DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TPD3 and Pp2A-29B

DIOPT Version :9

Sequence 1:	NP_009386.1	Gene:	TPD3 / 851217	SGDID:	S000000014	Length:	635	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	604	Identity:	274/604 - (45%)
Similarity:	371/604 - (61%)	Gaps:	23/604 - (3%)

- Green bases have known domain annotations that are detailed below.

Yeast    27 SKDSDSNESLYPLALLMDELKHDDIANRVEAMKKLDTIALALGPERTRNELIPFLTEVAQDDEDE 91
            :.|...::||||:|:|:||||::|:..|:.::|||.|||||||.||||:||||||||... ||||
  Fly     3 ASDKSVDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIY-DEDE 66

Yeast    92 VFAVLAEQLGKFVPYIGGPQYATILLPVLEILASAEETLVREKAVDSLNNVAQELSQEQLFSDFV 156
            |...||:|||.|...:|||::|..|:|.||.||:.|||:||:|||:||..||.|.|.:.|....|
  Fly    67 VLLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHVV 131

Yeast   157 PLIEHLATADWFSSKVSACGLFKSVIVRIKDDSLRKNILALYLQLAQDDTPMVKRAVGKNLPILI 221
            |.::.|.:.|||:|:.||||||.....|: ...::..:.|.:.:|.||:||||:||....|....
  Fly   132 PTLQRLVSGDWFTSRTSACGLFSVCYPRV-TQPVKAELRANFRKLCQDETPMVRRAAANKLGEFA 195

Yeast   222 DLLTQNLGLSTDEDWDYISNIFQKIINDNQDSVKFLAVDCLISILKFFNAKGDESHTQDLLNSAV 286
            .::......|     |.|.| |.::..|:||||:.|||:..:||.:.. .:.|..|.  :|.:..
  Fly   196 KVVETEYLKS-----DLIPN-FVQLAQDDQDSVRLLAVEACVSIAQLL-PQDDVEHL--VLPTLR 251

Yeast   287 KLIGDEAWRVRYMAADRFSDLASQFSSNQAYIDELVQPFLNLCEDNEGDVREAVAKQVSGFAKFL 351
            :...|.:||||||.|::|.||..........:| ||..|..|.:|.|.:||.|||.:|..|...|
  Fly   252 QCASDSSWRVRYMVAEKFVDLQKAVGPEITRVD-LVPAFQYLLKDAEAEVRAAVATKVKDFCANL 315

Yeast   352 ---NDPSIILNKILPAVQNLSMDESETVRSALASKITNIVLLLNKDQVINNFLPILLNMLRDEFP 413
               |...|||:.|||.|::|..|.:..|:|||||.|..:..:|...|.:...||:.|..|:||.|
  Fly   316 DKVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECP 380

Yeast   414 DVRLNIIASLKVVNDVIGIELLSDSLLPAITELAKDVNWRVRMAIIEYIPILAEQLGMQFFDQQL 478
            :||||||::|..|||||||:.||.||||||.|||:|..||||:|||||:|.||.|||.:||||:|
  Fly   381 EVRLNIISNLDCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKL 445

Yeast   479 SDLCLSWLWDTVYSIREAAVNNLKRLTEIFGSDWCRDEIISRLLKFDLQLLENFVSRFTILSALT 543
            ..||:.||.|.||:|||||..|:|:|.|.||:.|....||..:|.....  :|::.|.|.|..|.
  Fly   446 RGLCMGWLNDHVYAIREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRN--KNYLHRMTCLFCLN 508

Yeast   544 TLVPVVSLDVVTEQLLPFISHLADDGVPNIRFNVAKSYAVIVKVLIKDEAKYDALIKNTILPSLQ 608
            .|..|...|:.|:.|||.:..||.|.|.|:||||||:...|...|  :.:..||.:|    |:|.
  Fly   509 VLAEVCGTDITTKLLLPTVLLLAADPVANVRFNVAKTLQKISPFL--EASVIDAQVK----PTLD 567

Yeast   609 TLCQDEDVDVKYFAKKSLA 627
            .|..|.|||||:||.:::|
  Fly   568 KLNTDTDVDVKHFAAQAIA 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPD3	NP_009386.1	HEAT repeat	39..63	CDD:293787	11/23 (48%)
		HEAT repeat	77..105	CDD:293787	18/27 (67%)
		HEAT repeat	115..145	CDD:293787	18/29 (62%)
		HEAT repeat	154..180	CDD:293787	13/25 (52%)
		HEAT repeat	191..220	CDD:293787	11/28 (39%)
		HEAT repeat	238..264	CDD:293787	11/25 (44%)
		HEAT repeat	282..306	CDD:293787	10/23 (43%)
		HEAT repeat	321..349	CDD:293787	13/27 (48%)
		HEAT repeat	360..390	CDD:293787	13/29 (45%)
		HEAT repeat	399..425	CDD:293787	14/25 (56%)
		HEAT repeat	436..465	CDD:293787	21/28 (75%)
		HEAT repeat	475..504	CDD:293787	17/28 (61%)
		HEAT repeat	514..545	CDD:293787	8/30 (27%)
		HEAT repeat	555..580	CDD:293787	14/24 (58%)
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	60/100 (60%)
		HEAT repeat	15..39	CDD:293787	11/23 (48%)
		HEAT repeat	53..80	CDD:293787	18/27 (67%)
		HEAT repeat	90..120	CDD:293787	18/29 (62%)
		HEAT repeat	129..154	CDD:293787	12/24 (50%)
		HEAT repeat	165..194	CDD:293787	11/28 (39%)
		HEAT_2	175..267	CDD:290374	35/100 (35%)
		HEAT_EZ	181..230	CDD:290247	19/54 (35%)
		HEAT repeat	206..232	CDD:293787	12/26 (46%)
		HEAT repeat	247..271	CDD:293787	10/23 (43%)
		HEAT repeat	285..313	CDD:293787	13/27 (48%)
		HEAT repeat	327..357	CDD:293787	13/29 (45%)
		HEAT repeat	366..392	CDD:293787	14/25 (56%)
		HEAT repeat	403..432	CDD:293787	21/28 (75%)
		HEAT repeat	444..470	CDD:293787	14/25 (56%)
		HEAT repeat	481..510	CDD:293787	8/30 (27%)
		HEAT repeat	520..546	CDD:293787	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346723
Domainoid	1	1.000	131	1.000	Domainoid score	I1129
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68559
Inparanoid	1	1.050	454	1.000	Inparanoid score	I247
Isobase	1	0.950	-	0	Normalized mean entropy	S459
OMA	1	1.010	-	-		QHG54034
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		oto100148
orthoMCL	1	0.900	-	-		OOG6_101100
Panther	1	1.100	-	-	LDO	PTHR10648
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1
SonicParanoid	1	1.000	-	-		X1096
TreeFam	1	0.960	-	-
	16	15.740