Protein Alignment NDST2 and sfl

DIOPT Version :10

• Sequence 1: NP_003626.1
• Gene: NDST2 / 8509
• HGNCID: 7681
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_001401031.1
• Gene: sfl / 38736
• FlyBaseID: FBgn0020251
• Length: 1129
• Species: Drosophila melanogaster
• Alignment Length: 896
• Identity: 485/896 - (54%)
• Similarity: 634/896 - (70%)
• Gaps: 37/896 - (4%)

Human     7 VVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSP----KAKEPLPLPLGDC---SSGGA---- 60
            :.|....:.:.|.:|.|:|.::.|:.:..:||.|..    ..::..|.|:.:|   :|||.
  Fly   161 IARRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINCRMINSGGKHIRN 225

Human    61 AGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMP 125
            |.|.|..        |.....|.:|.||||||:.||.||::|..:|..:|.:|..|:| |: .:|
  Fly   226 ASPAPDH--------RSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLP 280

Human   126 TLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLF 190
            .||:...|||.::::|||.||:|:|.|:|||||:||.||.|||:||....|.:|:.|||:.||||
  Fly   281 VLTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLF 345

Human   191 LHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGP 255
            :::||.|||..:||.:.:|.|||......|.||||||.:||.||||||||..|.....|  .|..
  Fly   346 VNTNLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQE--YPAD 408

Human   256 VLRRARLP--TVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDID 318
            .:.:.:||  ||:||.|..|||||||||..|.||||:|:|:||::||:..:|.|:|:|.||||||
  Fly   409 SVGQVQLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDID 473

Human   319 DIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEF 383
            |||||::|||::..||.||:.||..:..:||.|.||||||||:||.||.||:.|||.||::.:||
  Fly   474 DIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEF 538

Human   384 WWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKS 448
            .||.|||.|.||||:.|.::|..:|.||..||::|.||||.||:::||||||||.|..||.|||.
  Fly   539 NWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKK 603

Human   449 VWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGEL 513
            ||.::||||||||||||||.||||||..|||||||||||||||::.:.||||..:||.||:||||
  Fly   604 VWNVKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGEL 668

Human   514 FLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERS 578
            |.|::.|||:|||||:||||:|||.||||:|:::||||||.|:|.:.|||.||:.||.|.|:|..
  Fly   669 FQTIVYNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVD 733

Human   579 PLWQNPCDDKRHKDIWSKEKTCDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQ 643
            |:|.|||||.|||.||||.|.||.|||||::|||||||||::.|||:|.::.|:..||.||||:|
  Fly   734 PVWGNPCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQ 798

Human   644 FFNSPNYHKGIDWYMDFFPVPSNASTD-----------FLFEKSATYFDSEVVPRRGAALLPRAK 697
            |||..||::|:||||||||..|..:|.           |:|||||||||.|.||:|..||||.||
  Fly   799 FFNGNNYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAK 863

Human   698 IITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQR 762
            |:|:|.:||.||||||||||:|||.:|.||:|||||:||...|.||:.|:||||.||.|:.||:.
  Fly   864 IVTILISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEH 928

Human   763 WLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRC 827
            ||.|||:.||.|:||::||.||...|..:|:||.|.|.|:|:..||:|..|||:||.:...:.:|
  Fly   929 WLAYYPAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKC 993

Human   828 LGRSKGRRYPDMDTESRLFLTDFFRNHNLELSKLLSRLG-QPVPSWLREEL 877
            ||:||||:||.||..|...|..::.|||..|.|||.:|| :|:|.||:::|
  Fly   994 LGKSKGRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NDST2	NP_003626.1	Heparan sulfate N-deacetylase 2	41..597		312/568 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..81		10/38 (26%)
		HSNSD	83..514	CDD:463450	247/432 (57%)
		Heparan sulfate N-sulfotransferase 2	598..883		163/292 (56%)
		Sulfotransfer_1	603..852	CDD:425820	146/259 (56%)
sfl	NP_001401031.1	HSNSD	240..669	CDD:463450	247/432 (57%)
		Sulfotransfer_1	758..1017	CDD:425820	146/258 (57%)