DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MPH2 and CG33282

DIOPT Version :9

Sequence 1:	NP_010034.1	Gene:	MPH2 / 851350	SGDID:	S000002406	Length:	609	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001097067.1	Gene:	CG33282 / 2768939	FlyBaseID:	FBgn0053282	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	93/472 - (19%)
Similarity:	177/472 - (37%)	Gaps:	113/472 - (23%)

- Green bases have known domain annotations that are detailed below.

Yeast   136 DKTGEWEIS---ASW---QIGL-TLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAFTFIL 193
            |...::|::   .||   .:|| :||   |.:....|    ::..|.::.|.:.....|....::
  Fly    49 DSPLDFEVNLAQISWLGSMLGLDSLC---GNLTIAML----IERAGRKFCLYLMAGPYACIWILI 106

Yeast   194 YFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNS 258
            |..:::..:...:.|||...|....:...:.||:....:|..||:...|....|.|  ||.:.::
  Fly   107 YCASNVYYLYAARFLCGFTGGAGYLVVPIFISEVADSNIRGALTSMVMLSVDLGIL--AGYILST 169

Yeast   259 QKKYADSELGYKLPFALQWILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLSGKGPEKEI 323
            ...|      :.:|| |..||||...:.....||:..:|:||.:...|..|.|...:.:....|.
  Fly   170 YLAY------HVVPF-LAIILPVAYFIANIMLPETAPYLLKKSQLAAAENSFRYYRNQRSAICEQ 227

Yeast   324 LVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQATCGSILIGYSTYFYE 388
            ...:..::::..:..::...:...||.|.           .|.....|.|....:.:||
  Fly   228 TSKVNFEELRTAVLSQQTRNATPLSYKDL-----------TTKPALKGFAASIVLSLGY------ 275

Yeast   389 KAGVSTEMSFTFSIIQYCLGI-----------CATFLSWWASKYFGRYDLYAFGLAFQTIVFFII 442
                  :.|..||.|.|...|           .||.:       .|...:  .|:...||:..|:
  Fly   276 ------QFSGVFSFINYMSDIFKASGSVVDVNTATII-------IGLVQI--VGVYTSTILVDIV 325

Yeast   443 G------------GLGCSS----THGSKMGSGS--------LLMAVAFFYNLGIAPVVFCLVSEM 483
            |            |:||.:    |:.:|:...|        |::.:.:..|:|:..:.|.::.|:
  Fly   326 GRRVLMLISTMGVGIGCIAFGCFTYLAKIYDLSDFNWLPLVLMIIICYVANIGLIGIFFLVLVEL 390

Yeast   484 PSSRLRT-----KTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSG-----FFWGVLCFCTL 538
            ...::|:     ..|.|:...:..:.:...:|..:.::...| :.|.|.     :||
  Fly   391 FPVKIRSLATSLSVIFLSLLVFGTLKLFPLMLHYWGISFTMW-FSAASALLTFFYFW-------- 446

Yeast   539 IWAVVDLPETAGKTFVE 555
                :.|.||.||:.:|
  Fly   447 ----LFLQETKGKSMIE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPH2	NP_010034.1	SP	72..556	CDD:273317	93/472 (20%)
CG33282	NP_001097067.1	MFS	21..448	CDD:119392	87/459 (19%)
CG33282	NP_001097067.1	MFS_1	53..409	CDD:284993	80/403 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830