DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRK1 and par-1

DIOPT Version :9

Sequence 1:	NP_010204.1	Gene:	MRK1 / 851480	SGDID:	S000002237	Length:	501	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	105/430 - (24%)
Similarity:	166/430 - (38%)	Gaps:	118/430 - (27%)

- Green bases have known domain annotations that are detailed below.

Yeast    53 HHTVPNFNNSSEYINDIENLIISKLIDGGKEGIAVDHIEH------------ANISDSKTDGKVA 105
            ||...|.......::...:.:::        ..|::|..|            .|:..:.:....|
  Fly   163 HHVANNMTTDGARLSSNNSAVVA--------SSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSA 219

Yeast   106 NKHENISSKLSKEKVEKMINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNHGGTIDISYPTTEVV 170
            .|....|:| ....::...:...|:..|:|                    |.|    .|...:.:
  Fly   220 IKQRTSSAK-GSPNMQMRSSAPMRWRATEE--------------------HIG----KYKLIKTI 259

Yeast   171 GHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN--------RELETMKMLCHPNTVGLQYYFYEK 227
            |.|:|..|.....:.|.::||||.:  |:...|        ||:..||||.|||.|.|   |...
  Fly   260 GKGNFAKVKLAKHLPTGKEVAIKII--DKTQLNPGSLQKLFREVRIMKMLDHPNIVKL---FQVI 319

Yeast   228 DEEDEVYLNL-------VLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRI 285
            :.|..:||.:       |.||:          .::.:|:.....:||  .|:..|:.|.|. .||
  Fly   320 ETEKTLYLIMEYASGGEVFDYL----------VLHGRMKEKEARVKF--RQIVSAVQYCHQ-KRI 371

Yeast   286 CHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWS 350
            .|||:|.:|||:| :..:.||.|||.:....|.....::..|..|.||||..|......:|||||
  Fly   372 IHRDLKAENLLLD-SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 435

Yeast   351 SACVIAELLLGKPLFSGESGIDQLVEII--------------------KIMGI-PTK----DEIS 390
            ...::..|:.|...|.| |.:.:|.|.:                    |.:.: |.|    :.|.
  Fly   436 LGVILYTLVSGSLPFDG-STLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIM 499

Yeast   391 G---MNPNY-EDHVFPNIKPITLAEIFKAE--DPDTLDLL 424
            |   ||..: ||.:.|.|:|       ||:  ||..::.|
  Fly   500 GDKWMNMGFEEDELKPYIEP-------KADLADPKRIEAL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRK1	NP_010204.1	STKc_GSK3	159..449	CDD:271039	89/312 (29%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	77/271 (28%)
		S_TKc	253..504	CDD:214567	77/270 (29%)
		UBA_MARK_Par1	525..563	CDD:270522	3/8 (38%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000