Protein Alignment DRS2 and CG33298

DIOPT Version :10

• Sequence 1: NP_009376.2
• Gene: DRS2 / 851207
• SGDID: S000000024
• Length: 1355
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1411
• Identity: 417/1411 - (29%)
• Similarity: 647/1411 - (45%)
• Gaps: 314/1411 - (22%)

Yeast    28 TTSHSGSRSKVTNSHANAN-----YIPPSHVLPEETIDLDADDDNIENDVHENLFMSNNHDDQTS 87
            |.|..||.:.....|:...     .:||.|          .::...|.....:......|..|.|
  Fly   137 TDSPPGSAAPAGRGHSRVGSKTDFILPPGH----------KEEPAREPSAPTSATGGRGHSRQAS 191

Yeast    88 WNANRFDSDAYQPQSLRAVKPPGLFARFGNGLKNAFTFKRKKGPESFEMNHYNAVTNNELDDNYL 152
            .:.:.:        :||..:.|..:.|        .|.......:.||...|..|..|.......
  Fly   192 RSESIY--------TLRRTEAPPWWKR--------LTLCNYNTGDKFEERSYRTVVPNHTVPPKT 240

Yeast   153 DSRNKFNIKILFNRYILRKNVGDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKF 217
            ..|:                    ..||:                :..|.|.||||...:|:||.
  Fly   241 PKRD--------------------HPNGQ----------------FVGNKIRTTKYTLLSFIPKN 269

Yeast   218 LFQEFSKYANLFFLCTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNS 282
            |.::|.:.|||:|:....:..||.:|...:...:..:|.||.|:|:|:..||.:|..|||.:||:
  Fly   270 LLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNT 334

Yeast   283 TAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKI 347
            |..::....:.:.:.:|.::|||||:.:.:.|.:|||.::|.:|:|:|:|||:|.:||||||||.
  Fly   335 TCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKR 399

Yeast   348 K---------QSRVETAKFIDVKTLKNMNGKVVSEQPNSSLYTYEGTMT-LNDRQIPLSPDQMIL 402
            :         ||....:||:         .:|.::.|.:.||.:.|.:. ....::|:|.:.::|
  Fly   400 REVVRGFEEMQSIFVPSKFV---------SRVEADAPTTKLYRFHGALIHPTGERVPISTECLLL 455

Yeast   403 RGATLRNTAWIFGLVIFTGHETKLLRNATATPIKRTAVEKIINRQIIALFTVLIVLILISSIGNV 467
            |.:.|:||.:|.|:|::.|||||.:.|.:....||:.||:.:|..:|....:|::|.::.:|| .
  Fly   456 RESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIG-C 519

Yeast   468 IMSTADAKHLSYLYLEGTNKAGLFFKDFLTFW---ILFSNLVPISLFVTVELIKYYQAFMIGSDL 529
            .|..:...|....||. .||.....:....||   ::...::|:||:||:||.|..|.|.|.:::
  Fly   520 RMWLSSFTHFPVPYLP-PNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNV 583

Yeast   530 DLYYEKTDTPTVVRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKSCSIAGHCY------IDK--- 585
            ||:..:|:..|..|..::.||||||::||:|||||||.|.|.|:.|.:.|..|      ::|
  Fly   584 DLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYS 648

Yeast   586 ---------IPEDK----TATVEDG----------------------IEVGYRKFDDL------- 608
                     ||.|.    .|.:..|                      :.||.....|:
  Fly   649 KPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGII 713

Yeast   609 -----------------KKKL--------------NDP--------------------------- 615
                             ::||              |.|
  Fly   714 EVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSP 778

Yeast   616 -----------------------------SDEDSP---------------------IINDFLTLL 630
                                         |:.:||                     :||..:|.:
  Fly   779 PPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSI 843

Yeast   631 ATC--------HTVIPEFQ-------SDGSIKYQAASPDEGALVQGGADLGYKFIIRKPNSVTVL 680
            ||.        ...:|..:       :||...|:|.||||.|||..........:.|.||.:.|.
  Fly   844 ATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVS 908

Yeast   681 LEETGEEKEYQLLNICEFNSTRKRMSAIFR-FPDGSIKLFCKGADTVILERLDDEANQYVEATMR 744
            :...|..:||::|.:..|:|:||.||.:.| .....|.|:.||||:.|:..|...::...|..:|
  Fly   909 MPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILR 973

Yeast   745 H-----LEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKNLILI 804
            .     |:.||.||||.|.:|.|.::..:|.:|.:.:.|...:|:||..:|.::...:|.||.|:
  Fly   974 EQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLL 1038

Yeast   805 GATAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLIINEETRDDT 869
            |||.|||:|||||||||.:|..|||.:||||||:.||||||..|.:|.::.|.|:.:...:||..
  Fly  1039 GATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAA 1103

Yeast   870 ERNLLEKINALN------EHQLSTHDMNTL-----------ALVIDGKSLGFALEPELEDYL--L 915
            |       .|:|      |:..:|   :||           |||:|||:|.|.|:|:.:..|  |
  Fly  1104 E-------TAINFYLTDMENDKTT---STLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFL 1158

Yeast   916 TVAKLCKAVICCRVSPLQKALVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAA 980
            .::|.|.:|:|||.:|||||.:||:||.:.:...||||||||||||||.|.|||||||.|||||.
  Fly  1159 RLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAV 1223

Yeast   981 RSADIAVGQFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVFANAFSGQSIMESWT 1045
            .:||..:.:|::|::|||.||.|.|.|:|..|||.||||.|.....|||.....||||.:|:...
  Fly  1224 MAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMY 1288

Yeast  1046 MSFYNLFFTVWPPFVIGVFDQFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFI 1110
            :..|||.||..||..|||:|:.|:..||.:.|.|||.|:.|..:..:.||..:::..:.|.::|.
  Fly  1289 LMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFF 1353

Yeast  1111 GTILIYR---YGFALNMHGELADHWSWGVTVYTTSVIIVLGKAALVTNQWTKFTLIAIPGSLLFW 1172
            ..:..|.   .|.           |.:|.|:..:.:...|...|:....||...:::|..||..:
  Fly  1354 VALCAYAESDVGI-----------WEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSF 1407

Yeast  1173 LIFFPIYASIFPHANISREYYGVVKHTYGSGVFWLTLIVLPIFALV 1218
            .:|..:|.|:..:....|..|.|:...:.|.|.||.:::..:.|::
  Fly  1408 YLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVL 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRS2	NP_009376.2	ATPase-Plipid	198..1240	CDD:273734	392/1236 (32%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	369/1123 (33%)