similarity:	564/1406 - (40%)	Gaps:	398/1406 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    20 LCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFH------IPDARTASVLVGAP 78
            |.|...:|.:||.:.:...:|:|:.....:.....|.||:::..|      ..:....|::||||
  Fly    13 LHCPITSLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAP 77

Human    79 KANTS--QPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVK 141
            |.:||  |..:.|.|.|:.|   :.....|:.:|||:..|.:   |..||.::.||.||.||||.
  Fly    78 KFDTSRYQQGVTEAGGVFKC---SLNDDDCKLVPFDSKGNNR---NVDKEVVDRKSYQWLGATVA 136

Human   142 AHKGK--VVACAPLYHWRTLKPTPEK----DPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYC 200
            ..:..  ||||||.|.:.|:  ||.:    ||||||:.: .||..:.|.||||.:|.....||.|
  Fly   137 TGRDSDLVVACAPRYVFHTM--TPSRAFRIDPVGTCFTS-HNFEEFYEVSPCRTNNWGYHRQGSC 198

Human   201 QAGFSLDFYKNGD-LIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAG------------- 251
            |||||.....||. |.:|.|||:|||||  |.|:.. .|.:.||..|.:..|
  Fly   199 QAGFSAAINGNGSRLFIGAPGSWYWQGQ--TYSIPP-DAKFPFKPPLYQPFGTGGMASSHDVTRP 260

Human   252 EKQ---TEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFT 313
            |.|   |..:.:..||||||||:..|:|.||..:::..|:|||....|.: ::|..:|..|.|.|
  Fly   261 ENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNIT 324

Human   314 GEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQIYLYLQ---VSSLLFRDPQ 375
            |.|:..||||::..|||:.|||||:|:|||::.:.:......:||::|:.||   .....:....
  Fly   325 GRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEH 389

Human   376 ILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGLNTKPSQVLQG- 439
            |..|..:.||||.|:..|||:|.|||.|.|:|.|:.|.:.||.|.|::|:..|...||||:::.
  Fly   390 IRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSE 454

Human   440 -VWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ--LLLHPMIIN 501
             :......|..|||.|.|..|:|.|.||||.|||:.:.:|.::::|||..|:|:  ...:..:|:
  Fly   455 QLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLIS 519

Human   502 LENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHR 566
            |::::||:........|..|..|.|.||:.:...:.......||:   |..:...:|....:...
  Fly   520 LDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDA---KKLLNPRMFFLRDEGKN 581

Human   567 VFPLVIKRQKSHQ-CQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLE------VKPILN 624
            :....|:.....: |.:..|||.|:.:  |||:|:.:...|:|..|...:.:.      ::|:::
  Fly   582 IRNQTIRLNYGQKYCLNETVYLLDKVQ--DKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVID 644

Human   625 YYRENIVSEQAHILVDCGEDNLCVPDLKLS-ARPDKHQVIIGDENHLMLIINARNEGEGAYEAEL 688
            ..||.::.:..:|..:||.||:|.|||||. :..||:  :.|....|::.:...|..|.|:||..
  Fly   645 QNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKY--LFGSPEPLVIEVFISNTNEDAFEAAF 707

Human   689 FVMIPEEADYVGIER-NNKGFRPLSCEYKMENVTRMVVCDLGNPMVSG--TNYSLGLRFAVPRLE 750
            :::.|.:..:..::: ..|...|::|..........:.||:|||:.||  .::.:.|   ||. |
  Fly   708 YMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISL---VPE-E 768

Human   751 KTNMSINFDL--QIRSSNKDNPDS---NFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEE 810
            |...|.::|.  :..|:|.:.|.|   |.:...:.|.....::|:|.|.|...:....:::..|.
  Fly   769 KYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELEN 833

Human   811 PHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFS--ARDEFLLYIFHIQTLGPLQC------ 867
            ..||:::||.|.||||:.|..||.|.:..:.:..|:.  ..|..:..:...:|.|.:||
  Fly   834 ATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFN 898

Human   868 ----------------QPNPNI--------------------------------------NPQDI 878
                            |....|                                      |..|.
  Fly   899 EYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDA 963

Human   879 KPAASP--------EDTPEL-----------------------------------------SAFL 894
            ....||        |||.|.                                         ||.|
  Fly   964 GDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQL 1028

Human   895 R-NSTIPHLV------------------------------------------------------R 904
            | :||..|:.                                                      |
  Fly  1029 RGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGR 1093

Human   905 KRDVHV--------------VEFHR-----QSPAKILN--------------------------- 923
            ..:.|.              .|.:|     |:|::.|.
  Fly  1094 NNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARN 1158

Human   924 ----------------------------------------------------------------- 923

  Fly  1159 PGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSS 1223

Human   924 -----------------------------CTNIECLQISCAVGRL--EGGESAVLKVRSRLWAHT 957
                                         |.:..|..|.|.|..|  |.|::|.:.:|:|:.|.|
  Fly  1224 SSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKT 1288

Human   958 FLQ-RKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIW--ATP---NVSFSIPLWVII 1016
            ..: ..|.|..:::|....|..:|:...|.     ..::||..|:  |.|   .|...:||||::
  Fly  1289 MEKLASNVPLNVSTLAVANVTLLPFIGAPK-----DAIVKTHEIFYKAEPEPLQVPDVVPLWVVV 1348

Human  1017 LAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTN 1057
            ||...|.|:..:|...|:|||||:|.||..... :|:.|.|
  Fly  1349 LAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQ-ERQPLRN 1388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITGA8	NP_003629.2	Int_alpha	54..112	CDD:214549	19/65 (29%)
		Int_alpha	263..311	CDD:214549	20/47 (43%)
		Int_alpha	317..>365	CDD:214549	19/47 (40%)
		Int_alpha	383..437	CDD:214549	27/53 (51%)
		Int_alpha	448..492	CDD:214549	20/43 (47%)
		Integrin_alpha2	483..934	CDD:285619	130/774 (17%)
		Integrin_alpha	1035..1049	CDD:278771	8/13 (62%)
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	19/66 (29%)
		Int_alpha	275..>316	CDD:214549	18/41 (44%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	102/404 (25%)
		DUF2756	<1120..1178	CDD:298627	3/57 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142036
Domainoid	1	1.000	175	1.000	Domainoid score	I3647
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37396
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1389
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm41436
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2711
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790