Protein Alignment NDST2 and Hs3st-A

DIOPT Version :10

• Sequence 1: NP_003626.1
• Gene: NDST2 / 8509
• HGNCID: 7681
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_788409.1
• Gene: Hs3st-A / 37161
• FlyBaseID: FBgn0053147
• Length: 605
• Species: Drosophila melanogaster
• Alignment Length: 696
• Identity: 155/696 - (22%)
• Similarity: 235/696 - (33%)
• Gaps: 261/696 - (37%)

Human   340 TQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRSVL 404
            |..|.|....|.:.:...||.  ..|.|:......:.|:.:::        .|.||:.:
  Fly     2 TAAKRRASSSNSSGSSNTSGS--SNGNEQHSQQQHLQLQQQQQ--------QHAQPNEY------ 50

Human   405 ADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTS--TEEYPHLRPAR 467
                    |..|:|           |||.     :.|.|....:..|....|  |::| |.|..:
  Fly    51 --------QQLLQH-----------PHHH-----YQQHYSGNNNTSGNNSNSSNTQQY-HQRQQQ 90

Human   468 YRRGF------IHNGIMVLPRQT------------CGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
            ::...      :...|:.||:..            |.|..         |.||.     :...:|
  Fly    91 HQATLRDCSVKLPLDILWLPKSAMRPAGPDTSPTDCILVV---------GVSRP-----KLAVVF 141

Human   515 LTVLLNPISIFMT-HLSNYGNDRLGLYTFESLVRFLQC----WTRLRLQT--------------- 559
            |||:|  ||:|:| |:           .::|.|..:|.    ..|.||..
  Fly   142 LTVML--ISLFLTFHV-----------LYDSAVYNIQAAQAVHERHRLSMTASASALASSSSSSS 193

Human   560 ---------------LP----PVPLAQKYFE--LFPQERSPLWQNPCDDKRHKDIWSKEKTCDRL 603
                           ||    |||.:.:...  :||..|...                .||..||
  Fly   194 NSGSSFSSAGGASNHLPVFVKPVPSSNQLSHPMVFPSSRVHF----------------PKTSRRL 242

Human   604 PKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFN-SPNYHKGIDWYMDFFPVPSNA 667
            |:.||:|.:|.||.|:...|.|||.:..:      ..|:.||: ..||.||::||..  .:|.:.
  Fly   243 PQALIIGVRKCGTRALLEMLYLHPRIQKA------GGEVHFFDRDENYLKGLEWYRK--KMPHSF 299

Human   668 STDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHG----------DP 722
            ......|||.:||.|..||.|..|:....|::.::..|..||.|.|...|:|.          ||
  Fly   300 RGQITIEKSPSYFVSPEVPERVRAMNASIKLLLIVREPVTRAISDYTQLRSHAATAILPLAEKDP 364

Human   723 -------------------------------VALNYTFYQ-----------------------VI 733
                                           .:|.|...|                       .:
  Fly   365 PSPRESSGGGAGGGGAGGGGGSGTAAAKMPTQSLLYAKLQSARGYDNALLGGSGAGAKETKGKTV 429

Human   734 SAS---------------------------SQTPLALRSLQNRCLVP-------------GYYST 758
            |:|                           |...:|.:|.:...:.|             ..|..
  Fly   430 SSSLVRRQALGSGGGVAGAAMTTTTMSPMASAAQMAAKSFEELAIFPNGTVNEAYRPLSISMYHV 494

Human   759 HLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGG 823
            ||.|||..:|..|||:|:|..|..:|.:.::.|:.||||...:| :....|::.|||:|...:.|
  Fly   495 HLHRWLEVFPREQLLVVNGDRLIEDPVSQLKRIEAFLGIEHRVN-SEHFYFNETKGFYCLRYDNG 558

Human   824 KTRCLGRSKGRRYPDMDTESRLFLTDFFRNHNLELSKLLSR-LGQP 868
             .|||..:|||::|.:|......|..||..:|....:|:.. ||.|
  Fly   559 -DRCLRETKGRKHPHVDPVVVSRLRKFFAEYNQRFYELVGEDLGWP 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NDST2	NP_003626.1	Heparan sulfate N-deacetylase 2	41..597		58/317 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..81
		HSNSD	83..514	CDD:463450	34/193 (18%)
		Heparan sulfate N-sulfotransferase 2	598..883		97/377 (26%)
		Sulfotransfer_1	603..852	CDD:425820	88/353 (25%)
Hs3st-A	NP_788409.1	Sulfotransfer_1	242..587	CDD:473908	89/354 (25%)